BGC0000023: aurafuron A biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
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Location: 1 - 58,500 nt. (total: 58,500 nt).
This entry is originally from NCBI GenBank AM850130.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000023
Short description aurafuron A biosynthetic gene cluster from Stigmatella aurantiaca DW4/3-1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AM850130.1
Compounds
  • aurafuron A
Species Stigmatella aurantiaca DW4/3-1 [taxonomy]
References
Chemical products information
aurafuron A
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C22H34O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAO98841.1
 1 - 1350 (+) hypothetical protein
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  • CAO98842.1
 1384 - 2424 (-) hypothetical protein
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  • CAO98843.1
 2541 - 4415 (-) hypothetical protein
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  • CAO98844.1
 4952 - 5443 (+) hypothetical protein
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  • CAO98845.1
  • aufA
 5683 - 7113 (+) cytochrome P450 monooxygenase AufA
  • Tailoring (Oxidation)
Sequence-based prediction
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  • CAO98846.1
  • aufB
 7260 - 8498 (+) cytochrome P450 monooxygenase AufB
  • Tailoring (Oxidation)
Sequence-based prediction
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  • CAO98847.1
  • aufC
 8559 - 14162 (-) polyketide synthase AufC
  • Scaffold biosynthesis
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  • CAO98879.1
  • aufD
 14167 - 24348 (-) polyketide synthase AufD
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAO98848.1
  • aufE
 24944 - 30439 (+) polyketide synthase AufE
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAO98849.1
  • aufF
 30506 - 40588 (+) polyketide synthase AufF
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAO98850.1
  • aufG
 40595 - 47005 (+) polyketide synthase AufG
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAO98851.1
  • aufH
 46998 - 48407 (+) cytochrome P450 monooxygenase AufH
  • Tailoring (Oxidation)
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  • CAO98852.1
  • aufI
 48404 - 56530 (+) polyketide synthase AufI
  • Scaffold biosynthesis
Sequence-based prediction
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  • CAO98853.1
  • aufJ
 56535 - 58055 (+) monooxygenase AufJ
  • Tailoring (Oxidation)
Sequence-based prediction
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Polyketide-specific information
Subclass Other
Starter unit 3-Methylbutyryl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
aufC
+
aufE
+
aufG
+
aufI
+
aufD
+
aufF 		Synthase subclass: Modular type I
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: aufI
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 2
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: aufD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: aufD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: aufF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
Module 5
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: aufF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: aufC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: aufE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: aufG
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 7SR74ARK6JXRBGJRGO2LUHE7, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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