BGC0000029: BE-14106 biosynthetic gene cluster from Streptomyces sp. DSM 21069
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Location: 1 - 85,059 nt. (total: 85,059 nt).
This entry is originally from NCBI GenBank FJ872523.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000029
Short description BE-14106 biosynthetic gene cluster from Streptomyces sp. DSM 21069
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: FJ872523.1
Compounds
  • BE-14106
Species Streptomyces sp. DSM 21069 [taxonomy]
References
Chemical products information
BE-14106
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C27H37N1O3
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACO94452.1
 133 - 540 (-) putative secreted metal-binding protein
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  • ACO94453.1
 579 - 1178 (-) putative lipoprotein
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  • ACO94454.1
 1363 - 1797 (-) hypothetical protein
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  • ACO94455.1
  • becH
 3578 - 6433 (+) LuxR-type transcriptional regulator
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  • ACO94456.1
  • becA
 6784 - 23532 (+) polyketide synthase type I
  • Precursor biosynthesis
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  • ACO94457.1
  • becI
 23864 - 24952 (-) glycine oxidase/FAD-dependent oxidoreductase
  • Precursor biosynthesis
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  • ACO94458.1
  • becC
 24949 - 27033 (-) polyketide synthase type I
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  • ACO94459.1
  • becU
 27065 - 27628 (-) putative NRPS accessory protein
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  • ACO94460.1
  • becB
 27625 - 38208 (-) polyketide synthase type I
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  • ACO94461.1
  • becJ
 38274 - 39872 (-) putative AMP-dependent acyl-CoA synthetase/ligase
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  • ACO94462.1
  • becK
 40067 - 41038 (+) acyltransferase
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  • ACO94463.1
  • becS
 41054 - 41290 (-) peptidyl carrier protein
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  • ACO94464.1
  • becL
 41408 - 42925 (+) NRPS adenylation domain protein
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  • ACO94465.1
  • becM
 42908 - 43504 (-) TetR-type transcriptional regulator
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  • ACO94466.1
  • becN
 43606 - 45180 (+) MFS-type efflux pump
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  • ACO94467.1
  • becO
 45273 - 46508 (-) P450 monooxygenase
  • Tailoring (Monooxygenation)
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  • ACO94468.1
  • becD
 46555 - 56673 (-) polyketide synthase type I
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  • ACO94469.1
  • becP
 56681 - 57622 (-) putative L-amino acid amidase/proline iminopeptidase
  • Scaffold biosynthesis
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  • ACO94470.1
  • becG
 57725 - 63685 (-) polyketide synthase type I
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  • ACO94471.1
  • becF
 63693 - 73826 (-) polyketide synthase type I
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  • ACO94472.1
  • becE
 73874 - 78769 (-) polyketide synthase type I
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  • ACO94473.1
  • becT
 79074 - 79361 (-) SimX2-like protein
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  • ACO94474.1
  • becQ
 79683 - 80456 (+) thioesterase type II
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  • ACO94475.1
 80609 - 81322 (+) PlsC-type phospholipid/glycerol acyltransferase
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  • ACO94476.1
 81419 - 83032 (-) putative tripeptidylaminopeptidase
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  • ACO94477.1
 83178 - 83948 (-) putative urease accessory protein
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  • ACO94478.1
 83945 - 84640 (-) putative urease accessory protein
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  • ACO94479.1
 84682 - >85059 (-) putative urease accessory protein
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Polyketide-specific information
Subclass Other
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
becE
+
becB
+
becD
+
becA
+
becG
+
becF 		Synthase subclass: Modular type I
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becA
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becA
Core domains: Ketosynthase, Acyltransferase, Dehydratase
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becB
Core domains: Thiolation (ACP/PCP), Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becD
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becD
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becE
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: becG
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: MU4LZLKCEF7Q67JF6ZEMKX3R, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Removed duplicate gene name
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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