BGC0000036 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000036 (Streptomyces antibioticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS	1	111,968	chlorothricin/deschlorothricin	PKS:Type I+saccharide:oligosaccharide	100%

BGC0000036 - Region 1 - PKS-like,T1PKS

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Location: 1 - 111,968 nt. (total: 111,968 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 111,969
Label		BGC0000036

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000036	1.62	Polyketide, Saccharide	chlorothricin, deschlorothricin	Streptomyces antibioticus
BGC0000016	1.15	Other	amphotericin B	Streptomyces nodosus
BGC0002081	1.01	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0001273	0.95	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.94	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.92	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0002229	0.87	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000278	0.85	Polyketide	urdamycin	Streptomyces fradiae
BGC0000170	0.83	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0002615	0.83	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000036	1.00	Polyketide, Saccharide	chlorothricin, deschlorothricin	Streptomyces antibioticus
BGC0000041	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000016	0.71	Other	amphotericin B	Streptomyces nodosus
BGC0002081	0.67	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0000019	0.66	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001276	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0002211	0.65	Polyketide	HEx-pks1 polyketide	Paraphaeosphaeria sporulosa
BGC0001275	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002608	0.65	NRP, Polyketide	ochratoxin A	Aspergillus steynii

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 111968:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (ccmal - redmal) + (redmal - ccmal - ccmal) + (ccmal) + (redmal - pk) + (ohmal) + (pk)
Non-colinear ordering:: AAZ77693.1 + AAZ77694.1 + AAZ77696.1 + AAZ77697.1 + AAZ77698.1 + AAZ77699.1 + AAZ77673.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 35794:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (pk)
Non-colinear ordering:: AAZ77693.1 + AAZ77673.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 0 - 30470:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 11480 - 111968:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (ccmal - redmal) + (redmal - ccmal - ccmal) + (ccmal) + (redmal - pk) + (ohmal)
Non-colinear ordering:: AAZ77693.1 + AAZ77694.1 + AAZ77696.1 + AAZ77697.1 + AAZ77698.1 + AAZ77699.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAZ77673.1

PKS_AT (557..849): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 75.0%; Ethylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 125.6
Methoxymalonyl-CoA: 98.7
Ethylmalonyl-CoA: 96.3
Malonyl-CoA: 91.9
Propionyl-CoA: 55.8
trans-1,2-CPDA: 54.7
2-Methylbutyryl-CoA: 54.1
Benzoyl-CoA: 47.4
Isobutyryl-CoA: 44.1
inactive: 40.1
Acetyl-CoA: 30.8
3-Methylbutyryl-CoA: 30.4
CHC-CoA: 26.1
fatty_acid: 24.1

AAZ77693.1

PKS_AT (587..885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.9
inactive: 123.8
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 57.3
Propionyl-CoA: 33.7
Isobutyryl-CoA: 30.4
Ethylmalonyl-CoA: 22.6
Benzoyl-CoA: 21.7
Acetyl-CoA: 20.2
2-Methylbutyryl-CoA: 14.0
CHC-CoA: 12.6
trans-1,2-CPDA: 10.1
fatty_acid: 8.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (1639..1938): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 240.7
Methylmalonyl-CoA: 233.4
Methoxymalonyl-CoA: 194.5
2-Methylbutyryl-CoA: 172.4
trans-1,2-CPDA: 139.6
Propionyl-CoA: 128.1
Malonyl-CoA: 115.4
CHC-CoA: 115.4
Isobutyryl-CoA: 94.8
Benzoyl-CoA: 69.7
3-Methylbutyryl-CoA: 52.9
Acetyl-CoA: 46.7
fatty_acid: 43.6
inactive: 28.9

PKS_AT (3425..3710): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.6
inactive: 80.2
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 59.4
Propionyl-CoA: 35.1
Isobutyryl-CoA: 26.5
Acetyl-CoA: 19.5
Benzoyl-CoA: 18.0
fatty_acid: 16.9
trans-1,2-CPDA: 13.1
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 0.1
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.1

