BGC0000035: chalcomycin A biosynthetic gene cluster from Streptomyces bikiniensis
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Location: 1 - 85,915 nt. (total: 85,915 nt).
This entry is originally from NCBI GenBank AY509120.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000035
Short description chalcomycin A biosynthetic gene cluster from Streptomyces bikiniensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AY509120.1
via
Compounds
  • chalcomycin A
Species Streptomyces bikiniensis [taxonomy]
References
Chemical products information
chalcomycin A Evidence:
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C35H56O14
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAS79439.1
  • ORF1
 1 - 1009 (-) conserved hypothetical protein
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    • AAS79440.1
    • ORF2
    		 1121 - 1963 (-) conserved hypothetical protein
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      • AAS79441.1
      • ORF3
      		 3008 - 3889 (-) conserved hypothetical protein
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        • AAS79442.1
        • chmCIV
        		 3991 - 5208 (-) putative D-chalcose pathway component
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          • AAS79443.1
          • chmCI
          		 5339 - 6118 (-) putative O-methyltransferase in D-chalcose pathway
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            • AAS79444.1
            • chmCV
            		 6239 - 7696 (-) putative D-chalcose pathway component
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              • AAS79445.1
              • chmR
              		 7761 - 10271 (-) putative beta-glucosidase
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                • AAS79446.1
                • chmPII
                		 10306 - 11511 (-) P450
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                  • AAS79447.1
                  • chmPI
                  		 11549 - 12772 (-) P450
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                    • AAS79448.1
                    • chmI
                    		 12762 - 13610 (-) putative thioesterase TEII family
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                      • AAS79449.1
                      • chmAII
                      		 13631 - 14602 (-) putative TDP-glucose 4,6-dehydratase
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                        • AAS79450.1
                        • chmAI
                        		 14645 - 15562 (-) putative TDP-glucose synthase
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                          • AAS79451.1
                          • chmJ
                          		 15869 - 16459 (-) putative 3-epimerase in D-allose pathway
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                            • AAS79452.1
                            • chmMII
                            		 16523 - 17290 (-) putative 3'OH-methyltransferase in D-mycinose pathway
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                              • AAS79453.1
                              • chmHI
                              		 17551 - 18813 (+) P450
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                                • AAS79454.1
                                • chmHII
                                		 18831 - 19052 (+) ferredoxin
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                                  • AAS79455.1
                                  • chmD
                                  		 19049 - 20029 (+) putative 4-ketoreductase in D-allose pathway
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                                    • AAS79456.1
                                    • chmMI
                                    		 20062 - 21273 (+) putative 2'OH-methyltransferase in D-mycinose pathway
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                                      • AAS79457.1
                                      • chmN
                                      		 21329 - 22585 (+) putative D-allose glycosyltransferase
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                                        • AAS79458.1
                                        • chrB
                                        		 22653 - 23495 (-) putative resistance determinant
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                                          • AAS79459.1
                                          • chmGI
                                          		 23622 - 36947 (+) polyketide synthase subunit
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                                            • AAS79460.1
                                            • chmGII
                                            		 37041 - 42965 (+) polyketide synthase subunit
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                                              • AAS79461.1
                                              • chmGIII
                                              		 43022 - 54388 (+) polyketide synthase subunit
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                                                • AAS79462.1
                                                • chmGIV
                                                		 54439 - 59277 (+) polyketide synthase subunit
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                                                  • AAS79463.1
                                                  • chmGV
                                                  		 59387 - 63439 (+) polyketide synthase subunit
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                                                    • AAS79464.1
                                                    • chmCII
                                                    		 63522 - 64760 (+) putative NDP-hexose 3,4-isomerase
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                                                      • AAS79465.1
                                                      • chmCIII
                                                      		 64804 - 66081 (+) putative chalcose glycosyltransferase
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                                                        • AAS79466.1
                                                        • chmU
                                                        		 66194 - 66940 (+) putative post-PKS ketoreductase
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                                                          • AAS79467.1
                                                          • ORF4
                                                          		 67323 - 68471 (-) putative permease
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                                                            • AAS79468.1
                                                            • ORF5
                                                            		 68733 - 70196 (-) conserved hypothetical protein
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                                                              • AAS79469.1
                                                              • ORF6
                                                              		 70193 - 70888 (-) putative D-alanyl-D-alanine carboxypeptidase
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                                                                • AAS79470.1
                                                                • ORF7
                                                                		 71382 - 72542 (-) sensory histidine kinase
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                                                                  • AAS79471.1
                                                                  • ORF8
                                                                  		 72638 - 73324 (-) putative two-component system response regulator
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                                                                    • AAS79472.1
                                                                    • ORF9
                                                                    		 73651 - 75081 (-) putative permease
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                                                                      • AAS79473.1
                                                                      • ORF10
                                                                      		 75401 - 76117 (-) conserved hypothetical protein
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                                                                        • AAS79474.1
                                                                        • ORF11
                                                                        		 76537 - 78375 (+) putative permease
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                                                                          • AAS79475.1
                                                                          • ORF12
                                                                          		 78521 - 79192 (+) putative merR-family transcriptional regulator
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                                                                            • AAS79476.1
                                                                            • ORF13
                                                                            		 79228 - 79983 (-) thioesterase TEII family
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                                                                              • AAS79477.1
                                                                              • ORF14
                                                                              		 80489 - 81439 (-) hypothetical protein
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                                                                                • AAS79478.1
                                                                                • ORF15
                                                                                		 81806 - 82528 (+) putative response regulator
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                                                                                  • AAS79479.1
                                                                                  • ORF16
                                                                                  		 82712 - 85912 (+) hypothetical protein
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                                                                                    Biosynthesis information
                                                                                    Annotation changelog

                                                                                    Entry version: 4

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-10-07
                                                                                    Update chemical activity to schema version 2.11
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 3

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2022-09-15
                                                                                    Updated bioactivity data
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 2

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2019-10-16
                                                                                    Migrated from v1.4
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    2019-10-16
                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                    Entry version: 1

                                                                                    Date
                                                                                    Changes
                                                                                    Submitters
                                                                                    Reviewers
                                                                                    2015-06-12
                                                                                    Submitted
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                    Detailed domain annotation
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