Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000023.1:
Cluster 1Polyketide158500

BGC0000023, aurafuron biosynthetic gene cluster from Stigmatella aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Aurafuron A
SMILES string: Copy to clipboard
Molecular formula: C22H34O5
Exact molecular mass: 379.2479 Da ([M+H]+)
Molecular activity: Antifungal, Cytotoxic
Molecular target: cholesterol biosynthesis

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
3-Methylbutyryl-CoA
Thioesterase type:
None
Release / cyclization type:
Other

Modular polyketide synthases:
aufC (CAO98847.1)
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

aufD (CAO98879.1)
Module 2
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Module is iterated
Evidence for iteration: Unknown

aufE (CAO98848.1)
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group

aufF (CAO98849.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Module is iterated
Evidence for iteration: Unknown
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: A-group

aufG (CAO98850.1)
Module 8
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction

aufI (CAO98852.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: B-group

Gene cluster description

aurafuron (BGC0000023). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AM850130, positions 1-58500. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:No
Contact for this cluster:Daniel Krug (HIPS)

Literature references

1. Frank B et al. (2007) From genetic diversity to metabolic unity: studies on the biosynthesis of aurafurones and aurafuron-like structures in myxobacteria and streptomycetes. J Mol Biol 374(1):24-38. doi: 10.1016/j.jmb.2007.09.015. Epub 2007