BGC0000039 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000039 (Penicillium citrinum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	38,231	compactin	PKS	100%

BGC0000039 - Region 1 - T1PKS

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Location: 1 - 38,231 nt. (total: 38,231 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 38,232
Label		BGC0000039

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039	1.00	Polyketide	compactin	Penicillium citrinum
BGC0002192	0.39	Polyketide	FR901512	fungal sp. No.14919
BGC0000098	0.36	Polyketide	monacolin K	Monascus pilosus
BGC0002745	0.35	Polyketide	verrucosidin	Penicillium polonicum
BGC0002194	0.34	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001254	0.34	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001907	0.34	Polyketide	chromane	Daldinia eschscholzii IFB-TL01
BGC0002258	0.34	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0002525	0.33	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001252	0.33	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039	1.00	Polyketide	compactin	Penicillium citrinum
BGC0002192	0.71	Polyketide	FR901512	fungal sp. No.14919
BGC0000098	0.69	Polyketide	monacolin K	Monascus pilosus
BGC0002745	0.68	Polyketide	verrucosidin	Penicillium polonicum
BGC0002194	0.67	Polyketide	epipyrone A	Epicoccum nigrum
BGC0001254	0.67	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001907	0.67	Polyketide	chromane	Daldinia eschscholzii IFB-TL01
BGC0002258	0.67	Polyketide	shimalactone A, shimalactone B	Aspergillus stellatus
BGC0002525	0.66	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001252	0.66	Polyketide	UNII-YC2Q1O94PT	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 38231:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mlcB + mlcA

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mlcA

PKS_AT (559..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 68.6
Methoxymalonyl-CoA: 55.9
Propionyl-CoA: 18.5
fatty_acid: 17.1
Malonyl-CoA: 15.5
2-Methylbutyryl-CoA: 11.3
Benzoyl-CoA: 9.2
Isobutyryl-CoA: 8.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.4
trans-1,2-CPDA: -3.7

mlcB

PKS_AT (567..894): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 56.3
Methoxymalonyl-CoA: 46.9
Methylmalonyl-CoA: 41.1
inactive: 25.0
Benzoyl-CoA: 19.0
Isobutyryl-CoA: 18.4
Propionyl-CoA: 9.4
fatty_acid: 8.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.6