LOCUS       BGC0000039             38231 bp    DNA     linear   PLN 31-OCT-2002
DEFINITION  Penicillium citrinum ML-236B (compactin) biosynthetic gene cluster
            (mlcH, mlcG, mlcF, mlcA, mlcC, mlcB, mlcD, mlcE, mlcR), complete
            cds.
ACCESSION   BGC0000039
VERSION     BGC0000039
KEYWORDS    .
SOURCE      Penicillium citrinum
  ORGANISM  Penicillium citrinum
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Penicillium.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 15:00:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 38231
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..38231
                     /db_xref="taxon:5077"
                     /mol_type="genomic DNA"
                     /organism="Penicillium citrinum"
     subregion       1..38231
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..38231
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            join(427..601,676..955,1034..1739,1808..1982)
                     /gene="mlcH"
                     /note="putative transesterase"
     gene            427..1982
                     /gene="mlcH"
     CDS             join(463..601,676..955,1034..1739,1808..1939)
                     /codon_start=1
                     /gene="mlcH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 205.3; E-value: 2.1e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative ML-236B biosynthetic gene"
                     /product="transesterase"
                     /protein_id="BAC20561.1"
                     /transl_table=1
                     /translation="MAPSIDVIPTAASTAAGMISDMEAAFKSAVKLKQIPGAVVMARSM
                     NGDIDYTRCFGARTVERDECQRLPPMEIDTPLRLASATKLLTTIMALQCMEQGLVDLDE
                     NVNRLLPDLSDMQVLTGFDAAGNAIMRDREGIIKLRHLLTHTSGLSYAFLHPLLQEYMA
                     KGYLKTAEKFGIQSRLAPPAINDPGVEWIYGANLDWAGKLIERATGVDLEEFMQKNICE
                     PLGITDMTFKLQQRPDMLARRSDQTRRNENGSLRYDDSVYFRHDGEECFGGQGVFCGPE
                     SYMKVLNSLMKHDGLLLKKDTIELMFQPALDAELEKKMNDHMDTTPHINYGAALPPVMR
                     RNFGLGGIIAMGDLDGHNWRREGSLTFGGGPNIVWQIDPTVGLCTLVVFQLEPWNDPIC
                     KDLTRKFEKAMYSQVKCRN"
     mRNA            complement(join(2353..2821,2927..3038,3107..3696))
                     /gene="mlcG"
                     /note="putative enoyl reductase"
     gene            complement(2353..3696)
                     /gene="mlcG"
     CDS             complement(join(2405..2821,2927..3038,3107..3666))
                     /NRPS_PKS="Domain: PKS_ER (29-244). E-value: 1.5e-26.
                     Score: 85.0. Matches aSDomain:
                     nrpspksdomains_mlcG_PKS_ER.1"
                     /codon_start=1
                     /gene="mlcG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 217.3; E-value: 4.8e-66)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative ML-236B biosynthetic gene"
                     /product="enoyl reductase"
                     /protein_id="BAC20562.1"
                     /sec_met_domain="ADH_N (E-value: 1e-11, bitscore: 34.1,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 5.3e-13, bitscore:
                     38.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MGVAMTEGSFIPPVKQTILTVNDKDEVVIWDDAPTPKLPADQVYV
                     RIHAVAVNPSDTKMRGDFATPFACLGTDYAGTVVAVGSEITHVKVGDRVFGAQNEMCPR
                     TPEQGAFSQYTITRGRIWAKIPDSMTWEAAASLPAGISTTGLAMKLLGMPLPYSETKPS
                     KKTYVLIYGGSTATATIAMQFMRLSGYTPIATCSHKNFDLAKKNGAEEVFDYRDADCAQ
                     KIRDYTRNNLAYALDCIINVESTSTCYKAIGRAGGRYVALNPFPEHAATRKMVTSDWTL
                     GPTIFGEGSTWPAPYGCEASEEVRLFGTELWQVASRLVEEDKLYHHPLRVIDGGLEQVK
                     QGMETVRNGELSGEKIVVRFSV"
     aSDomain        complement(join(2762..2821,2927..3038,3107..3579))
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcG_PKS_ER.1"
                     /evalue="1.50E-26"
                     /label="mlcG_PKS_ER.1"
                     /locus_tag="mlcG"
                     /protein_end="244"
                     /protein_start="29"
                     /score="85.0"
                     /tool="antismash"
                     /translation="WDDAPTPKLPADQVYVRIHAVAVNPSDTKMRGDFATPFACLGTDY
                     AGTVVAVGSEITHVKVGDRVFGAQNEMCPRTPEQGAFSQYTITRGRIWAKIPDSMTWEA
                     AASLPAGISTTGLAMKLLGMPLPYSETKPSKKTYVLIYGGSTATATIAMQFMRLSGYTP
                     IATCSHKNFDLAKKNGAEEVFDYRDADCAQKIRDYTRNNLAYALDCIINVES"
     CDS_motif       complement(3421..3459)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcG_0001"
                     /evalue="4.70E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="mlcG"
                     /protein_end="82"
                     /protein_start="69"
                     /score="10.0"
                     /tool="antismash"
                     /translation="LGTDYAGTVVAVG"
     mRNA            4068..4980
                     /gene="mlcF"
                     /note="putative oxidoreductase"
     gene            4068..4980
                     /gene="mlcF"
     CDS             4120..4875
                     /codon_start=1
                     /gene="mlcF"
                     /note="putative ML-236B biosynthetic gene"
                     /product="oxidoreductase"
                     /protein_id="BAC20563.1"
                     /transl_table=1
                     /translation="MSPARITDFSPGKPRKALLCIHGAGCSAAIFRVQISKLRVALKNE
                     FEFVYATAPFSSSPGPGVLPVFQGMGPYYTWFQKHHDAVTNTTTPTVGDRVAAVIGPVQ
                     KTVQDWSITNPQAPIVGIVAFSEGALVATLLLHQQQMGKLPWFPKMSIAVLICCFYSDE
                     ARDYMRAEAQDDDDKLIINVPTLHLHGRQDFALQGSRQMVETHYLPQNADVLEFQGKHN
                     FPNRPSDVQETVKRFQQLYQKVKMSGSFV"
     mRNA            complement(join(5322..7259,7315..7717,7777..8119,
                     8190..10470,10532..10752,10811..13604,13669..14010,
                     14088..14313,14385..14597,14665..15318))
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcA"
                     /product="polyketide synthase"
     gene            complement(5322..15318)
                     /gene="mlcA"
     CDS             complement(join(5506..7259,7315..7717,7777..8119,
                     8190..10470,10532..10752,10811..13604,13669..14010,
                     14088..14313,14385..14597,14665..15186))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (10-448). E-value:
                     1.4e-166. Score: 546.4. Matches aSDomain:
                     nrpspksdomains_mlcA_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (559-880). E-value: 1.2e-81.
                     Score: 266.1. Matches aSDomain:
                     nrpspksdomains_mlcA_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (952-1132). E-value: 2e-19.
                     Score: 62.4. Matches aSDomain:
                     nrpspksdomains_mlcA_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1392-1613). E-value: 1.5e-102.
                     Score: 334.9. Matches aSDomain: nrpspksdomains_mlcA_cMT.1"
                     /NRPS_PKS="Domain: PKS_KR (2143-2324). E-value: 5.1e-48.
                     Score: 155.2. Matches aSDomain:
                     nrpspksdomains_mlcA_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2446-2520). E-value: 2e-11.
