BGC0000022 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000022 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	41,240	asperfuranone	PKS	100%

BGC0000022 - Region 1 - T1PKS

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Location: 1 - 41,240 nt. (total: 41,240 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,241
Label		BGC0000022

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022	1.00	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0002267	0.46	Polyketide	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0000099	0.37	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002404	0.34	Other	falcarindiol	Solanum lycopersicum
BGC0002155	0.33	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002429	0.32	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002191	0.32	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.32	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002194	0.31	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001252	0.30	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022	1.00	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0002267	0.76	Polyketide	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0000099	0.69	Polyketide	monascorubrin	Talaromyces marneffei
BGC0002404	0.67	Other	falcarindiol	Solanum lycopersicum
BGC0002155	0.66	Polyketide	nectriapyrone C, nectriapyrone D, nectriapyrone	Pyricularia oryzae 70-15
BGC0002429	0.65	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001606	0.65	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289
BGC0002194	0.64	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001252	0.64	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 41240:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: AN1036.2 + AN1034.2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AN1034.2

PKS_AT (975..1277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 51.4
Methoxymalonyl-CoA: 50.0
Methylmalonyl-CoA: 49.1
Ethylmalonyl-CoA: 38.6
inactive: 34.3
CHC-CoA: 28.4
Benzoyl-CoA: 22.1
2-Methylbutyryl-CoA: 19.7
trans-1,2-CPDA: 18.7
fatty_acid: 18.7
Propionyl-CoA: 18.2
Isobutyryl-CoA: 16.2
Acetyl-CoA: 14.4
3-Methylbutyryl-CoA: 0.0

AN1036.2

PKS_AT (533..876): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 61.6
Malonyl-CoA: 61.6
Methoxymalonyl-CoA: 61.5
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 29.3
Propionyl-CoA: 25.6
Benzoyl-CoA: 21.9
trans-1,2-CPDA: 14.9
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 2.3
inactive: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
Acetyl-CoA: -0.8