BGC0000032: A23187 biosynthetic gene cluster from Streptomyces chartreusis NRRL 3882
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 68,313 nt. (total: 68,313 nt).
This entry is originally from NCBI GenBank HM452329.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000032
Short description A23187 biosynthetic gene cluster from Streptomyces chartreusis NRRL 3882
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
HM452329.1
via Knock-out studies
Compounds
  • A23187
Species Streptomyces chartreusis NRRL 3882 [taxonomy]
References
Chemical products information
A23187 [synonyms: Calcimycin] Evidence: NMR [1]
Copy SMILES
C29H37N3O6
Chemical database entries
NPAtlas
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEH42470.1
 1 - 2043 (+) peptidase S15
    copy AA seq
    copy Nt seq
    • AEH42471.1
    		 2098 - 3663 (-) CoA ligase
      copy AA seq
      copy Nt seq
      • AEH42472.1
      		 3878 - 4873 (+) oxidoreductase
        copy AA seq
        copy Nt seq
        • AEH42473.1
        • SchA1
        		 5100 - 13928 (+) polyketide synthase
          copy AA seq
          copy Nt seq
          • AEH42474.1
          • SchA2
          		 14292 - 20483 (+) polyketide synthase
            copy AA seq
            copy Nt seq
            • AEH42475.1
            • SchR1
            		 20653 - 21849 (+) TylR family regulator
              copy AA seq
              copy Nt seq
              • AEH42476.1
              • SchU1
              		 21871 - 22422 (-) hypothetical protein
                copy AA seq
                copy Nt seq
                • AEH42477.1
                • SchM
                		 22502 - 23191 (-) N-methyl-transferase
                  copy AA seq
                  copy Nt seq
                  • AEH42478.1
                  • SchR2
                  		 23726 - 26848 (+) luxR family regulator
                    copy AA seq
                    copy Nt seq
                    • AEH42479.1
                    • SchB1
                    		 27044 - 28651 (-) anthranilate synthase
                      copy AA seq
                      copy Nt seq
                      • AEH42480.1
                      • SchB2
                      		 28948 - 29628 (-) isochorismatase
                        copy AA seq
                        copy Nt seq
                        • AEH42481.1
                        • SchB3
                        		 29661 - 30473 (-) 2,3-dihydroxybenzoate-2,3-dehydrogenase
                          copy AA seq
                          copy Nt seq
                          • AEH42482.1
                          • SchB4
                          		 30511 - 31725 (-) 3-deoxy-D-arabino-heptulosonate 7-phosphate
                            copy AA seq
                            copy Nt seq
                            • AEH42483.1
                            • SchN1
                            		 32036 - 33175 (+) acyl-CoA dehydrogenase
                              copy AA seq
                              copy Nt seq
                              • AEH42484.1
                              • SchN2
                              		 33175 - 34659 (+) adenylation for L-proline
                                copy AA seq
                                copy Nt seq
                                • AEH42485.1
                                • SchN3
                                		 34679 - 34942 (+) proline carrier protein
                                  copy AA seq
                                  copy Nt seq
                                  • AEH42486.1
                                  • SchU2
                                  		 35026 - 35568 (+) hypothetical protein
                                    copy AA seq
                                    copy Nt seq
                                    • AEH42487.1
                                    • SchA3
                                    		 35903 - 40759 (+) polyketide synthase
                                      copy AA seq
                                      copy Nt seq
                                      • AEH42488.1
                                      • SchT
                                      		 40840 - 43089 (-) transmembrane transport protein
                                        copy AA seq
                                        copy Nt seq
                                        • AEH42489.1
                                        • SchR3
                                        		 43244 - 43879 (+) TetR family regulator
                                          copy AA seq
                                          copy Nt seq
                                          • AEH42490.1
                                          • SchA4
                                          		 44006 - 48922 (-) polyketide synthase
                                            copy AA seq
                                            copy Nt seq
                                            • AEH42491.1
                                            • SchA5
                                            		 48948 - 60818 (-) polyketide synthase
                                              copy AA seq
                                              copy Nt seq
                                              • AEH42492.1
                                              • SchU3
                                              		 61022 - 63007 (+) hypothetical protein
                                                copy AA seq
                                                copy Nt seq
                                                • AEH42493.1
                                                • SchF
                                                		 63121 - 64458 (+) 3-carboxymuconate cycloisomerase
                                                  copy AA seq
                                                  copy Nt seq
                                                  • AEH42494.1
                                                  • SchG
                                                  		 64472 - 65227 (-) type II thioesterase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • AEH42495.1
                                                    		 65313 - 65531 (-) hypothetical protein
                                                      copy AA seq
                                                      copy Nt seq
                                                      • AEH42496.1
                                                      		 65765 - 66229 (+) hypothetical protein
                                                        copy AA seq
                                                        copy Nt seq
                                                        • AEH42497.1
                                                        		 66226 - 66864 (-) chorismate mutase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • AEH42498.1
                                                          		 66931 - 68313 (-) peptidase M20
                                                            copy AA seq
                                                            copy Nt seq
                                                            Biosynthesis information
                                                            Annotation changelog

                                                            Entry version: next

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2024-06-14
                                                            MIBiG v4 annotathon
                                                            • (ID: QONZWIJ4YDMWWMH7C7NPUTYT)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 4

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-10-07
                                                            Update chemical activity to schema version 2.11
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 3

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2022-09-15
                                                            Updated bioactivity data
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2022-09-15
                                                            Added AMP-binding domain substrate specificities
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 2

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2019-10-16
                                                            Migrated from v1.4
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            2019-10-16
                                                            Updated compound(s) information (NPAtlas curation)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                            Entry version: 1

                                                            Date
                                                            Changes
                                                            Submitters
                                                            Reviewers
                                                            2015-06-12
                                                            Submitted
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                            Detailed domain annotation
                                                            Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                            A domain glossary is available here, and an explanation of the visualisation is available here.
                                                            Selected features only
                                                            Show module domains
                                                            Similar known gene clusters from MIBiG 4.0
                                                            Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                            Click on reference genes to show details of similarities to genes within the current region.
                                                            Click on an accession to open that entry in the MiBIG database.