BGC0000029: BE-14106 biosynthetic gene cluster from Streptomyces sp. DSM 21069
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Location: 1 - 85,059 nt. (total: 85,059 nt).
This entry is originally from NCBI GenBank FJ872523.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000029
Short description BE-14106 biosynthetic gene cluster from Streptomyces sp. DSM 21069
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
FJ872523.1
via Knock-out studies, Enzymatic assays
Compounds
  • BE-14106
Species Streptomyces sp. DSM 21069 [taxonomy]
References
Chemical products information
BE-14106 Evidence:
Copy SMILES
C27H37N1O3
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACO94452.1
 133 - 540 (-) putative secreted metal-binding protein
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    • ACO94453.1
    		 579 - 1178 (-) putative lipoprotein
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      • ACO94454.1
      		 1363 - 1797 (-) hypothetical protein
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        • ACO94455.1
        • becH
        		 3578 - 6433 (+) LuxR-type transcriptional regulator
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          • ACO94456.1
          • becA
          		 6784 - 23532 (+) polyketide synthase type I
          • Precursor biosynthesis
          • Knock-out
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          • ACO94457.1
          • becI
          		 23864 - 24952 (-) glycine oxidase/FAD-dependent oxidoreductase
          • Precursor biosynthesis
          • Activity assay
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          • ACO94458.1
          • becC
          		 24949 - 27033 (-) polyketide synthase type I
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            • ACO94459.1
            • becU
            		 27065 - 27628 (-) putative NRPS accessory protein
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              • ACO94460.1
              • becB
              		 27625 - 38208 (-) polyketide synthase type I
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                • ACO94461.1
                • becJ
                		 38274 - 39872 (-) putative AMP-dependent acyl-CoA synthetase/ligase
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                  • ACO94462.1
                  • becK
                  		 40067 - 41038 (+) acyltransferase
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                    • ACO94463.1
                    • becS
                    		 41054 - 41290 (-) peptidyl carrier protein
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                      • ACO94464.1
                      • becL
                      		 41408 - 42925 (+) NRPS adenylation domain protein
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                        • ACO94465.1
                        • becM
                        		 42908 - 43504 (-) TetR-type transcriptional regulator
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                          • ACO94466.1
                          • becN
                          		 43606 - 45180 (+) MFS-type efflux pump
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                            • ACO94467.1
                            • becO
                            		 45273 - 46508 (-) P450 monooxygenase
                            • Tailoring
                            • Knock-out
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                            • ACO94468.1
                            • becD
                            		 46555 - 56673 (-) polyketide synthase type I
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                              • ACO94469.1
                              • becP
                              		 56681 - 57622 (-) putative L-amino acid amidase/proline iminopeptidase
                              • Scaffold biosynthesis
                              • Activity assay
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                              • ACO94470.1
                              • becG
                              		 57725 - 63685 (-) polyketide synthase type I
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                                • ACO94471.1
                                • becF
                                		 63693 - 73826 (-) polyketide synthase type I
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                                  • ACO94472.1
                                  • becE
                                  		 73874 - 78769 (-) polyketide synthase type I
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                                    • ACO94473.1
                                    • becT
                                    		 79074 - 79361 (-) SimX2-like protein
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                                      • ACO94474.1
                                      • becQ
                                      		 79683 - 80456 (+) thioesterase type II
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                                        • ACO94475.1
                                        		 80609 - 81322 (+) PlsC-type phospholipid/glycerol acyltransferase
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                                          • ACO94476.1
                                          		 81419 - 83032 (-) putative tripeptidylaminopeptidase
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                                            • ACO94477.1
                                            		 83178 - 83948 (-) putative urease accessory protein
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                                              • ACO94478.1
                                              		 83945 - 84640 (-) putative urease accessory protein
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                                                • ACO94479.1
                                                		 84682 - >85059 (-) putative urease accessory protein
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                                                  Biosynthesis information

                                                  Biosynthetic modules

                                                  Name
                                                  1
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becA
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, carrier (ACP)
                                                  Name
                                                  2
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becA
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  3
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becA
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  4
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becA
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase
                                                  Name
                                                  5
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becB
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP), carrier (ACP)
                                                  Name
                                                  6
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becB
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  7
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becD
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  8
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becD
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  9
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becE
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  10
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becF
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  11
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becF
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                                                  Name
                                                  12
                                                  Type
                                                  pks-modular
                                                  Genes
                                                  becG
                                                  Substrates
                                                  Integrated Monomers
                                                  Domains
                                                  acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, thioesterase, carrier (ACP)
                                                  Annotation changelog

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Removed gene names of 'No gene ID'
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Removed duplicate gene name
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Sorted modules by module number
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  2019-10-16
                                                  Updated compound(s) information (NPAtlas curation)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: MU4LZLKCEF7Q67JF6ZEMKX3R)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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