Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000038.1:
Cluster 1Polyketide157887

BGC0000038, coelimycin biosynthetic gene cluster from Streptomyces coelicolor. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: coelimycin P1
ChemSpider ID: 27475147
SMILES string: Copy to clipboard
Molecular formula:
Average molecular mass: Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Modular type I
Starter unit:
Malonyl-CoA
Thioesterase type:
Other
Release / cyclization type:
Reductive release

Modular polyketide synthases:
SCO6275 (CAD55506.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 3
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

SCO6274 (CAC22145.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

SCO6273 (CAC22144.1)
Module 6
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

Gene cluster description

coelimycin (BGC0000038). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AL645882, positions 6890528-6948414. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Juan Pablo Gomez-Escribano (John Innes Centre; Norwich Research Park; Norwich; NR4 7UH; UK)

Literature references

1. Pawlik K et al. (2007) A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2). Arch Microbiol 187(2):87-99. doi: 10.1007/s00203-006-0176-7. Epub 2006
2. Gottelt M et al. (2010) Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2). Microbiology 156(Pt 8):2343-53. doi: 10.1099/mic.0.038281-0. Epub 2010
3. Kotowska M et al. (2014 TI) Type II thioesterase ScoT is required for coelimycin production by the modular polyketide synthase Cpk of Streptomyces coelicolor A3(2). Acta Biochim Pol 61(1):141-7. Epub 2014 Mar 21.