                     Score: 35.9. Matches aSDomain:
                     nrpspksdomains_mlcA_PKS_PP.1"
                     /NRPS_PKS="Domain: Condensation_LCL (2585-2889). E-value:
                     4e-44. Score: 142.7. Matches aSDomain:
                     nrpspksdomains_mlcA_Condensation_LCL.1"
                     /codon_start=1
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcA"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 226.3; E-value:
                     1.1e-68)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="BAC20564.1"
                     /sec_met_domain="Condensation (E-value: 2.9e-39, bitscore:
                     124.1, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.9e-07, bitscore:
                     20.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 2e-82, bitscore: 266.1,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 4.9e-176, bitscore:
                     574.8, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3.7e-43, bitscore:
                     136.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDQANYPNEPIVVVGSGCRFPGGVNTPSKLWELLKEPRDVQTKIP
                     KERFDVDTFYSPDGTHPGRTNAPFAYLLQEDLRGFDASFFNIQAGEAETIDPQQRLLLE
                     TVYEAVSNAGLRIQGLQGSSTAVYVGMMTHDYETIVTRELDSIPTYSATGVAVSVASNR
                     VSYFFDWHGPSMTIDTACSSSLAAVHLAVQQLRTGESTMAVAAGANLILGPMTFVMESK
                     LNMLSPNGRSRMWDAAADGYARGEGVCSIVLKTLSQALRDGDSIECVIRETGINQDGRT
                     TGITMPNHSAQEALIRATYAKAGLDITNPQERCQFFEAHGTGTPAGDPQEAEAIATAFF
                     GHKDGTIDSDGEKDELFVGSIKTVLGHTEGTAGIAGLMKASFAVRNGVIPPNLLFEKIS
                     PRVAPFYTHLKIATEATEWPIVAPGQPRRVSVNSFGFGGTNAHAIIEEYMAPPHKPTAV
                     VTEVTSDADACSLPLVLSSKSQRSMKATLENMLQFLETHDDVDMHDIAYTLLEKRSILP
                     FRRAIAAHNKEVARAALEAAIADGEVVTDFRTDANDNPRVLGVFTGQGAQWPGMLKKLM
                     VGMPFVRGILEELDNSLQTLPEKYRPTWTLYDQLMLEGDASNVRLASFSQPLCCAVQIV
                     LVRLLAAAGIEFSAIVGHSSGEIACAFAAGFISATQAIRIAHLRGVVSAEHASSPSGQT
                     GAMLAAGMSYDDAKELCELEAFEGRVCVAASNSPDSVTFSGDMDAIQHVEGVLEDESTF
                     ARILRVDKAYHSHHMHPCAAPYVKALLECDCAVADGQGNDSVAWFSAVHETSKQMTVQD
                     VMPAYWKDNLVSPVLFSQAVQKAVITHRLIDVAIEIGAHPALKGPCLATIKDALAGVEL
                     PYTGCLARNVDDVDAFAGGLGYIWERFGVRSIDAEGFVQQVRPDRAVQNLSKSLPTYSW
                     DHTRQYWAESRSTRQHLRGGAPHLLLGKLSSYSTASTFQWTNFIRPRDLEWLDGHALQG
                     QTVFPAAGYIIMAMEAAMKVAGERAAQVQLLEILDMSINKAIVFEDENTSVELNLTAEV
                     TSDNDADGQVTVKFVIDSCLAKESELSTSAKGQIVITLGEASPSSQLLPPPEEEYPQMN
                     NVNIDFFYRELDLLGYDYSKDFRRLQTMRRADSKASGTLAFLPLKDELRNEPLLLHPAP
                     LDIAFQTVIGAYSSPGDRRLRSLYVPTHVDRVTLIPSLCISAGNSGETELAFDTINTHD
                     KGDFLSGDITVYDSTKTTLFQVDNIVFKPFSPPTASTDHRIFAKWVWGPLTPEKLLEDP
                     ATLIIARDKEDILTIERIVYFYIKSFLAQITPDDRQNADLHSQKYIEWCDQVQADARAG
                     HHQWYQESWEEDTSVHIEQMCESNSSHPHVRLIQRVGKELISIVRGNGDPLDIMNRDGL
                     FTEYYTNKLAFGSAIHVVQDLVSQIAHRYQSIDILEIGLGTGIATKRVLASPQLGFNSY
                     TCTDISADVIGKAREQLSEFDGLMQFEALDINRSPAEQGFKPHSYDLIIASDVLHASSN
                     FEEKLAHIRSLLKPGGHLVTFGVTHREPARLAFISGLFADRWTGEDETRALSASGSVDQ
                     WEHTLKRVGFSGVDSRTLDREDDLIPSVFSTHAVDATVERLYDPLSAPLKDSYPPLVVI
                     GGESTKTERILNDMKAALPHRHIHSVKRLESVLDDPALQPKSTFVILSELDDEVFCNLE
                     EDKFEAVKSLLFYAGRMMWLTENAWIDHPHQASTIGMLRTIKLENPDLGTHVFDVDTVE
                     NLDTKFFVEQLLRFEESDDQLLESITWTHEPEVYWCKGRAWVPRLKQDIARNDRMNSSR
                     RPIFGNFNSSKTAIALKEARGASSSMYYLESTETCDSLEDARHAGKATVRVRYALPQAI
                     RVGHLGYFHVVQGSILENTCEVPVVALAEKNGSILHVPRNYMHSLPDNMAEGEDSSFLL
                     STAAALLAETILSSAQSFGSDASILIMEPPIFCVKAILESAKTYGVQVHLATTLSDVKT
                     IPAPWIRLHAKETDARLKHSLPTNMMAFFDLSTDRTAAGITNRLAKLLPPSCFMYSGDY
                     LIRSTASTYKVSHVEDIPILEHSVAMAKNTVSASTVDDTEKVITATQILLPGQLSVNHN
                     DQRFNLATVIDWKENEVSARICPIDSGNLFSNKKTYLLVGLTGDLGRSLCRWMILHGAR
                     HVVLTSRNPRLDPKWIANMEALGGDITVLSMDVANEDSVDAGLGKLVDMKLPPVAGIAF
                     GPLVLQDVMLKNMDHQMMDMVLKPKVQGARILHERFSEQTGSKALDFFIMFSSIVAVIG
                     NPGQSNYGAANAYLQALAQQRCARGLAGSTIDIGAVYGVGFVTRAEMEEDFDAIRFMFD
                     SVEEHELHTLFAEAVVSDQRARQQPQRKTVIDMADLELTTGIPDLDPALQDRIIYFNDP
                     RFGNFKIPGQRGDGGDNGSGSKGSIADQLKQATTLDQVRQIVIDGLSEKLRVTLQVSDG
                     ESVDPTIPLIDQGVDSLGAVTVGSWFSKQLYLDLPLLRVLGGASVADLADDAATRLPAT
                     SIPLLLQIGDSTGTSDSGASPTPTDSHDEASSATSTDASSAEEDEEQEDDNEQGGRKIL
                     RRERLSLGQEYSWRQQQMVKDHTIFNNTIGMFMKGTIDLDRLRRALKASLRRHEIFRTC
                     FVTGDDYSSDLNGPVQVVLKNPENRVHFVQVNNAAEAEEEYRKLEKTNYSISTGDTLRL
                     VDFYWGTDDHLLVIGYHRLVGDGSTTENLFNEIGQIYSGVKMQRPSTQFSDLAVQQREN
                     LENGRMGDDIAFWKSMHSKVSSSAPTVLPIMNLINDPAANSEQQQIQPFTWQQYEAIAR
                     LDPMVAFRIKERSRKHKATPMQFYLAAYHVLLARLTGSKDITIGLAETNRSTMEEISAM
                     GFFANVLPLRFDEFVGSKTFGEHLVATKDSVREAMQHARVPYGVILDCLGLNLPTSGEE
                     PKTQTHAPLFQAVFDYKQGQAESGSIGNAKMTSVLASRERTPYDIVLEMWDDPTKDPLI
                     HVKLQSSLYGPEHAQAFVDHFSSILTMFSMNPALKLA"
     aSDomain        complement(5938..6849)
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_Condensation_LCL.1"
                     /domain_subtype="Condensation_LCL"
                     /evalue="4.00E-44"
                     /label="mlcA_Condensation_LCL.1"
                     /locus_tag="mlcA"
                     /protein_end="2889"
                     /protein_start="2585"
                     /score="142.7"
                     /tool="antismash"
                     /translation="RLSLGQEYSWRQQQMVKDHTIFNNTIGMFMKGTIDLDRLRRALKA
                     SLRRHEIFRTCFVTGDDYSSDLNGPVQVVLKNPENRVHFVQVNNAAEAEEEYRKLEKTN
                     YSISTGDTLRLVDFYWGTDDHLLVIGYHRLVGDGSTTENLFNEIGQIYSGVKMQRPSTQ
                     FSDLAVQQRENLENGRMGDDIAFWKSMHSKVSSSAPTVLPIMNLINDPAANSEQQQIQP
                     FTWQQYEAIARLDPMVAFRIKERSRKHKATPMQFYLAAYHVLLARLTGSKDITIGLAET
                     NRSTMEEISAMGFFANVLPLRFD"
     CDS_motif       complement(5944..6033)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0011"
                     /evalue="6.00E-06"
                     /label="C5_LCL_267-296"
                     /locus_tag="mlcA"
                     /protein_end="2887"
                     /protein_start="2857"
                     /score="18.8"
                     /tool="antismash"
                     /translation="DITIGLAETNRSTMEEISAMGFFANVLPLR"
     CDS_motif       complement(6676..6765)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0010"
                     /evalue="3.30E-10"
                     /label="C2_LCL_024-062"
                     /locus_tag="mlcA"
                     /protein_end="2643"
                     /protein_start="2613"
                     /score="32.4"
                     /tool="antismash"
                     /translation="FMKGTIDLDRLRRALKASLRRHEIFRTCFV"
     aSDomain        complement(join(7045..7259,7315..7321))
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_PKS_PP.1"
                     /evalue="2.00E-11"
                     /label="mlcA_PKS_PP.1"
                     /locus_tag="mlcA"
                     /protein_end="2520"
                     /protein_start="2446"
                     /score="35.9"
                     /tool="antismash"
                     /translation="VIDGLSEKLRVTLQVSDGESVDPTIPLIDQGVDSLGAVTVGSWFS
                     KQLYLDLPLLRVLGGASVADLADDAATRL"
     aSModule        7045..15156
                     /complete
                     /domains="nrpspksdomains_mlcA_PKS_KS.1"
                     /domains="nrpspksdomains_mlcA_PKS_AT.1"
                     /domains="nrpspksdomains_mlcA_PKS_DH.1"
                     /domains="nrpspksdomains_mlcA_cMT.1"
                     /domains="nrpspksdomains_mlcA_PKS_KR.1"
                     /domains="nrpspksdomains_mlcA_PKS_PP.1"
                     /iterative
                     /locus_tags="mlcA"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(join(7688..7717,7777..8119,8190..8359))
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_PKS_KR.1"
                     /evalue="5.10E-48"
                     /label="mlcA_PKS_KR.1"
                     /locus_tag="mlcA"
                     /protein_end="2324"
                     /protein_start="2143"
                     /score="155.2"
                     /tool="antismash"
                     /translation="KTYLLVGLTGDLGRSLCRWMILHGARHVVLTSRNPRLDPKWIANM
                     EALGGDITVLSMDVANEDSVDAGLGKLVDMKLPPVAGIAFGPLVLQDVMLKNMDHQMMD
                     MVLKPKVQGARILHERFSEQTGSKALDFFIMFSSIVAVIGNPGQSNYGAANAYLQALAQ
                     QRCARGLAGSTIDIGAVY"
     CDS_motif       complement(7795..7902)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0009"
                     /evalue="8.50E-22"
                     /label="PKSI-KR_m4"
                     /locus_tag="mlcA"
                     /protein_end="2308"
                     /protein_start="2272"
                     /score="69.8"
                     /tool="antismash"
