BGC0000035 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000035 (Streptomyces bikiniensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	85,915	High	chalcomycin A	PKS

BGC0000035 - Region 1 - T1PKS

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Location: 1 - 85,915 nt. (total: 85,915 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 85,916
Label		BGC0000035

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

ORF3: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

chmCII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

chmHI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

chmPI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

chmPII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

chmU: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase glycosyltransferase transferase

chmAI: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

chmCIII: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

chmCIV: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

chmN: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

Hydrolases: esterase

ORF13: thioesterase

smcogs: SMCOG1004: thioesterase

chmI: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

chmAII: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

chmD: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

chmGI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

chmGII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

chmGIII: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

chmGIV: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

chmGV: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000035.5	1.00	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0000047.5	0.79	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001396.5	0.71	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000035.5	1.00	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0000047.5	0.81	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001396.5	0.72	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000166.5	0.71	PKS	tylactone	Streptomyces fradiae
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 3621 - 83439:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - pk) + (ccmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (mal)
Non-colinear ordering:: chmGI + chmGII + chmGIII + chmGIV + chmGV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

chmGI: pk - mmal - pk

PKS_AT (581..875): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.2
Ethylmalonyl-CoA: 172.2
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 105.5
CHC-CoA: 101.9
Propionyl-CoA: 96.1
Malonyl-CoA: 94.5
trans-1,2-CPDA: 92.2
Isobutyryl-CoA: 79.1
Benzoyl-CoA: 49.0
fatty_acid: 43.4
inactive: 30.7
Acetyl-CoA: 29.5
3-Methylbutyryl-CoA: 27.4

PKS_AT (1592..1887): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.8
Ethylmalonyl-CoA: 191.0
Methoxymalonyl-CoA: 164.4
2-Methylbutyryl-CoA: 124.9
Malonyl-CoA: 109.0
CHC-CoA: 108.0
Propionyl-CoA: 105.8
trans-1,2-CPDA: 104.7
Isobutyryl-CoA: 77.0
Benzoyl-CoA: 57.9
fatty_acid: 51.3
Acetyl-CoA: 38.7
3-Methylbutyryl-CoA: 31.7
inactive: 26.6

PKS_AT (3093..3387): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 87.5%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 188.6
Ethylmalonyl-CoA: 172.4
Methoxymalonyl-CoA: 159.5
2-Methylbutyryl-CoA: 105.3
CHC-CoA: 101.1
Propionyl-CoA: 96.1
Malonyl-CoA: 94.5
trans-1,2-CPDA: 92.9
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 48.9
fatty_acid: 43.1
inactive: 30.2
Acetyl-CoA: 29.7
3-Methylbutyryl-CoA: 26.5

chmGII: mal

PKS_AT (565..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.7
inactive: 112.3
Methoxymalonyl-CoA: 67.8
Methylmalonyl-CoA: 64.4
Propionyl-CoA: 44.1
Acetyl-CoA: 29.9
Isobutyryl-CoA: 27.1
Ethylmalonyl-CoA: 20.8
trans-1,2-CPDA: 19.8
2-Methylbutyryl-CoA: 19.4
fatty_acid: 18.3
CHC-CoA: 14.8
Benzoyl-CoA: 9.0
3-Methylbutyryl-CoA: 7.5

chmGIII: mmal - mmal

PKS_AT (580..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.9
Ethylmalonyl-CoA: 192.5
Methoxymalonyl-CoA: 169.1
2-Methylbutyryl-CoA: 123.9
Malonyl-CoA: 118.3
CHC-CoA: 111.7
Propionyl-CoA: 105.4
trans-1,2-CPDA: 103.8
Isobutyryl-CoA: 83.8
Benzoyl-CoA: 62.9
fatty_acid: 61.0
Acetyl-CoA: 48.2
3-Methylbutyryl-CoA: 32.3
inactive: 31.8

PKS_AT (2072..2367): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.8
Ethylmalonyl-CoA: 191.0
Methoxymalonyl-CoA: 164.4
2-Methylbutyryl-CoA: 124.9
Malonyl-CoA: 109.0
CHC-CoA: 108.0
Propionyl-CoA: 105.8
trans-1,2-CPDA: 104.7
Isobutyryl-CoA: 77.0
Benzoyl-CoA: 57.9
fatty_acid: 51.3
Acetyl-CoA: 38.7
3-Methylbutyryl-CoA: 31.7
inactive: 26.6

chmGIV: mmal

PKS_AT (565..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.6
Ethylmalonyl-CoA: 189.0
Methoxymalonyl-CoA: 163.8
2-Methylbutyryl-CoA: 126.2
CHC-CoA: 114.4
Malonyl-CoA: 110.0
Propionyl-CoA: 108.5
trans-1,2-CPDA: 102.1
Isobutyryl-CoA: 70.7
Benzoyl-CoA: 56.1
fatty_acid: 53.1
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 32.4
inactive: 26.6

chmGV: mal

PKS_AT (579..889): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.7
inactive: 104.7
Methoxymalonyl-CoA: 69.6
Methylmalonyl-CoA: 57.7
Propionyl-CoA: 38.9
Benzoyl-CoA: 24.4
Ethylmalonyl-CoA: 22.0
Isobutyryl-CoA: 19.8
Acetyl-CoA: 16.9
2-Methylbutyryl-CoA: 14.7
CHC-CoA: 10.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor