BGC0000031 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000031 (Streptomyces parvulus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	74,787	borrelidin	PKS:Type I	100%

BGC0000031 - Region 1 - T1PKS

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Location: 1 - 74,787 nt. (total: 74,787 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 74,788
Label		BGC0000031

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000031	0.95	Polyketide	borrelidin	Streptomyces parvulus
BGC0001533	0.87	Polyketide	borrelidin	Streptomyces rochei
BGC0000016	0.39	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.33	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002266	0.32	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002404	0.32	Other	falcarindiol	Solanum lycopersicum
BGC0002211	0.31	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002729	0.31	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002228	0.31	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0000018	0.31	Polyketide	angolamycin	Streptomyces eurythermus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000031	1.00	Polyketide	borrelidin	Streptomyces parvulus
BGC0001533	0.96	Polyketide	borrelidin	Streptomyces rochei
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.66	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002266	0.65	Terpene, Polyketide	calidoustene A, calidoustene B, calidoustene C	Aspergillus calidoustus
BGC0002404	0.65	Other	falcarindiol	Solanum lycopersicum
BGC0002211	0.65	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0002729	0.65	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002228	0.65	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0000018	0.64	Polyketide	angolamycin	Streptomyces eurythermus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 70742:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ccmal - Me-ccmal) + (Me-ohmal) + (Me-redmal) + (ohmal)
Non-colinear ordering:: borA1 + borA2 + borA3 + borA4 + borA5 + borA6

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

borA1

PKS_AT (323..622): pk

ATSignature: trans-1,2-CPDA

Top 3 matches:: trans-1,2-CPDA: 100.0%; Ethylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 290.9
Ethylmalonyl-CoA: 173.8
Methylmalonyl-CoA: 166.7
Methoxymalonyl-CoA: 150.6
2-Methylbutyryl-CoA: 116.2
Propionyl-CoA: 103.8
CHC-CoA: 91.7
Malonyl-CoA: 65.2
Acetyl-CoA: 56.6
Benzoyl-CoA: 54.1
Isobutyryl-CoA: 52.5
fatty_acid: 31.6
3-Methylbutyryl-CoA: 30.1
inactive: 14.2

borA2

PKS_AT (558..844): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.9
inactive: 95.6
Methoxymalonyl-CoA: 56.6
Propionyl-CoA: 38.1
Methylmalonyl-CoA: 37.7
Isobutyryl-CoA: 18.7
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.2
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

borA3

PKS_AT (560..846): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.3
inactive: 95.6
Methoxymalonyl-CoA: 57.2
Propionyl-CoA: 39.0
Methylmalonyl-CoA: 38.8
Isobutyryl-CoA: 19.3
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.4
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2246..2535): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

borA4

PKS_AT (543..832): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.6
Ethylmalonyl-CoA: 184.3
Methoxymalonyl-CoA: 160.9
2-Methylbutyryl-CoA: 128.6
Propionyl-CoA: 111.1
trans-1,2-CPDA: 109.9
CHC-CoA: 98.7
Malonyl-CoA: 94.2
Isobutyryl-CoA: 69.4
Benzoyl-CoA: 68.0
Acetyl-CoA: 56.0
3-Methylbutyryl-CoA: 43.0
inactive: 35.2
fatty_acid: 28.9

borA5

PKS_AT (580..874): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.0
Ethylmalonyl-CoA: 188.6
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 135.7
trans-1,2-CPDA: 120.1
Propionyl-CoA: 115.7
Malonyl-CoA: 101.9
CHC-CoA: 100.8
Isobutyryl-CoA: 76.6
Benzoyl-CoA: 73.1
Acetyl-CoA: 55.9
3-Methylbutyryl-CoA: 53.7
inactive: 38.8
fatty_acid: 31.5

borA6

PKS_AT (556..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.3
inactive: 95.6
Methoxymalonyl-CoA: 57.2
Propionyl-CoA: 39.0
Methylmalonyl-CoA: 38.8
Isobutyryl-CoA: 19.3
fatty_acid: 14.4
Ethylmalonyl-CoA: 14.2
Acetyl-CoA: 10.8
Benzoyl-CoA: 7.3
trans-1,2-CPDA: 6.4
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0