                     /translation="LDFFIMFSSIVAVIGNPGQSNYGAANAYLQALAQQR"
     CDS_motif       complement(8258..8356)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0008"
                     /evalue="2.30E-16"
                     /label="PKSI-KR_m1"
                     /locus_tag="mlcA"
                     /protein_end="2177"
                     /protein_start="2144"
                     /score="52.3"
                     /tool="antismash"
                     /translation="TYLLVGLTGDLGRSLCRWMILHGARHVVLTSRN"
     aSDomain        complement(join(9950..10470,10532..10673))
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="1.50E-102"
                     /label="mlcA_cMT.1"
                     /locus_tag="mlcA"
                     /protein_end="1613"
                     /protein_start="1392"
                     /score="334.9"
                     /tool="antismash"
                     /translation="PLDIMNRDGLFTEYYTNKLAFGSAIHVVQDLVSQIAHRYQSIDIL
                     EIGLGTGIATKRVLASPQLGFNSYTCTDISADVIGKAREQLSEFDGLMQFEALDINRSP
                     AEQGFKPHSYDLIIASDVLHASSNFEEKLAHIRSLLKPGGHLVTFGVTHREPARLAFIS
                     GLFADRWTGEDETRALSASGSVDQWEHTLKRVGFSGVDSRTLDREDDLIPSVFSTHAV"
     aSDomain        complement(11512..12051)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_PKS_DH.1"
                     /evalue="2.00E-19"
                     /label="mlcA_PKS_DH.1"
                     /locus_tag="mlcA"
                     /protein_end="1132"
                     /protein_start="952"
                     /score="62.4"
                     /tool="antismash"
                     /translation="HLLLGKLSSYSTASTFQWTNFIRPRDLEWLDGHALQGQTVFPAAG
                     YIIMAMEAAMKVAGERAAQVQLLEILDMSINKAIVFEDENTSVELNLTAEVTSDNDADG
                     QVTVKFVIDSCLAKESELSTSAKGQIVITLGEASPSSQLLPPPEEEYPQMNNVNIDFFY
                     RELDLLGYDYSKDFRRL"
     CDS_motif       complement(11890..11967)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0007"
                     /evalue="2.60E-10"
                     /label="PKSI-DH_m2"
                     /locus_tag="mlcA"
                     /protein_end="1006"
                     /protein_start="980"
                     /score="32.7"
                     /tool="antismash"
                     /translation="WLDGHALQGQTVFPAAGYIIMAMEAA"
     aSDomain        complement(12268..13230)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_PKS_AT.1"
                     /evalue="1.20E-81"
                     /label="mlcA_PKS_AT.1"
                     /locus_tag="mlcA"
                     /protein_end="880"
                     /protein_start="559"
                     /score="266.1"
                     /tool="antismash"
                     /translation="VFTGQGAQWPGMLKKLMVGMPFVRGILEELDNSLQTLPEKYRPTW
                     TLYDQLMLEGDASNVRLASFSQPLCCAVQIVLVRLLAAAGIEFSAIVGHSSGEIACAFA
                     AGFISATQAIRIAHLRGVVSAEHASSPSGQTGAMLAAGMSYDDAKELCELEAFEGRVCV
                     AASNSPDSVTFSGDMDAIQHVEGVLEDESTFARILRVDKAYHSHHMHPCAAPYVKALLE
                     CDCAVADGQGNDSVAWFSAVHETSKQMTVQDVMPAYWKDNLVSPVLFSQAVQKAVITHR
                     LIDVAIEIGAHPALKGPCLATIKDALAGVELPYTGCLARN"
     CDS_motif       complement(12871..12978)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0006"
                     /evalue="2.30E-08"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="mlcA"
                     /protein_end="679"
                     /protein_start="643"
                     /score="26.6"
                     /tool="antismash"
                     /translation="GIEFSAIVGHSSGEIACAFAAGFISATQAIRIAHLR"
     CDS_motif       complement(13180..13230)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0005"
                     /evalue="1.10E-04"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="mlcA"
                     /protein_end="576"
                     /protein_start="559"
                     /score="14.8"
                     /tool="antismash"
                     /translation="VFTGQGAQWPGMLKKLM"
     aSDomain        complement(join(13564..13604,13669..14010,14088..14313,
                     14385..14597,14665..15156))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcA_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="1.40E-166"
                     /label="mlcA_PKS_KS.1"
                     /locus_tag="mlcA"
                     /protein_end="448"
                     /protein_start="10"
                     /score="546.4"
                     /tool="antismash"
                     /translation="IVVVGSGCRFPGGVNTPSKLWELLKEPRDVQTKIPKERFDVDTFY
                     SPDGTHPGRTNAPFAYLLQEDLRGFDASFFNIQAGEAETIDPQQRLLLETVYEAVSNAG
                     LRIQGLQGSSTAVYVGMMTHDYETIVTRELDSIPTYSATGVAVSVASNRVSYFFDWHGP
                     SMTIDTACSSSLAAVHLAVQQLRTGESTMAVAAGANLILGPMTFVMESKLNMLSPNGRS
                     RMWDAAADGYARGEGVCSIVLKTLSQALRDGDSIECVIRETGINQDGRTTGITMPNHSA
                     QEALIRATYAKAGLDITNPQERCQFFEAHGTGTPAGDPQEAEAIATAFFGHKDGTIDSD
                     GEKDELFVGSIKTVLGHTEGTAGIAGLMKASFAVRNGVIPPNLLFEKISPRVAPFYTHL
                     KIATEATEWPIVAPGQPRRVSVNSFGFGGTNAHAIIEEY"
     CDS_motif       complement(13820..13885)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0004"
                     /evalue="1.80E+01"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="mlcA"
                     /protein_end="384"
                     /protein_start="362"
                     /score="-1.3"
                     /tool="antismash"
                     /translation="TVLGHTEGTAGIAGLMKASFAV"
     CDS_motif       complement(join(13979..14010,14088..14100))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0003"
                     /evalue="3.60E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="mlcA"
                     /protein_end="331"
                     /protein_start="316"
                     /score="10.1"
                     /tool="antismash"
                     /translation="FEAHGTGTPAGDPQE"
     CDS_motif       complement(join(14308..14313,14385..14417))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0002"
                     /evalue="1.20E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="mlcA"
                     /protein_end="247"
                     /protein_start="234"
                     /score="12.1"
                     /tool="antismash"
                     /translation="WDAAADGYARGEG"
     CDS_motif       complement(join(14559..14597,14665..14673))
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcA_0001"
                     /evalue="1.10E-06"
                     /label="PKSI-KS_m3"
                     /locus_tag="mlcA"
                     /protein_end="187"
                     /protein_start="171"
                     /score="20.4"
                     /tool="antismash"
                     /translation="GPSMTIDTACSSSLAA"
     mRNA            join(15658..16167,16234..16405,16469..17633)
                     /gene="mlcC"
                     /note="putative cytochrome P450"
     gene            15658..17633
                     /gene="mlcC"
     CDS             join(15823..16167,16234..16405,16469..17508)
                     /codon_start=1
                     /gene="mlcC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 128.8; E-value: 4.6e-39)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative ML-236B biosynthetic gene"
                     /product="cytochrome P450"
                     /protein_id="BAC20565.1"
                     /sec_met_domain="p450 (E-value: 1.7e-37, bitscore: 118.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MLGQVLLTVESYQWVSTPQALVAVAVLLSLIAYRLRGRQSELQVY
                     NPKKWWELTTMRARQDFDTYGPSWIEAWFSKNDKPLRFIVDSGYCTILPSSMADEFRKI
                     KDMCMYKFLADDFHSHLPGFDGFKEICQDAHLVNKVVLNQLQTQAPKYTKPLATLADAT
                     IAKLFGKSEEWQTAPVYSNGLDLVTRTVTLIMVGDKICHNEEWLDIAKNHAVSVAVQAR
                     QLRVWPMLLRPLAHWFQPQGRKLRDQVRRARKIIDPEIQRRRAEKAACVAKGVQPPQYV
                     DTMQWFEDTADGRWYDVAGAQLAMDFAGIYASTDLFVGALVDIARHPDLIQPLRQEIRT
                     VIGEGGWTPASLFKLKLLDSCMKETQRIKPVECATMRSTALRDITLSNGLFIPKGELAA
                     VAADRMNNPDVWENPENYDPYRFMRMREDPDKAFTAQLENTNGDHIGFGWNPRACPGRF
                     FASKEIKILLAHILIQYDVKPVPGDDDKYYRHAFSVRMHPTTKLMVRRRNEDIPLPHDR
                     C"
     mRNA            complement(join(18178..24246,24313..24901,24960..25470,
                     25539..25872,25927..25984,26039..26125,26229..26542))
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcB"
                     /product="polyketide synthase"
     gene            complement(18178..26542)
                     /gene="mlcB"
     CDS             complement(join(18389..24246,24313..24901,24960..25470,
                     25539..25872,25927..25984,26039..26125,26229..26483))
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (31-451). E-value:
                     2e-174. Score: 572.3. Matches aSDomain:
                     nrpspksdomains_mlcB_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (567-894). E-value: 3e-90. Score:
                     294.4. Matches aSDomain: nrpspksdomains_mlcB_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (965-1148). E-value: 2.9e-28.
