BGC0000022 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000022 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	60,868	High	asperfuranone	PKS

BGC0000022 - Region 1 - T1PKS

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Location: 1 - 60,868 nt. (total: 60,868 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 60,869
Label		BGC0000022

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

AN1030.2: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

AN1035.2: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Ligases: synthase

AN1034.2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AN1036.2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022.3	0.99	PKS	asperfuranone	Aspergillus nidulans FGSC A4
BGC0002267.2	0.76	PKS	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022.3	0.99	PKS	asperfuranone	Aspergillus nidulans FGSC A4
BGC0002267.2	0.76	PKS	azasperpyranone A, azasperpyranone B, azasperpyranone C, azasperpyranone D, azasperpyranone E, azasperpyranone F, azasperpyranone G, azasperpyranone H	Aspergillus terreus NIH2624
BGC0002191.2	0.75	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.65	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 60868:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: AN1036.2 + AN1034.2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AN1034.2: mal

PKS_AT (975..1277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 51.4
Methoxymalonyl-CoA: 50.0
Methylmalonyl-CoA: 49.1
Ethylmalonyl-CoA: 38.6
inactive: 34.3
CHC-CoA: 28.4
Benzoyl-CoA: 22.1
2-Methylbutyryl-CoA: 19.7
trans-1,2-CPDA: 18.7
fatty_acid: 18.7
Propionyl-CoA: 18.2
Isobutyryl-CoA: 16.2
Acetyl-CoA: 14.4
3-Methylbutyryl-CoA: 0.0

AN1036.2: pk

PKS_AT (533..876): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 61.6
Malonyl-CoA: 61.6
Methoxymalonyl-CoA: 61.5
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 29.3
Propionyl-CoA: 25.6
Benzoyl-CoA: 21.9
trans-1,2-CPDA: 14.9
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 2.3
inactive: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
Acetyl-CoA: -0.8

Link to PARAS substrate predictor