BGC0000021: apoptolidin biosynthetic gene cluster from Nocardiopsis sp. FU 40
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Location: 1 - 115,746 nt. (total: 115,746 nt).
This entry is originally from NCBI GenBank JF819834.1.

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General
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Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000021
Short description apoptolidin biosynthetic gene cluster from Nocardiopsis sp. FU 40
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
JF819834.1
via
Compounds
  • apoptolidin
Species Nocardiopsis sp. FU 40 [taxonomy]
References
Chemical products information
apoptolidin Evidence:
Copy SMILES
C58H96O21
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEP40905.1
  • apoF
 1 - 1446 (+) carboxylic ester hydrolase
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    • AEP40906.1
    • apoH4
    		 1453 - 2460 (-) NDP-4-keto-6-deoxyhexose 4-ketoreductase
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      • AEP40907.1
      • apoGT3
      		 2821 - 4095 (+) glycosyl transferase
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        • AEP40908.1
        • apoH3
        		 4132 - 5124 (+) NDP-4-keto-6-deoxyhexose reductase
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          • AEP40909.1
          • apoM5
          		 5159 - 6433 (-) sugar 3-C-methyl transferase
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            • AEP40910.1
            • apoH2
            		 6430 - 7404 (-) putative dNDP-hexose 3-ketoreductase
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              • AEP40911.1
              • apoH1
              		 7401 - 8861 (-) NDP-hexose 2,3-dehydratase
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                • AEP40912.1
                • apoGT2
                		 9344 - 10513 (+) glycosyl transferases, related to UDP-glucuronosyltransferase
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                  • AEP40913.1
                  • apoD1
                  		 10768 - 12027 (-) terminal dioxygenase large alpha-subunit
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                    • AEP40914.1
                    • apoD2
                    		 12075 - 12671 (-) terminal dioxygenase small beta-subunit
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                      • AEP40915.1
                      • apoD3
                      		 12689 - 13021 (-) dioxygenase ferredoxin subunit
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                        • AEP40916.1
                        • apoM4
                        		 13035 - 14018 (-) rebeccamycin sugar 4'-O-methyltransferase
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                          • AEP40917.1
                          • apoS11
                          		 14412 - 15200 (+) thioesterase
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                            • AEP40918.1
                            • apoR4
                            		 15368 - 18496 (+) transcriptional regulator, SARP family
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                              • AEP40919.1
                              • apoM3
                              		 18667 - 19452 (+) O-methyltransferase
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                                • AEP40920.1
                                • apoM2
                                		 19605 - 20141 (+) caffeoyl-CoA o-methyltransferase
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                                  • AEP40921.1
                                  • apoE
                                  		 20381 - 21463 (-) haloacid dehalogenase-like hydrolases, methoxymalonyl-ACP biosynthesis
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                                    • AEP40922.1
                                    • apoI
                                    		 21460 - 22584 (-) acyl CoA dehydrogenase
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                                      • AEP40923.1
                                      • apoJ
                                      		 22577 - 22870 (-) acyl-carrier protein
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                                        • AEP40924.1
                                        • apoK
                                        		 22867 - 23733 (-) 3-hydroxyacyl-CoA dehydrogenase
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                                          • AEP40925.1
                                          • apoS10
                                          		 23922 - 28388 (-) polyketide synthase type I
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                                            • AEP40926.1
                                            • apoR3
                                            		 28684 - 29718 (-) operon transcriptional regulator
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                                              • AEP40927.1
                                              • apoR2
                                              		 30165 - 32288 (-) SARP transcriptional regulator
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                                                • AEP40928.1
                                                • apoC
                                                		 32781 - 33794 (-) NAD binding oxidoreductase
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                                                  • AEP40929.1
                                                  • apoB
                                                  		 33833 - 35533 (-) glucose-methanol-choline oxidoreductase
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                                                    • AEP40930.1
                                                    • apoG
                                                    		 35620 - 36162 (+) polyketide cyclase
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                                                      • AEP40931.1
                                                      • apoP
                                                      		 36375 - 37568 (-) cytochrome P450 monooxygenase
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                                                        • AEP40932.1
                                                        • apoS8
                                                        		 37599 - 43232 (-) polyketide synthase type I
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                                                          • AEP40933.1
                                                          • apoGT1
                                                          		 43843 - 44973 (-) UDP-glucosyl transferase
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                                                            • AEP40934.1
                                                            • apoS7
                                                            		 45012 - 55520 (-) polyketide synthase type I
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                                                              • AEP40935.1
                                                              • apoS6
                                                              		 55537 - 65484 (-) polyketide synthase type I
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                                                                • AEP40936.1
                                                                • apoS5
                                                                		 65477 - 81277 (-) polyketide synthase type I
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                                                                  • AEP40937.1
                                                                  • apoS4
                                                                  		 81326 - 84694 (-) polyketide synthase type I
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                                                                    • AEP40938.1
                                                                    • apoS3
                                                                    		 84753 - 86120 (-) polyketide synthase type I
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                                                                      • AEP40939.1
                                                                      • apoS2
                                                                      		 86172 - 91535 (-) polyketide synthase type I
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                                                                        • AEP40940.1
                                                                        • apoS1
                                                                        		 91574 - 110368 (-) polyketide synthase type I
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                                                                          • AEP40941.1
                                                                          • apoM1
                                                                          		 110681 - 111472 (+) sugar O-methyltransferase
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                                                                            • AEP40942.1
                                                                            • apoA
                                                                            		 111950 - 113080 (+) unknown
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                                                                              • AEP40943.1
                                                                              • apoR1
                                                                              		 112897 - 115746 (-) SARP transcriptional regulator
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                                                                                Biosynthesis information

                                                                                No biosynthesis information available for this record.

                                                                                Annotation changelog

                                                                                Entry version: 4

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2022-10-07
                                                                                Update chemical activity to schema version 2.11
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 3

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2022-09-15
                                                                                Updated bioactivity data
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 2

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2019-10-16
                                                                                Migrated from v1.4
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                2019-10-16
                                                                                Updated compound(s) information (NPAtlas curation)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                Entry version: 1

                                                                                Date
                                                                                Changes
                                                                                Submitters
                                                                                Reviewers
                                                                                2015-06-12
                                                                                Submitted
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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