                     Score: 91.1. Matches aSDomain:
                     nrpspksdomains_mlcB_PKS_DH.1"
                     /NRPS_PKS="Domain: cMT (1426-1649). E-value: 1.5e-124.
                     Score: 407.6. Matches aSDomain: nrpspksdomains_mlcB_cMT.1"
                     /NRPS_PKS="Domain: PKS_ER (1859-2177). E-value: 4.2e-112.
                     Score: 366.1. Matches aSDomain:
                     nrpspksdomains_mlcB_PKS_ER.1"
                     /NRPS_PKS="Domain: PKS_KR (2200-2373). E-value: 1.3e-54.
                     Score: 176.7. Matches aSDomain:
                     nrpspksdomains_mlcB_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (2488-2560). E-value: 5.3e-12.
                     Score: 37.8. Matches aSDomain:
                     nrpspksdomains_mlcB_PKS_PP.1"
                     /codon_start=1
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcB"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 230.8; E-value:
                     4.8e-70)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="BAC20566.1"
                     /sec_met_domain="PP-binding (E-value: 3.5e-10, bitscore:
                     29.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 4.8e-91, bitscore: 294.4,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.6e-175, bitscore:
                     573.1, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 3e-50, bitscore:
                     159.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.9e-18, bitscore:
                     54.7, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MNNTPAVTATATATATATAMAGSACSNTSTPIAIVGMGCRFAGDA
                     TSPQKLWEMVERGGSAWSKVPSSRFNVRGVYHPNGERVGSTHVKGGHFIDEDPALFDAA
                     FFNMTTEVASCMDPQYRLMLEVVYESLESAGITIDGMAGSNTSVFGGVMYHDYQDSLNR
                     DPETVPRYFITGNSGTMLSNRISHFYDLRGPSVTVDTACSTTLTALHLACQSLRTGESD
                     TAIVIGANLLLNPDVFVTMSNLGFLSPDGISYSFDPRANGYGRGEGIAALVIKALPNAL
                     RDQDPIRAVIRETALNQDGKTPAITAPSDVAQKSLIQECYDKAGLDMSLTSYVEAHGTG
                     TPTGDPLEISAISAAFKGHPLHLGSVKANIGHTEAASGLASIIKVALALEKGLIPPNAR
                     FLQKNSKLMLDQKNIKIPMSAQDWPVKDGTRRASVNNFGFGGSNAHVILESYDRASLAL
                     PEDQVHVNGNSEHGRVEDGSKQSRIYVVRAKDEQACRRTIASLRDYIKSVADIDGEPFL
                     ASLAYTLGSRRSILPWTSVYVADSLGGLVSALSDESNQPKRANEKVRLGFVFTGQGAQW
                     HAMGRELVNTFPVFKQAILECDGYIKQLGASWNFMEELHRDELTTRVNDAEYSLPLSTA
                     IQIALVRLLWSWGIRPTGITSHSSGEAAAAYAAGALSARSAIGITYIRGVLTTKPKPAL
                     AAKGGMMAVGLGRSETNVYISRLNQEDGCVVVGCINSQCSVTVSGDLGAIEKLEKLLHA
                     DGIFTRKLKVTEAFHSSHMRPMADAFGASLRDLFNSDNNNDNPNADTSKGVLYSSPKTG
                     SRMTDLKLLLDPTHWMDSMLQPVEFESSLREMCFDPNTKEKAVDVIIEIGPHGALGGPI
                     NQVMQDLGLKGTDINYLSCLSRGRSSLETMYRAATELISKGYGLKMDAINFPHGRKEPR
                     VKVLSDLPAYPWNHQTRYWREPRGSRESKQRTHPPHTLIGSRESLSPQFAPKWKHVLRL
                     SDIPWIRDHVVGSSIIFPGAGFISMAIEGFSQVCPPVAGASINYNLRDVELAQALIIPA
                     DAEAEVDLRLTIRSCEERSLGTKNWHQFSVHSISGENNTWTEHCTGLIRSESERSHLDC
                     STVEASRRLNLGSDNRSIDPNDLWESLHANGICHGPIFQNIQRIQNNGQGSFCRFSIAD
                     TASAMPHSYENRHIVHPTTLDSVIQAAYTVLPYAGTRMKTAMVPRRLRNVKISSSLADL
                     EAGDALDAQASIKDRNSQSFSTDLAVFDDYDSGSSPSDGIPVIEIEGLVFQSVGSSFSD
                     QKSDSNDTENACSSWVWAPDISLGDSTWLKEKLSTEAETKETELMMDLRRCTINFIQEA
                     VTDLTNSDIQHLDGHLQKYFDWMNVQLDLARQNKLSPASCDWLSDDAEQKKCLQARVAG
                     ESVNGEMISRLGPQLIAMLRRETEPLELMMQDQLLSRYYVNAIKWSRSNAQASELIRLC
                     AHKNPRSRILEIGGGTGGCTKLIVNALGNTKPIDRYDFTDVSAGFFESAREQFADWQDV
                     MTFKKLDIESDPEQQGFECATYDVVVACQVLHATRCMKRTLSNVRKLLKPGGNLILVET
                     TRDQLDLFFTFGLLPGWWLSEEPERKSTPSLTTDLWNTMLDTSGFNGVELEVRDCEDDE
                     FYMISTMLSTARKENTTPDTVAESEVLLLHGALRPPSSWLESLQAAICEKTSSSPSINA
                     LGEVDTTGRTCIFLGEMESSLLGEVGSETFKSITAMLNNCNALLWVSRGAAMSSEDPWK
                     ALHIGLLRTIRNENNGKEYVSLDLDPSRNAYTHESLYAICNIFNGRLGDLSEDKEFEFA
                     ERNGVIHVPRLFNDPHWKDQEAVEVTLQPFEQPGRRLRMEVETPGLLDSLQFRDDEGRE
                     GKDLPDDWVEIEPKAFGLNFRDVMVAMGQLEANRVMGFECAGVITKLGGAAAASQGLRL
                     GDRVCALLKGHWATRTQTPYTNVVRIPDEMGFPEAASVPLAFTTAYIALYTTAKLRRGE
                     RVLIHSGAGGVGQAAIILSQLAGAEVFVTAGTQAKRDFVGDKFGINPDHIFSSRNDLFV
                     DGIKAYTGGLGVHVVLNSLAGQLLQASFDCMAEFGRFVEIGKKDLEQNSRLDMLPFTRD
                     VSFTSIDLLSWQRAKSEEVSEALNHVTKLLETKAIGLIGPIQQHSLSNIEKAFRTMQSG
                     QHVGKVVVNVSGDELVPVGDGGFSLKLKPDSSYLVAGGLGGIGKQICQWLVDHGAKHLI
                     ILSRSAKASPFITSLQNQQCAVYLHACDISDQDQVTKVLRLCEEAHAPPIRGIIQGAMV
                     LKDALLSRMTLDEFNAATRPKVQGSWYLHKIAQDVDFFVMLSSLVGVMGGAGQANYAAA
                     GAFQDALAHHRRAHGMPAVTIDLGMVKSVGYVAETGRGVADRLARIGYKPMHEKDVMDV
                     LEKAILCSSPQFPSPPAAVVTGINTSPGAHWTEANWIQEQRFVGLKYRQVLHADQSFVS
                     SHKKGPDGVRAQLSRVTSHDEAISIVLKAMTEKLMRMFGLAEDDMSSSKNLAGVGVDSL
                     VAIELRNWITSEIHVDVSIFELMNGNTIAGLVELVVAKCS"
     aSDomain        complement(18401..18616)
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_PP.1"
                     /evalue="5.30E-12"
                     /label="mlcB_PKS_PP.1"
                     /locus_tag="mlcB"
                     /protein_end="2560"
                     /protein_start="2488"
                     /score="37.8"
                     /tool="antismash"
                     /translation="IVLKAMTEKLMRMFGLAEDDMSSSKNLAGVGVDSLVAIELRNWIT
                     SEIHVDVSIFELMNGNTIAGLVELVVA"
     aSModule        18401..26390
                     /complete
                     /domains="nrpspksdomains_mlcB_PKS_KS.1"
                     /domains="nrpspksdomains_mlcB_PKS_AT.1"
                     /domains="nrpspksdomains_mlcB_PKS_DH.1"
                     /domains="nrpspksdomains_mlcB_cMT.1"
                     /domains="nrpspksdomains_mlcB_PKS_ER.1"
                     /domains="nrpspksdomains_mlcB_PKS_KR.1"
                     /domains="nrpspksdomains_mlcB_PKS_PP.1"
                     /iterative
                     /locus_tags="mlcB"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(18962..19480)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_KR.1"
                     /evalue="1.30E-54"
                     /label="mlcB_PKS_KR.1"
                     /locus_tag="mlcB"
                     /protein_end="2373"
                     /protein_start="2200"
                     /score="176.7"
                     /tool="antismash"
                     /translation="SYLVAGGLGGIGKQICQWLVDHGAKHLIILSRSAKASPFITSLQN
                     QQCAVYLHACDISDQDQVTKVLRLCEEAHAPPIRGIIQGAMVLKDALLSRMTLDEFNAA
                     TRPKVQGSWYLHKIAQDVDFFVMLSSLVGVMGGAGQANYAAAGAFQDALAHHRRAHGMP
                     AVTIDLGMVK"
     CDS_motif       complement(19007..19117)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0018"
                     /evalue="5.10E-21"
                     /label="PKSI-KR_m4"
                     /locus_tag="mlcB"
                     /protein_end="2358"
