Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000031.1:
Cluster 1Polyketide174787

BGC0000031, borrelidin biosynthetic gene cluster from Streptomyces parvulus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Borrelidin
SMILES string: Copy to clipboard
Molecular formula: C28H43NO6
Exact molecular mass: 490.64 Da ([M+H]+)
Molecular activity: Antibacterial, Cytotoxic
Molecular target: Threonyl-tRNA synthetase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Trans-cyclopentane-(1R,2R)-dicarboxylic acid
Thioesterase type:
Type I & II
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
borA1 (CAE45667.1)
Module A0
AT specificity: Trans-cyclopentane-(1R, 2R)-dicarboxylic acid
Evidence for specificity: Unknown

borA2 (CAE45668.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
KR stereochemistry: Unknown

borA3 (CAE45669.1)
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

borA4 (CAE45670.1)
Module 4
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown

borA5 (CAE45671.1)
Module 5
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Unknown
Module is iterated
Evidence for iteration: Unknown

borA6 (CAE45672.1)
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Unknown

Gene cluster description

borrelidin (BGC0000031). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AJ580915. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jose A. Salas (University of Oviedo)

Literature references

1. Olano C et al. (2004) Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: cluster analysis and assignment of functions. Chem Biol 11(1):87-97. doi: 10.1016/j.chembiol.2003.12.018.
2. Olano C et al. (2003) Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun (Camb) (22):2780-2.
3. Olano C et al. (2004) Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tu4055: insights into nitrile formation. Mol Microbiol 52(6):1745-56. doi: 10.1111/j.1365-2958.2004.04090.x.