BGC0000021: apoptolidin biosynthetic gene cluster from Nocardiopsis sp. FU 40
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Location: 1 - 115,746 nt. (total: 115,746 nt).
This entry is originally from NCBI GenBank JF819834.1.

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core biosynthetic genes
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Gene details
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000021
Short description apoptolidin biosynthetic gene cluster from Nocardiopsis sp. FU 40
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: JF819834.1
Compounds
  • apoptolidin
Species Nocardiopsis sp. FU 40 [taxonomy]
References
Chemical products information
apoptolidin
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C58H96O21
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEP40905.1
  • apoF
 1 - 1446 (+) carboxylic ester hydrolase
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  • AEP40906.1
  • apoH4
 1453 - 2460 (-) NDP-4-keto-6-deoxyhexose 4-ketoreductase
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  • AEP40907.1
  • apoGT3
 2821 - 4095 (+) glycosyl transferase
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  • AEP40908.1
  • apoH3
 4132 - 5124 (+) NDP-4-keto-6-deoxyhexose reductase
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  • AEP40909.1
  • apoM5
 5159 - 6433 (-) sugar 3-C-methyl transferase
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  • AEP40910.1
  • apoH2
 6430 - 7404 (-) putative dNDP-hexose 3-ketoreductase
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  • AEP40911.1
  • apoH1
 7401 - 8861 (-) NDP-hexose 2,3-dehydratase
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  • AEP40912.1
  • apoGT2
 9344 - 10513 (+) glycosyl transferases, related to UDP-glucuronosyltransferase
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  • AEP40913.1
  • apoD1
 10768 - 12027 (-) terminal dioxygenase large alpha-subunit
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  • AEP40914.1
  • apoD2
 12075 - 12671 (-) terminal dioxygenase small beta-subunit
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  • AEP40915.1
  • apoD3
 12689 - 13021 (-) dioxygenase ferredoxin subunit
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  • AEP40916.1
  • apoM4
 13035 - 14018 (-) rebeccamycin sugar 4'-O-methyltransferase
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  • AEP40917.1
  • apoS11
 14412 - 15200 (+) thioesterase
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  • AEP40918.1
  • apoR4
 15368 - 18496 (+) transcriptional regulator, SARP family
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  • AEP40919.1
  • apoM3
 18667 - 19452 (+) O-methyltransferase
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  • AEP40920.1
  • apoM2
 19605 - 20141 (+) caffeoyl-CoA o-methyltransferase
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  • AEP40921.1
  • apoE
 20381 - 21463 (-) haloacid dehalogenase-like hydrolases, methoxymalonyl-ACP biosynthesis
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  • AEP40922.1
  • apoI
 21460 - 22584 (-) acyl CoA dehydrogenase
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  • AEP40923.1
  • apoJ
 22577 - 22870 (-) acyl-carrier protein
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  • AEP40924.1
  • apoK
 22867 - 23733 (-) 3-hydroxyacyl-CoA dehydrogenase
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  • AEP40925.1
  • apoS10
 23922 - 28388 (-) polyketide synthase type I
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  • AEP40926.1
  • apoR3
 28684 - 29718 (-) operon transcriptional regulator
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  • AEP40927.1
  • apoR2
 30165 - 32288 (-) SARP transcriptional regulator
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  • AEP40928.1
  • apoC
 32781 - 33794 (-) NAD binding oxidoreductase
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  • AEP40929.1
  • apoB
 33833 - 35533 (-) glucose-methanol-choline oxidoreductase
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  • AEP40930.1
  • apoG
 35620 - 36162 (+) polyketide cyclase
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  • AEP40931.1
  • apoP
 36375 - 37568 (-) cytochrome P450 monooxygenase
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  • AEP40932.1
  • apoS8
 37599 - 43232 (-) polyketide synthase type I
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  • AEP40933.1
  • apoGT1
 43843 - 44973 (-) UDP-glucosyl transferase
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  • AEP40934.1
  • apoS7
 45012 - 55520 (-) polyketide synthase type I
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  • AEP40935.1
  • apoS6
 55537 - 65484 (-) polyketide synthase type I
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  • AEP40936.1
  • apoS5
 65477 - 81277 (-) polyketide synthase type I
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  • AEP40937.1
  • apoS4
 81326 - 84694 (-) polyketide synthase type I
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  • AEP40938.1
  • apoS3
 84753 - 86120 (-) polyketide synthase type I
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  • AEP40939.1
  • apoS2
 86172 - 91535 (-) polyketide synthase type I
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  • AEP40940.1
  • apoS1
 91574 - 110368 (-) polyketide synthase type I
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  • AEP40941.1
  • apoM1
 110681 - 111472 (+) sugar O-methyltransferase
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  • AEP40942.1
  • apoA
 111950 - 113080 (+) unknown
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  • AEP40943.1
  • apoR1
 112897 - 115746 (-) SARP transcriptional regulator
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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