                     /protein_start="2321"
                     /score="67.3"
                     /tool="antismash"
                     /translation="VDFFVMLSSLVGVMGGAGQANYAAAGAFQDALAHHRR"
     CDS_motif       complement(19382..19480)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0017"
                     /evalue="1.20E-17"
                     /label="PKSI-KR_m1"
                     /locus_tag="mlcB"
                     /protein_end="2233"
                     /protein_start="2200"
                     /score="56.4"
                     /tool="antismash"
                     /translation="SYLVAGGLGGIGKQICQWLVDHGAKHLIILSRS"
     CDS_motif       complement(19550..19597)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0016"
                     /evalue="6.10E-07"
                     /label="PKSI-ER_m9"
                     /locus_tag="mlcB"
                     /protein_end="2177"
                     /protein_start="2161"
                     /score="22.1"
                     /tool="antismash"
                     /translation="AFRTMQSGQHVGKVVV"
     aSDomain        complement(19550..20503)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_ER.1"
                     /evalue="4.20E-112"
                     /label="mlcB_PKS_ER.1"
                     /locus_tag="mlcB"
                     /protein_end="2177"
                     /protein_start="1859"
                     /score="366.1"
                     /tool="antismash"
                     /translation="GLLDSLQFRDDEGREGKDLPDDWVEIEPKAFGLNFRDVMVAMGQL
                     EANRVMGFECAGVITKLGGAAAASQGLRLGDRVCALLKGHWATRTQTPYTNVVRIPDEM
                     GFPEAASVPLAFTTAYIALYTTAKLRRGERVLIHSGAGGVGQAAIILSQLAGAEVFVTA
                     GTQAKRDFVGDKFGINPDHIFSSRNDLFVDGIKAYTGGLGVHVVLNSLAGQLLQASFDC
                     MAEFGRFVEIGKKDLEQNSRLDMLPFTRDVSFTSIDLLSWQRAKSEEVSEALNHVTKLL
                     ETKAIGLIGPIQQHSLSNIEKAFRTMQSGQHVGKVVV"
     CDS_motif       complement(19796..19825)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0015"
                     /evalue="6.60E-03"
                     /label="PKSI-ER_m8"
                     /locus_tag="mlcB"
                     /protein_end="2095"
                     /protein_start="2085"
                     /score="9.9"
                     /tool="antismash"
                     /translation="GRFVEIGKKD"
     CDS_motif       complement(19871..19909)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0014"
                     /evalue="8.40E-03"
                     /label="PKSI-ER_m7"
                     /locus_tag="mlcB"
                     /protein_end="2070"
                     /protein_start="2057"
                     /score="9.1"
                     /tool="antismash"
                     /translation="TGGLGVHVVLNSL"
     CDS_motif       complement(19988..20038)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0013"
                     /evalue="2.60E-06"
                     /label="PKSI-ER_m6"
                     /locus_tag="mlcB"
                     /protein_end="2031"
                     /protein_start="2014"
                     /score="20.0"
                     /tool="antismash"
                     /translation="GAEVFVTAGTQAKRDFV"
     CDS_motif       complement(20051..20110)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0012"
                     /evalue="1.00E-09"
                     /label="PKSI-ER_m5"
                     /locus_tag="mlcB"
                     /protein_end="2010"
                     /protein_start="1990"
                     /score="30.6"
                     /tool="antismash"
                     /translation="GERVLIHSGAGGVGQAAIIL"
     CDS_motif       complement(20135..20179)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0011"
                     /evalue="1.40E-03"
                     /label="PKSI-ER_m4"
                     /locus_tag="mlcB"
                     /protein_end="1982"
                     /protein_start="1967"
                     /score="12.2"
                     /tool="antismash"
                     /translation="AASVPLAFTTAYIAL"
     CDS_motif       complement(20315..20353)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0010"
                     /evalue="8.70E-04"
                     /label="PKSI-ER_m2"
                     /locus_tag="mlcB"
                     /protein_end="1922"
                     /protein_start="1909"
                     /score="12.2"
                     /tool="antismash"
                     /translation="MGFECAGVITKLG"
     CDS_motif       complement(20375..20410)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0009"
                     /evalue="4.00E-05"
                     /label="PKSI-ER_m1"
                     /locus_tag="mlcB"
                     /protein_end="1902"
                     /protein_start="1890"
                     /score="16.3"
                     /tool="antismash"
                     /translation="GLNFRDVMVAMG"
     aSDomain        complement(21134..21802)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_cMT.1"
                     /domain_subtype="cMT"
                     /evalue="1.50E-124"
                     /label="mlcB_cMT.1"
                     /locus_tag="mlcB"
                     /protein_end="1649"
                     /protein_start="1426"
                     /score="407.6"
                     /tool="antismash"
                     /translation="PLELMMQDQLLSRYYVNAIKWSRSNAQASELIRLCAHKNPRSRIL
                     EIGGGTGGCTKLIVNALGNTKPIDRYDFTDVSAGFFESAREQFADWQDVMTFKKLDIES
                     DPEQQGFECATYDVVVACQVLHATRCMKRTLSNVRKLLKPGGNLILVETTRDQLDLFFT
                     FGLLPGWWLSEEPERKSTPSLTTDLWNTMLDTSGFNGVELEVRDCEDDEFYMISTMLST
                     A"
     aSDomain        complement(22637..23185)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_DH.1"
                     /evalue="2.90E-28"
                     /label="mlcB_PKS_DH.1"
                     /locus_tag="mlcB"
                     /protein_end="1148"
                     /protein_start="965"
                     /score="91.1"
                     /tool="antismash"
                     /translation="HTLIGSRESLSPQFAPKWKHVLRLSDIPWIRDHVVGSSIIFPGAG
                     FISMAIEGFSQVCPPVAGASINYNLRDVELAQALIIPADAEAEVDLRLTIRSCEERSLG
                     TKNWHQFSVHSISGENNTWTEHCTGLIRSESERSHLDCSTVEASRRLNLGSDNRSIDPN
                     DLWESLHANGICHGPIFQNI"
     CDS_motif       complement(23027..23101)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0008"
                     /evalue="4.30E-11"
                     /label="PKSI-DH_m2"
                     /locus_tag="mlcB"
                     /protein_end="1018"
                     /protein_start="993"
                     /score="35.2"
                     /tool="antismash"
                     /translation="WIRDHVVGSSIIFPGAGFISMAIEG"
     aSDomain        complement(join(23399..24246,24313..24445))
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_AT.1"
                     /evalue="3.00E-90"
                     /label="mlcB_PKS_AT.1"
                     /locus_tag="mlcB"
                     /protein_end="894"
