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The order of the extracellular reactions has been deduced accordin to the accumulated intermediates in directed mutants (unpublished)"}],"steps":"cpkA > cpkB > cpkC > cpkE > cpkG > cpkF > cpkD > scF > cpkH","references":["doi:10.1039/c2sc20410j","pubmed:17093047"],"isSubcluster":false,"producesPrecursor":false}]},"compounds":[{"name":"coelimycin P1","evidence":[{"method":"NMR","references":["doi:10.1039/c2sc20410j"]},{"method":"Mass spectrometry","references":["doi:10.1039/c2sc20410j"]}],"bioactivities":[{"name":"pigment","observed":true,"references":["doi:10.1039/c2sc20410j"]},{"name":"pigment","observed":true,"references":["doi:10.1099/mic.0.038281-0"]},{"name":"antibacterial","observed":true,"references":["doi:10.1039/c2sc20410j"]},{"name":"antibacterial","observed":true,"references":["doi:10.1099/mic.0.038281-0"]}],"structure":"C/C=C/C(=O)/C/1=C/C(=C\\2/C=CCCN2)/SC[CH](C(=O)O1)NC(=O)C","databaseIds":["chemspider:27475147"],"mass":348.11437811999997,"formula":"C17H20N2O4S"}],"taxonomy":{"name":"Streptomyces coelicolor A3(2)","ncbiTaxId":100226},"genes":{"annotations":[{"id":"CAB60184.1","name":"SCO6265","product":"ScbR; Butyrolactone-responsive repressor protein","functions":[{"function":{"name":"Regulation"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAB60185.1","name":"SCO6266","product":"ScbA; Butenolide synthase involved in SCB1 biosynthesis"},{"id":"CAB60186.1","name":"SCO6267","product":"ScbB; Reductase involved in SCB1 biosynthesis"},{"id":"CAB60187.1","name":"SCO6268","product":"CpkM; Two-component system histidine kinase","functions":[{"function":{"name":"Regulation"},"evidence":[]}]},{"id":"CAB60188.1","name":"SCO6269","product":"CpkP-beta; beta-Ketoacid-dependent ferredoxin reductase beta-subunit","functions":[{"function":{"name":"Precursor biosynthesis"},"evidence":[]}]},{"id":"CAB60189.1","name":"SCO6270","product":"CpkP-alpha; alpha-Ketoacid-dependent ferredoxin reductase alpha-subunit","functions":[{"function":{"name":"Precursor biosynthesis"},"evidence":[]}]},{"id":"CAD55505.1","name":"SCO6271","product":"AccA1; Acyl-CoA carboxylase alpha-subunit (biotinylated)","functions":[{"function":{"name":"Precursor biosynthesis"},"evidence":[]}]},{"id":"CAC22143.1","name":"SCO6272","product":"ScF; Secreted flavin-dependent epoxidase/dehydrogenase","functions":[{"function":{"name":"Tailoring"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAC22144.1","name":"SCO6273","product":"CpkC; Polyketide synthase module 5","functions":[{"function":{"name":"Scaffold biosynthesis"},"evidence":[]}]},{"id":"CAC22145.1","name":"SCO6274","product":"CpkB; Polyketide synthase modules 3 and 4","functions":[{"function":{"name":"Scaffold biosynthesis"},"evidence":[]}]},{"id":"CAD55506.1","name":"SCO6275","product":"CpkA; Polyketide synthase loading module, and modules 1 and 2","functions":[{"function":{"name":"Scaffold biosynthesis"},"evidence":[]}]},{"id":"CAC37877.1","name":"SCO6276","product":"CpkD; Secreted flavin-dependent epoxidase/dehydrogenase","functions":[{"function":{"name":"Tailoring"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAC37878.1","name":"SCO6277","product":"CpkE; Putative isomerase (alpha, beta-hydrolase fold)","functions":[{"function":{"name":"Tailoring"},"evidence":[]}]},{"id":"CAC37879.1","name":"SCO6278","product":"CpkF; Transmembrane efflux protein","functions":[{"function":{"name":"Transport"},"evidence":[]}]},{"id":"CAC37880.1","name":"SCO6279","product":"CpkG; Pyridoxal-dependent aminotransferase","functions":[{"function":{"name":"Tailoring"},"evidence":[]}]},{"id":"CAC37881.1","name":"SCO6280","product":"CpkO; KasO; SARP-family transcriptional activator","functions":[{"function":{"name":"Regulation"},"evidence":[]}]},{"id":"CAC37882.1","name":"SCO6281","product":"CpkH; Secreted flavin-dependent epoxidase/dehydrogenase","functions":[{"function":{"name":"Tailoring"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAC37883.1","name":"SCO6282","product":"CpkI; Nicotinamide-dependent dehydrogenase"},{"id":"CAC37884.1","name":"SCO6283","product":"CpkJ; NmrA-family protein (unknown function)"},{"id":"CAC37885.1","name":"SCO6284","product":"CpkK; Acyl-CoA carboxylase beta-subunit","functions":[{"function":{"name":"Precursor biosynthesis"},"evidence":[]}]},{"id":"CAC37886.1","name":"SCO6285","product":"CpkL; Hypothetical protein (unknown function)"},{"id":"CAC37887.1","name":"SCO6286","product":"ScbR2; Butyrolactone-responsive repressor protein","functions":[{"function":{"name":"Regulation"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAC37888.1","name":"SCO6287","product":"ScoT; Type II thioesterase","functions":[{"function":{"name":"Scaffold biosynthesis"},"evidence":[{"method":"Knock-out"}]}]},{"id":"CAC37890.1","name":"SCO6288","product":"CpkN; SARP-family transcriptional activator","functions":[{"function":{"name":"Regulation"},"evidence":[]}]}]},"legacy_references":["pubmed:17009021","pubmed:20447997","pubmed:24660171"]}