BGC0000038: coelimycin P1 biosynthetic gene cluster from Streptomyces coelicolor A3(2)
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Location: 6,890,528 - 6,948,414 nt. (total: 57,887 nt).
This entry is originally from NCBI GenBank AL645882.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000038
Short description coelimycin P1 biosynthetic gene cluster from Streptomyces coelicolor A3(2)
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AL645882.2
6890528 - 6948414
via Knock-out studies
Compounds
  • coelimycin P1
Species Streptomyces coelicolor A3(2) [taxonomy]
References
Chemical products information
coelimycin P1 Evidence: NMR [1], Mass spectrometry [1]
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C17H20N2O4S1
Chemical database entries
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAB60184.1
  • SCO6265
 6890528 - 6891175 (-) ScbR; Butyrolactone-responsive repressor protein
  • Regulation
  • Knock-out
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  • CAB60185.1
  • SCO6266
 6891293 - 6892237 (+) ScbA; Butenolide synthase involved in SCB1 biosynthesis
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    • CAB60186.1
    • SCO6267
    		 6892353 - 6893207 (+) ScbB; Reductase involved in SCB1 biosynthesis
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      • CAB60187.1
      • SCO6268
      		 6893258 - 6894022 (-) CpkM; Two-component system histidine kinase
      • Regulation
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      • CAB60188.1
      • SCO6269
      		 6894148 - 6895200 (-) CpkP-beta; beta-Ketoacid-dependent ferredoxin reductase beta-subunit
      • Precursor biosynthesis
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      • CAB60189.1
      • SCO6270
      		 6895193 - 6897085 (-) CpkP-alpha; alpha-Ketoacid-dependent ferredoxin reductase alpha-subunit
      • Precursor biosynthesis
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      • CAD55505.1
      • SCO6271
      		 6897089 - 6898861 (-) AccA1; Acyl-CoA carboxylase alpha-subunit (biotinylated)
      • Precursor biosynthesis
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      • CAC22143.1
      • SCO6272
      		 6899170 - 6900822 (+) ScF; Secreted flavin-dependent epoxidase/dehydrogenase
      • Tailoring
      • Knock-out
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      • CAC22144.1
      • SCO6273
      		 6900898 - 6907356 (-) CpkC; Polyketide synthase module 5
      • Scaffold biosynthesis
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      • CAC22145.1
      • SCO6274
      		 6907413 - 6918143 (-) CpkB; Polyketide synthase modules 3 and 4
      • Scaffold biosynthesis
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      • CAD55506.1
      • SCO6275
      		 6918286 - 6931959 (-) CpkA; Polyketide synthase loading module, and modules 1 and 2
      • Scaffold biosynthesis
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      • CAC37877.1
      • SCO6276
      		 6932285 - 6933607 (+) CpkD; Secreted flavin-dependent epoxidase/dehydrogenase
      • Tailoring
      • Knock-out
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      • CAC37878.1
      • SCO6277
      		 6933604 - 6934464 (+) CpkE; Putative isomerase (alpha, beta-hydrolase fold)
      • Tailoring
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      • CAC37879.1
      • SCO6278
      		 6934507 - 6936138 (+) CpkF; Transmembrane efflux protein
      • Transport
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      • CAC37880.1
      • SCO6279
      		 6936149 - 6937705 (+) CpkG; Pyridoxal-dependent aminotransferase
      • Tailoring
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      • CAC37881.1
      • SCO6280
      		 6938012 - 6939643 (+) CpkO; KasO; SARP-family transcriptional activator
      • Regulation
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      • CAC37882.1
      • SCO6281
      		 6939907 - 6941544 (+) CpkH; Secreted flavin-dependent epoxidase/dehydrogenase
      • Tailoring
      • Knock-out
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      • CAC37883.1
      • SCO6282
      		 6941746 - 6942543 (-) CpkI; Nicotinamide-dependent dehydrogenase
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        • CAC37884.1
        • SCO6283
        		 6942661 - 6943506 (+) CpkJ; NmrA-family protein (unknown function)
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          • CAC37885.1
          • SCO6284
          		 6943673 - 6945265 (+) CpkK; Acyl-CoA carboxylase beta-subunit
          • Precursor biosynthesis
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          • CAC37886.1
          • SCO6285
          		 6945280 - 6945543 (+) CpkL; Hypothetical protein (unknown function)
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            • CAC37887.1
            • SCO6286
            		 6945705 - 6946379 (-) ScbR2; Butyrolactone-responsive repressor protein
            • Regulation
            • Knock-out
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            • CAC37888.1
            • SCO6287
            		 6946617 - 6947423 (+) ScoT; Type II thioesterase
            • Scaffold biosynthesis
            • Knock-out
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            • CAC37890.1
            • SCO6288
            		 6947584 - 6948414 (+) CpkN; SARP-family transcriptional activator
            • Regulation
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            Biosynthesis information

            Biosynthetic paths

            Coelimycin
            Show structure
            Pathway: cpkA > cpkB > cpkC > cpkE > cpkG > cpkF > cpkD > scF > cpkH [1], [3]
            Comment: Proposed product of the pathway, prior to adduct formation with N-acetylcysteine; CpkF is an exporter, enzymes ScF and CpkH are extracellular (TAT system) and CpkD is proposed to be also extracellular. The order of the extracellular reactions has been deduced accordin to the accumulated intermediates in directed mutants (unpublished)
            Annotation changelog

            Entry version: next

            Date
            Changes
            Submitters
            Reviewers
            2024-05-14
            MIBiG v4 annotathon
            • (ID: RJXZFYIPTBJ27AV3IUUT4BRL)
            • (ID: 7EVFL2OHJXJOBV2W5352UWGU)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 4

            Date
            Changes
            Submitters
            Reviewers
            2022-10-07
            Update chemical activity to schema version 2.11
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 3

            Date
            Changes
            Submitters
            Reviewers
            2022-09-15
            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Removed duplications from gene synonyms
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            2022-09-15
            Updated bioactivity data
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 2

            Date
            Changes
            Submitters
            Reviewers
            2019-10-16
            Migrated from v1.4
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

            Entry version: 1

            Date
            Changes
            Submitters
            Reviewers
            2015-06-12
            Submitted
            • (ID: RJXZFYIPTBJ27AV3IUUT4BRL)
            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
            Detailed domain annotation
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