                     /protein_start="567"
                     /score="294.4"
                     /tool="antismash"
                     /translation="VFTGQGAQWHAMGRELVNTFPVFKQAILECDGYIKQLGASWNFME
                     ELHRDELTTRVNDAEYSLPLSTAIQIALVRLLWSWGIRPTGITSHSSGEAAAAYAAGAL
                     SARSAIGITYIRGVLTTKPKPALAAKGGMMAVGLGRSETNVYISRLNQEDGCVVVGCIN
                     SQCSVTVSGDLGAIEKLEKLLHADGIFTRKLKVTEAFHSSHMRPMADAFGASLRDLFNS
                     DNNNDNPNADTSKGVLYSSPKTGSRMTDLKLLLDPTHWMDSMLQPVEFESSLREMCFDP
                     NTKEKAVDVIIEIGPHGALGGPINQVMQDLGLKGTDINYLSCLSRG"
     CDS_motif       complement(23504..23533)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0007"
                     /evalue="1.80E+01"
                     /label="PKSI-ER_m7"
                     /locus_tag="mlcB"
                     /protein_end="859"
                     /protein_start="849"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="TKEKAVDVII"
     CDS_motif       complement(24035..24139)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0006"
                     /evalue="8.50E-07"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="mlcB"
                     /protein_end="682"
                     /protein_start="647"
                     /score="21.7"
                     /tool="antismash"
                     /translation="GIRPTGITSHSSGEAAAAYAAGALSARSAIGITYI"
     CDS_motif       complement(24398..24448)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0005"
                     /evalue="3.50E-06"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="mlcB"
                     /protein_end="583"
                     /protein_start="566"
                     /score="19.3"
                     /tool="antismash"
                     /translation="FVFTGQGAQWHAMGREL"
     aSDomain        complement(join(24794..24901,24960..25470,25539..25872,
                     25927..25984,26039..26125,26229..26390))
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_mlcB_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="2.00E-174"
                     /label="mlcB_PKS_KS.1"
                     /locus_tag="mlcB"
                     /protein_end="451"
                     /protein_start="31"
                     /score="572.3"
                     /tool="antismash"
                     /translation="IAIVGMGCRFAGDATSPQKLWEMVERGGSAWSKVPSSRFNVRGVY
                     HPNGERVGSTHVKGGHFIDEDPALFDAAFFNMTTEVASCMDPQYRLMLEVVYESLESAG
                     ITIDGMAGSNTSVFGGVMYHDYQDSLNRDPETVPRYFITGNSGTMLSNRISHFYDLRGP
                     SVTVDTACSTTLTALHLACQSLRTGESDTAIVIGANLLLNPDVFVTMSNLGFLSPDGIS
                     YSFDPRANGYGRGEGIAALVIKALPNALRDQDPIRAVIRETALNQDGKTPAITAPSDVA
                     QKSLIQECYDKAGLDMSLTSYVEAHGTGTPTGDPLEISAISAAFKGHPLHLGSVKANIG
                     HTEAASGLASIIKVALALEKGLIPPNARFLQKNSKLMLDQKNIKIPMSAQDWPVKDGTR
                     RASVNNFGFGGSNAHVILESY"
     CDS_motif       complement(25071..25115)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0004"
                     /evalue="8.70E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="mlcB"
                     /protein_end="378"
                     /protein_start="363"
                     /score="11.8"
                     /tool="antismash"
                     /translation="GSVKANIGHTEAASG"
     CDS_motif       complement(25161..25208)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0003"
                     /evalue="8.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="mlcB"
                     /protein_end="348"
                     /protein_start="332"
                     /score="11.8"
                     /tool="antismash"
                     /translation="YVEAHGTGTPTGDPLE"
     CDS_motif       complement(25401..25439)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0002"
                     /evalue="2.20E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="mlcB"
                     /protein_end="268"
                     /protein_start="255"
                     /score="11.3"
                     /tool="antismash"
                     /translation="FDPRANGYGRGEG"
     CDS_motif       complement(25649..25696)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_mlcB_0001"
                     /evalue="2.40E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="mlcB"
                     /protein_end="208"
                     /protein_start="192"
                     /score="16.5"
                     /tool="antismash"
                     /translation="GPSVTVDTACSTTLTA"
     mRNA            complement(join(28093..31490,31541..32157))
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcD"
                     /product="HMG-CoA reductase"
     gene            complement(join(28093..31490,31541..32157))
                     /gene="mlcD"
     gene            join(28348..31490,31541..31919)
                     /gene="mlcD"
     CDS             join(28348..31490,31541..31919)
                     /codon_start=1
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1187:hydroxymethylglutaryl-CoA reductase (Score: 54.2;
                     E-value: 2.2e-16)"
                     /gene_kind="biosynthetic-additional"
                     /product="HMG-CoA reductase"
                     /protein_id="BAC20567.1"
                     /transl_table=1
                     /translation="MVASLLPSRFRGRESMNQQHPLRSGNRALTSTLQFLSKTACLHPI
                     HTVCTIAILASTTYVGLLKDSFFHGPANVDKAEWGSLVEGSRSLITGPQNGWKWQSFDG
                     DADVLGDFNHQALMTLVFPGSYGVASQAASPFLAPLPVNLSVIDLPSTSSPLTAYSKDK
                     VFAFSVEYSSAPELVAAVQEIPNNSADLKLQETQLIEMERQMWIMKAARAHTKRSLAQW
                     VHDTWTESLDLIKSAQTLDVVVMVLGYISMHLTFVSLFLSMKKLGSKVWLATSVLLSST
                     FAFLLGLDVAIRLGVPMSMRLLSEGLPFLVVIVGFEKSITLTRAVLSYAVQHRKPQKIQ
                     SDQGSVTAIAESTINYAVRSAIREKGYNIVCHYVVEILLLVIGAVLGIQGGLQHFCVLA
                     ALILFFDCLLLFTFYTAILSIKLEVNRLKRHINMRYALEDEGLSQRTAESVATSNDAQD
                     SARTYLFGNDMKGSSVPKFKFWMVVGFLIVNLVNIGSTLFQASSSGSLSSISSWTESLS
                     GSAIKPPLEPFKVAGSGLDELLFQARGRGQSTMVTVLAPIKYELEYPSIHRGTSQLHEY
                     GVGGKMVGSLLTSLEDPVLSKWVFVALALSVALNSYLFKAARLGIKDPNLPSHPVDPVE
                     LDQAESFNAAQNQTPQIQSSLQAPQTRVFTPTTTDSDSDASLVLIKASLKVTKRAEGKT
                     ATSELPVSRTQIELDNLLKQNTISELNDEDVVALSLRGKVPGYALEKSLKDCTRAVKVR
                     RSIISRTPATAELTSMLEHSKLPYENYAWERVLGACCENVIGYMPVPVGVAGPIVIDGK
                     SYFIPMATTEGVLVASASRGSKAINLGGGAVTVLTGDGMTRGPCVKFDVLERAGAAKIW
                     LDSDVGQTVMKEAFNSTSRFARLQSMRTTIAGTHLYIRFKTTTGDAMGMNMISKGVEHA
                     LNVMATEAGFSDMNIITLSGNYCTDKKPSALNWIDGRGKGIVAEAIIPANVVRDVLKSD
                     VDSMVQLNISKNLIGSAMAGSVGGFNAQAANLAAAIFIATGQDPAQVVESANCITLMNN
                     LRGSLQISVSMPSIEVGTLGGGTILEPQGAMLDMLGVRGSHPTTPGENARQLARIIGSA
                     VLAGELSLCAALAAGHLVKAHMAHNRSAPASSAPSRSVSPSGGTRTVPVPNNALRPSAA
                     ATDRARR"
     mRNA            complement(join(32417..32885,32988..33148,33267..33794,
                     33852..33923,33989..34012,34076..34302,34366..34442,
