BGC0000031: borrelidin biosynthetic gene cluster from Streptomyces parvulus
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Location: 1 - 74,787 nt. (total: 74,787 nt).
This entry is originally from NCBI GenBank AJ580915.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000031
Short description borrelidin biosynthetic gene cluster from Streptomyces parvulus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AJ580915.1
via Knock-out studies
Compounds
  • borrelidin
Species Streptomyces parvulus [taxonomy]
References
Chemical products information
borrelidin Evidence:
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C28H43N1O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE45653.1
 2 - 313 (+) hypothetical protein
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    • CAE45654.1
    		 501 - 3107 (+) hypothetical protein
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      • CAE45655.1
      		 3172 - 3810 (-) hypothetical protein
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        • CAE45656.1
        		 3935 - 4924 (-) hypothetical protein
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          • CAE45657.1
          		 5123 - 5953 (+) hypothetical protein
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            • CAE45658.1
            		 5961 - 6518 (-) hypothetical protein
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              • CAE45659.1
              		 6567 - 7538 (+) hypothetical protein
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                • CAE45660.1
                • borB
                		 7603 - 8397 (-) thioesterase type II
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                  • CAE45661.1
                  • borC
                  		 8397 - 9194 (-) putative ketoreductase
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                    • CAE45662.1
                    • borD
                    		 9244 - 9996 (-) putative ketoreductase
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                      • CAE45663.1
                      • borE
                      		 9993 - 11165 (-) putative muconate cyclo-isomerase/lactamase
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                        • CAE45664.1
                        • borF
                        		 11162 - 11980 (-) hypothetical protein
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                          • CAE45665.1
                          • borG
                          		 11992 - 13611 (-) putative acetolactate synthase
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                            • CAE45666.1
                            • borH
                            		 13608 - 15659 (-) putative dehydratase
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                              • CAE45667.1
                              • borA1
                              		 16184 - 18814 (+) borrelidin polyketide synthase, type I
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                                • CAE45668.1
                                • borA2
                                		 18875 - 23590 (+) borrelidin polyketide synthase, type I
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                                  • CAE45669.1
                                  • borA3
                                  		 23686 - 34188 (+) borrelidin polyketide synthase, type I
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                                    • CAE45670.1
                                    • borA4
                                    		 34224 - 39047 (+) borrelidin polyketide synthase, type I
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                                      • CAE45671.1
                                      • borA5
                                      		 39044 - 45514 (+) borrelidin polyketide synthase, type I
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                                        • CAE45672.1
                                        • borA6
                                        		 45514 - 50742 (+) Borrelidin polyketide synthase, type I
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                                          • CAE45673.1
                                          • borI
                                          		 50739 - 52019 (+) putative cytochrome P450
                                          • Tailoring
                                          • Knock-out
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                                          • CAE45674.1
                                          • borJ
                                          		 52113 - 53477 (+) putative aminotransferase
                                          • Tailoring
                                          • Knock-out
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                                          • CAE45675.1
                                          • borK
                                          		 53474 - 54466 (+) putative oxidoreductase
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                                            • CAE45676.1
                                            • borL
                                            		 54506 - 56176 (+) hypothetical protein
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                                              • CAE45677.1
                                              • borM
                                              		 56181 - 57098 (+) putative dehydrogenase
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                                                • CAE45678.1
                                                • borN
                                                		 57112 - 57858 (+) putative 2-hydroxyhept-2,4-diene-1,7-dioate isomerase
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                                                  • CAE45679.1
                                                  • borO
                                                  		 57939 - 59966 (+) Threonyl-tRNA synthetase
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                                                    • CAE45680.1
                                                    		 60153 - 60533 (-) hypothetical protein
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                                                      • CAE45681.1
                                                      		 60620 - 61003 (+) hypothetical protein
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                                                        • CAE45682.1
                                                        		 61188 - 61436 (+) hypothetical protein
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                                                          • CAE45683.1
                                                          		 61526 - 61738 (+) hypothetical protein
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                                                            • CAE45684.1
                                                            		 61767 - 62285 (-) hypothetical protein
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                                                              • CAE45685.1
                                                              		 62586 - >62885 (-) hypothetical protein
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                                                                • CAE45686.1
                                                                		 62885 - 63076 (-) hypothetical protein
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                                                                  • CAE45687.1
                                                                  		 63155 - 65071 (-) hypothetical protein
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                                                                    • CAE45688.1
                                                                    		 65374 - 65871 (+) hypothetical protein
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                                                                      • CAE45689.1
                                                                      		 65942 - 68293 (-) hypothetical protein
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                                                                        • CAE45690.1
                                                                        		 68290 - 68823 (-) hypothetical protein
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                                                                          • CAE45691.1
                                                                          		 69681 - 70436 (+) hypothetical protein
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                                                                            • CAE45692.1
                                                                            		 70445 - 71848 (+) hypothetical protein
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                                                                              • CAE45693.1
                                                                              		 71845 - 72957 (+) hypothetical protein
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                                                                                • CAE45694.1
                                                                                		 73037 - 73942 (+) hypothetical protein
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                                                                                  • CAE45695.1
                                                                                  		 73995 - 74537 (-) hypothetical protein
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                                                                                    Biosynthesis information

                                                                                    Biosynthetic modules

                                                                                    Name
                                                                                    A0
                                                                                    Type
                                                                                    pks-modular-starter
                                                                                    Genes
                                                                                    borA1
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, carrier (ACP)
                                                                                    Name
                                                                                    1
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA2
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                    Name
                                                                                    2
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA3
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                    Name
                                                                                    3
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA3
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, carrier (ACP)
                                                                                    Name
                                                                                    4
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA4
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                    Name
                                                                                    5
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA5
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, dehydratase, enoylreductase, carrier (ACP)
                                                                                    Name
                                                                                    6
                                                                                    Type
                                                                                    pks-modular
                                                                                    Genes
                                                                                    borA6
                                                                                    Substrates
                                                                                    Integrated Monomers
                                                                                    Domains
                                                                                    acyltransferase, ketosynthase, acyltransferase, ketoreductase, carrier (ACP)
                                                                                    Annotation changelog

                                                                                    Entry version: 4

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 3

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Removed trailing whitespace in gene names
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2022-09-15
                                                                                    Updated bioactivity data
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Migrated from v1.4
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2019-10-16
                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2015-06-12
                                                                                    Submitted
                                                                                    • (ID: IROSGRAECON7XFWB774QFHDN)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    Detailed domain annotation
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