AAZ77694.1

PKS_AT (573..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 79.1
Methoxymalonyl-CoA: 74.2
Methylmalonyl-CoA: 59.7
Propionyl-CoA: 39.4
Isobutyryl-CoA: 37.9
Acetyl-CoA: 19.5
Benzoyl-CoA: 18.9
fatty_acid: 17.2
trans-1,2-CPDA: 15.0
CHC-CoA: 12.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.1
Ethylmalonyl-CoA: -3.1

PKS_AT (2322..2610): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.4
inactive: 88.6
Methoxymalonyl-CoA: 82.9
Methylmalonyl-CoA: 67.5
Isobutyryl-CoA: 44.1
Propionyl-CoA: 37.3
Benzoyl-CoA: 21.9
trans-1,2-CPDA: 18.8
Acetyl-CoA: 17.7
fatty_acid: 16.8
CHC-CoA: 12.2
3-Methylbutyryl-CoA: 7.6
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77696.1

PKS_AT (565..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.4
inactive: 76.3
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 59.1
Propionyl-CoA: 36.7
Isobutyryl-CoA: 28.0
Benzoyl-CoA: 20.4
Acetyl-CoA: 20.1
fatty_acid: 15.6
CHC-CoA: 12.4
trans-1,2-CPDA: 12.3
2-Methylbutyryl-CoA: 7.6
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -4.5

PKS_AT (2674..2959): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.3
inactive: 75.4
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 59.4
Propionyl-CoA: 41.0
Isobutyryl-CoA: 39.1
Benzoyl-CoA: 21.2
Acetyl-CoA: 20.1
fatty_acid: 16.0
trans-1,2-CPDA: 14.1
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

PKS_AT (4429..4713): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.0
Methoxymalonyl-CoA: 83.0
inactive: 77.1
Methylmalonyl-CoA: 64.7
Isobutyryl-CoA: 38.2
Propionyl-CoA: 37.3
Benzoyl-CoA: 22.5
Acetyl-CoA: 20.0
trans-1,2-CPDA: 18.7
fatty_acid: 16.5
CHC-CoA: 12.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77697.1

PKS_AT (566..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.2
inactive: 83.6
Methoxymalonyl-CoA: 81.6
Methylmalonyl-CoA: 63.1
Propionyl-CoA: 40.0
Isobutyryl-CoA: 34.8
Benzoyl-CoA: 16.7
fatty_acid: 15.1
Acetyl-CoA: 14.5
trans-1,2-CPDA: 13.9
CHC-CoA: 9.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77698.1

PKS_AT (564..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.6
inactive: 80.2
Methoxymalonyl-CoA: 80.0
Methylmalonyl-CoA: 59.3
Propionyl-CoA: 36.5
Isobutyryl-CoA: 29.4
Benzoyl-CoA: 16.7
fatty_acid: 15.4
Acetyl-CoA: 14.8
trans-1,2-CPDA: 13.7
CHC-CoA: 9.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -4.5

PKS_AT (2659..2955): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.5
Methylmalonyl-CoA: 217.5
Methoxymalonyl-CoA: 182.4
trans-1,2-CPDA: 150.1
2-Methylbutyryl-CoA: 146.1
CHC-CoA: 129.6
Propionyl-CoA: 119.2
Malonyl-CoA: 108.8
Isobutyryl-CoA: 86.4
Benzoyl-CoA: 65.4
Acetyl-CoA: 64.5
fatty_acid: 37.3
3-Methylbutyryl-CoA: 36.7
inactive: 35.7

AAZ77699.1

PKS_AT (568..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.3
inactive: 113.4
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 44.3
Isobutyryl-CoA: 20.1
Acetyl-CoA: 17.5
Ethylmalonyl-CoA: 16.9
Propionyl-CoA: 15.7
Benzoyl-CoA: 14.2
2-Methylbutyryl-CoA: 13.8
fatty_acid: 12.8
CHC-CoA: 11.2
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0