                     34501..34832))
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcE"
                     /product="efflux pump"
     gene            complement(32417..34832)
                     /gene="mlcE"
     CDS             complement(join(32499..32885,32988..33148,33267..33794,
                     33852..33923,33989..34012,34076..34302,34366..34442,
                     34501..34686))
                     /codon_start=1
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcE"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 363.2; E-value:
                     2.6e-110)"
                     /gene_kind="transport"
                     /product="efflux pump"
                     /protein_id="BAC20568.1"
                     /transl_table=1
                     /translation="MSEPLPPKEGEPRPQKEESQNDTLEATESKSQHITGLKLGLVVAS
                     VTFVAFLMLLDMSIIVTAIPHITSEFHSLNDVGWYGSAYLLANCALQPLAGKLYTLLGL
                     KYTFFAFLCIFELGSVLCGAARSSTMLIVGRAVAGMGGSGLVNGALTILSTAAPKHKQP
                     VLIGVMMGLSQIAIVCGPLLGGAFTQHATWRWCFYINLPIGAVAAFLLLVITIPDRISS
                     TDSELSTDKPMANIKSTLRKLDLVGFVVFAAFATMISLALEWGGSTYTWRSSVIIGLFC
                     GGGFALIAFVLWERHVGDAVAMIPGSVAGKRQVWCSCLFMGFFSGSLLVFSYYLPIYFQ
                     AVKDVSPTLSGVYMLPGILGQVIMAMVSGFAIGKTGYYLPWALGSAVLVAIGAGLVSTF
                     QPHTSTVKWVMYQFIAGFGRGCGMQTPIIAIQSTLSPEQGALGISLAVFGQTFGGSLFL
                     DFANLVFGSGLRTGLSKYAPTVDTQAVTAAGATGFRDVVSKNNLPGVVKAYSLAVDHTF
                     YLAVGATACTFVFAFGMGWRKIATKNDTRAVPETDA"
     mRNA            complement(join(36314..36527,36606..37069,37130..38030))
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcR"
                     /product="transcription factor"
     gene            complement(36314..38030)
                     /gene="mlcR"
     CDS             complement(join(36315..36527,36606..37069,37130..37832))
                     /codon_start=1
                     /function="involved in ML-236B biosynthesis"
                     /gene="mlcR"
                     /product="transcription factor"
                     /protein_id="BAC20569.1"
                     /transl_table=1
                     /translation="MSLPHATIPTNLRRRAFRRSCDRCHAQKLKCTGSNANLVRAQCQR
                     CQQAGLRCVYSERLPKRNLHKEAAAGTTRATETSQPMTATSSTVFSSLAETPPPYCSPP
                     THIGTSALKETLSEPSAATLQFYDTSINFDDPESFPGGWPQPNTFRDDANSNESSGIPD
                     LGYDFEGPLDATAPVSPSLFDLEVEGNSSSGQSNTSNTQRDLFESLSDVSQDLEVILHG
                     VTVEWPKQKILSYPIGDFLNAFGRLLLHLQERVITSSNSSMLDGCLQTKNLFMAVHCYM
                     LSVKIMTSLSQLLLSEVMKAQPCGQKQSTRMDWYWSGSTTRNDNGRAEALPSFHSNLHI
                     GELISHLDPFMHALSSACTTLRVSLRLLSEIETALGIAQEHGAAASIRLVLSDMPSTSW
                     QILGAENKTITPASRLLSVLWSDEAGDEEPKSTKASGKTINVLRRCYKEIFALAKKHNI
                     A"
ORIGIN
        1 ggatgactat tccagtgatt agcactggag gtatatagtt tcttccaggg ttccttttat
       61 gcctgcccaa agccagccct ggagtcaatt tgatgtacta accaggcatc aactttgtca
      121 acaagccctc gagcgctacg tatatatatt tatacccccg tggaccttga tagttgagcc
      181 aattgaatcg catcattcca aggttcttct cacttaacaa tgaaatatac atttccaatg
      241 tttccttcag cctgattact cctaaattat tctttcaagc gagctcgtgg tctcccgaat
      301 ggtggactgt actgaatagg catagaggcg tcaaactccc gacaccgaat aacaccgtga
      361 cgccgatctc gcagattcct tctgagtgtt taaaatatca gctgcaccat tccatttttg
      421 ataggcacgg caattatctc cgatcaccat actcagcgaa agatggcgcc cagcatagat
      481 gttattccca ctgctgcttc cacggcagca ggaatgattt cagacatgga agcggcattt
      541 aagtcggccg ttaaattaaa gcaaatcccc ggggccgttg tcatggccag gagcatgaac
      601 ggtacgtgat gttttctgga ctatcttgca catctcttgg cagaacaaca cattgacgac
      661 ttgtattctt aataggtgac attgattaca cgcggtgctt tggggcgaga acggttgagc
      721 gcgatgaatg ccaaagacta ccaccaatgg aaatcgacac acccttgcga cttgccagtg
      781 caacaaaact tctcaccaca ataatggcct tgcagtgtat ggaacaaggt ctggtggacc
      841 tcgatgagaa tgtcaacagg cttcttcccg atttgagcga catgcaagtc ttgactggct
      901 ttgacgcggc cggtaacgcc ataatgaggg atcgcgaagg gattatcaag ttgaggttcg
      961 tatcatgatg aagcgatgtt gcgccatgtc tattgattcc ttgttaacgt gtacattgcc
     1021 atggctctta aaggcacctc ttgactcaca cttcgggtct ctcttacgca ttcctacatc
     1081 ctctcctaca ggaatacatg gccaagggtt acctcaagac agccgagaaa ttcggcattc
     1141 aaagtcgact cgctcctcct gcaatcaacg accccggagt agagtggatc tatggtgcaa
     1201 atctcgactg ggccggtaag cttatcgagc gcgccaccgg tgtggacctg gaggaattca
     1261 tgcagaagaa tatttgcgag cctctaggta tcaccgatat gacattcaag ctgcagcagc
     1321 ggcctgacat gcttgctcgt cgttctgatc agacgcgccg taatgagaat gggagtctgc
     1381 gatacgacga ctcggtttat ttccgccatg acggggagga gtgcttcggg ggacagggcg
     1441 ttttctgcgg cccggagtca tatatgaagg tccttaactc cttgatgaag catgacggtc
     1501 tcctcttgaa gaaagacaca attgagctta tgttccagcc cgctctggac gcggagctcg
     1561 aaaagaaaat gaatgatcac atggatacca cgccgcacat caactacggc gcagcattgc
     1621 ccccggttat gaggagaaac tttgggcttg gtggaattat cgctatgggc gatctcgatg
     1681 gtcataattg gcggcgggag gggtccctca cctttggtgg cggaccgaat attgtttggg
     1741 tgcgtatttt gattgattta actgcaatct ttggcaggtt cacagacata tattaacgca
     1801 tatatagcaa atcgatccga cggtagggct ttgtaccctg gttgttttcc agctagagcc
     1861 ctggaatgat ccgatttgca aagatctcac tcgcaagttc gaaaaagcga tgtactcaca
     1921 ggtgaaatgc cgcaactagt tagagactag gtacatgaga cccatgtaaa tgatttacaa
     1981 gtattcaagt ccaattttta taattagtct actactttgc gcatagcaaa ttcaacgcca
     2041 cagcgctgga gaataccatg acgcctacct aggtagtcac tgtgttgagc tggcccgata
     2101 aatctcatca gaaatggtgc attatgtctg tgcggtattt gaatgtttgt ggaacaggat
     2161 cattgatctc tcgctctcgc tctcgatgga tcaatatagc tgccagtatt gataaacaac
     2221 taaccctcta gcccagatag agaaaagaaa aaaaaaaaaa aaaaaaagaa gagagatagt
     2281 ggatggacaa accagggtca agtaatcatg tacaatcgcc taaccgggta tcaacgctct
     2341 caacacacac atgtcatggt cactgggcat tcatttattc tatatttgat tgcaagtatt
     2401 aaacttaaac ggaaaaccga accacaatct tctctcccga cagctctcca ttcctaacag
     2461 tctccatacc ctgcttgacc tgctccagcc caccatcaat gacacgcaag gggtgatgat
     2521 acagcttgtc ctcctcgaca agccttgagg cgacttgcca gagttcggtg ccgaaaagac
     2581 gcacctcttc gctcgcctca cagccgtacg gtgcaggcca agttgagccc tcgccgaaga
     2641 tagtcggacc gagggtccag tccgaagtga ccatcttgcg tgtggccgcg tgctcgggga
     2701 aggggttcag cgcgacgtat cgtccgccgg cacgacctat tgctttgtag cacgtcgatg
     2761 tggactcaac gttaatgatg cagtccaagg cataagcgag attgtttctg gtgtaatcac
     2821 gctacgaata tataggatta attgggagtg caatcaagca atgttattga tgtgaagggg
     2881 gtttatgttt gtgcaggggt taaaacaaac caaggaaaag actcacaatt ttttgtgcac
     2941 aatctgcgtc gcggtagtcg aatacctctt ctgcgccatt cttcttggca agatcgaagt
     3001 tcttatgaga acaggtagcg atcggtgtgt atccagacct atgaattcaa ggtcagacct
     3061 gacactgaat caaacgaata atttttgcaa aatcgaaaac ccatacaatc tcataaactg
     3121 cattgcaatg gtggccgtag cagtgctgcc accataaatc aggacgtaag tctttttgct
     3181 aggcttagtc tcgctgtacg gcaatggcat accgagcagc ttcatagcca agccagtggt
     3241 actaataccg gcaggaagcg acgccgcggc ttcccaggtc atcgaatctg ggattttggc
     3301 ccagatgcga ccgcgggtga ttgtgtactg cgaaaaggcg ccctgttcag gcgtccgcgg
     3361 acacatctcg ttctgagccc caaaaacacg gtctcccacc ttgacatggg tgatttcgga
