Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000029.1:
Cluster 1Polyketide185059

BGC0000029, BE-14106 biosynthetic gene cluster from Streptomyces sp. DSM. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: BE-14106
PubChem ID: 6439426
SMILES string: Copy to clipboard
Molecular formula: C27H37NO3
Average molecular mass: 423.597 Da
Molecular activity: Cytotoxic
Molecular target: unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Other
Thioesterase type:
Type I
Release / cyclization type:
Macrolactamization

Modular polyketide synthases:
becE (ACO94472.1)
Module 9
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

becF (ACO94471.1)
Module 10
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 11
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

becG (ACO94470.1)
Module 12
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

becD (ACO94468.1)
Module 7
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 8
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

becB (ACO94460.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None

becA (ACO94456.1)
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None
Module is non-elongating
Evidence for non-elongation: Unknown
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None

Gene cluster description

BE-14106 (BGC0000029). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank FJ872523. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays
MIxS-compliance:Unknown
Contact for this cluster:Sergey Zotchev (Norwegian University of Science and Technology)

Literature references

1. Jorgensen H et al. (2009) Biosynthesis of macrolactam BE-14106 involves two distinct PKS systems and amino acid processing enzymes for generation of the aminoacyl starter unit. Chem Biol 16(10):1109-21. doi: 10.1016/j.chembiol.2009.09.014.