     3421 tcccacagca acaacagtgc cggcatagtc agtacctaga caggcaaatg gcgtggcaaa
     3481 gtcgcctcgc atcttagtgt cactgggatt gacagcgacg gcatggatgc ggacgtagac
     3541 ctggtccgcg ggcagcttcg gagtcggggc gtcatcccag atcaccacct cgtctttgtc
     3601 gtttactgtg aggattgtct gtttcaccgg tgggatgaaa ctcccttcag tcatggcaac
     3661 gcccattgtg tgtgtggtgt taggttcgat tgatgtgaat cagcttgatg cgtcaaggct
     3721 gcctgtgatt gaataaatac aaagaatgct ttttaatatc tttatcctaa tatgcaagat
     3781 acctataggt cttttgctta cgacttgctg cccccaacat ttcgggcggc tcttcgtgcg
     3841 gcgccatcgg gatacggcgt tgttcggcgt tagcaaaatg ccgatagttt caaaagtctt
     3901 catgcactcc cacggaggca agttggcttt gtcgactgat ttcggttacc aagcacagga
     3961 atcacagcag aacagtcatc tcagattagg cgtattggtg tggttcatcc cctttggttg
     4021 ccaggtagga tcaatactac gtcgttgtta tttccttgtc agtaatgact aacaaattcc
     4081 ccagaacaga cgaagtcaca gctcacacca caagagaaaa tgagtccagc gaggattaca
     4141 gatttctcgc caggcaaacc gagaaaagct ctcttatgca tccacggtgc cgggtgctca
     4201 gcagccatat tccgcgtcca gatctctaaa ctgcgcgtgg cgttgaaaaa cgagtttgaa
     4261 ttcgtatatg cgaccgcgcc gtttagctcc agccccggac ccggcgtgct tcctgtcttc
     4321 caaggcatgg gtccatacta cacctggttc caaaagcatc atgacgccgt tacaaacacg
     4381 acaaccccca cggtgggcga tagagtagcg gctgtgatcg ggcctgtgca aaagaccgtc
     4441 caagattggt ctataactaa cccacaggca cccattgtcg gcatagtggc cttctctgag
     4501 ggcgcattgg tcgccacttt gctgctccat caacagcaaa tgggaaaact gccatggttt
     4561 ccgaaaatga gcattgctgt tttgatttgc tgtttctata gcgatgaagc cagagattac
     4621 atgagagccg aggcgcaaga cgacgacgac aagctaataa tcaacgtgcc gacactgcat
     4681 cttcacggtc gtcaagattt tgctctccaa gggtcgagac agatggttga aacacattac
     4741 ctgcctcaga atgcagatgt actcgagttt cagggaaagc ataattttcc caacagaccg
     4801 agtgatgtcc aggagacggt caagcgcttc caacagctat atcaaaaggt caagatgtca
     4861 ggttcatttg tctaggtgag acaacagggt atatagcaag gctctggctc tcatgcctag
     4921 tccataccac atttttactg aacaaatttg aatagttcta atcttacacg gtttgaatgc
     4981 tcaccttcca agggtgattt agttatagtg gtcgcgacca tctcataaat atttcgtgaa
     5041 catattttgg atagatcatg gaaggctcgt tctgaacagg catgacagac atctaaaacc
     5101 actcgatcac cacaacaagg cactaaacca gtaactatgg aactatttgc aatggcgtcg
     5161 aatttatata caggatggat tgaaatcaat tccaagcctt ggaggtttca ccttcctcac
     5221 agagtctttc gaaacgcgct accgaggtat atttatcacc gttacggtac tctgaaccgc
     5281 gctatctaac ttgatgttac gattgctgca ataaagaaga gcaacgaagg tagaagtaat
     5341 tttgacaaag atacaagacg aattcgctat ttgtagatga atatgcgtgt gtcaattgag
     5401 ccgaattcag gatagatttg ccatctgctc tattgccaat ttctaatcca tctttatcat
     5461 gaacaacact caaaccacac atctgaattc acggcgctga acgatctagg ccaacttcag
     5521 agccgggttc atcgagaaca tagtgaggat tgaagaaaag tggtctacaa aggcctgagc
     5581 gtgctcaggg ccatacagcg agctctgaag tttgacatga atgagtgggt ccttggtagg
     5641 gtcatcccac atctcgagaa cgatgtcata aggagtgcgc tcacgggaag cgagaacact
     5701 cgtcattttg gcattgccaa ttgagccact ctccgcttga ccctgcttgt aatcaaagac
     5761 agcctggaac aagggggcgt gtgtctgagt cttgggttcc tcgcctgagg tagggagatt
     5821 caggcctaga cagtcgagga tgacgccata cggcacccgc gcgtgttgca tggcctcacg
     5881 cacactgtcc ttggtggcta caaggtgctc gccgaatgtc ttgctgccga cgaactcatc
     5941 aaagcgcagg ggaagcacgt tagcgaaaaa gcccatcgcc gaaatttctt ccatggtgga
     6001 tcggttggtt tcggcgaggc cgatggttat gtctttgctg ccggtaagac gcgccaacaa
     6061 aacgtggtag gcggccaggt agaactgcat gggggttgcc ttgtgcttgc ggctccgctc
     6121 tttgattcgg aaggcgacca tgggatctaa acgagcaatt gcttcatact gctgccacgt
     6181 gaatggctgt atttgctgct gctctgaatt ggcagcaggg tcattgatca gattcatgat
     6241 gggaagcacg gttggcgcag atgacgagac tttgctatgc atggacttcc agaacgcgat
     6301 atcgtccccc attcgcccat tttccaggtt ttcccgctgt tggacggcta gatcagagaa
     6361 ttgggtcgat ggtcgctgca ttttcacccc gctgtaaatc tgcccgatct cattgaacag
     6421 gttttctgtt gttgagccat caccaactaa tctgtggtag ccgattacca acaggtggtc
     6481 atctgtgccc cagtagaaat caacgagtct gagagtgtca cctgtggaga tgctatagtt
     6541 tgtcttctcg agtttccggt actcttcctc tgcctccgca gcgttgttca cctgaacaaa
     6601 gtgcactctg ttctccgggt tcttgagaac cacttggacg ggaccattta aatcgctgct
     6661 atagtcatcg ccagtaacaa agcacgtacg gaagatctcg tgacggcgca atgaggcttt
     6721 cagagcccgc ctcaaccggt cgaggtcaat ggtacccttc atgaacatgc caatagtgtt
     6781 gttgaagatg gtatgatctt ttaccatttg ttgctgcctc caggaatact cctggccaag
     6841 ggacaacctc tcgcgacgaa gaatcttacg gcctccctgc tcattatcgt cctcttgctc
     6901 ttcatcctct tcggctgacg acgcatctgt gctggtagca gagcttgctt catcatggct
     6961 gtctgttggt gtcggagaag ccccgctgtc cgaggttccc gtggaatcac caatttgcaa
     7021 cagcagcgga atggatgtag ctgggagtcg ggtggccgcg tcgtcggcaa gatcagcgac
     7081 agaagcaccg ccaagtaccc tcaagagtgg gaggtcaagg tagagttgct ttgagaacca
     7141 tgagccgaca gtcactgcac ccaaggagtc gacaccttga tcaatgagag gaatggttgg
     7201 gtccacgctc tccccgtccg aaacttggag ggtaacacgg agtttctcag atagaccatc
     7261 tgcaactttg ttagtttgaa ctcgatatca ggaaacgcat gagagataac ttaccaatca
     7321 cgatttgccg aacttggtct aaagttgttg cttgtttgag ctggtcggca atggagcctt
     7381 tagaccctga tccattgtcg ccaccgtctc cgcgttgacc gggaattttg aagtttccga
     7441 aacgagggtc gttgaagtaa ataattcgat cttgaagcgc agggtcaaga tctgggatac
     7501 ccgtggtaag ctcaaggtcc gccatgtcaa tgaccgtctt gcgctgtggt tgctgccggg
     7561 cacgctggtc agacacgacc gcttcggcga aaagcgtgtg cagctcatgc tcttcaactg
     7621 agtcaaacat gaaacggata gcatcaaagt cctcctccat ctcggccctc gtgacaaacc
     7681 ctacaccgta aacggcacca atatcgatgg ttgatccctg tggttgtgcg ttagtaactt
     7741 gacgtcgatg catgataatt caggggtaga aaataccgcc aatcctctgg cgcaccgttg
     7801 ctgggccaga gcctgtaggt aggcattcgc agcgccatag ttggactggc caggattgcc
     7861 aataactgca acaatggacg aaaacatgat gaagaagtcg agcgccttgc tgcccgtctg
     7921 ttcggagaac cgttcatgaa gaatgcgtgc tccttgtacc ttgggcttca acaccatgtc
     7981 catcatctgg tggtccatgt tcttcagcat gacatcctgc agcaccaaag gcccgaacgc
     8041 gatgccggca acaggtggca acttcatatc gacaagcttg ccaaggccag catcgactga
     8101 atcctcattg gcaacatccc taaagaaagt aattggataa gtaaacgagg atgtggtagc
     8161 aaggtgtgat gtgatatcaa tcaacttaca ttgacagaac ggtgatgtca ccaccaagtg
     8221 cctccatgtt ggcgatccat ttgggatcaa gtcgagggtt ccggctagtg agcacaacat
     8281 ggcgggcgcc atgcaagatc atccagcgac agagagagcg accaaggtcc ccggtaagac
     8341 caacaagcaa atacgtcttc ttgttggaaa ataagttacc agagtcgatg gggcaaatcc
     8401 tagcggacac ctcattttcc ttccagtcga tgacggtggc cagattgaag cgttggtcat
     8461 tgtggttgac agagagctga ccaggcaaga gaatttgtgt ggctgtaata actttctcag
     8521 tgtcgtcgac agtcgacgca gagacggtat tttttgccat tgccacagag tgctcgagga
     8581 ttggaatatc ctcaacatga ctaactttgt atgtggaagc tgtacttcgg ataagatagt
     8641 caccactgta catgaagcaa ctgggtggta gcaacttggc caaacggttg gttatcccgg
     8701 cagcagtccg gtcggtagac aagtcaaaga atgccatcat gtttgtcggc aggctgtgtt
     8761 tcagccgagc gtcggtttcc ttggcatgta atcggatcca aggagccgga atagttttga
     8821 cgtcggacag agttgttgcc aaatgaacct gaacaccgta ggttttggcc gactccagaa
     8881 ttgctttgac gcagaagatt gggggctcca taatcagaat tgatgcatca gagccaaagg
     8941 actgagcgct agagagaatt gtttcggcaa ggagggctgc agctgtggac aacaagaagg
     9001 aactatcctc gccttccgcc atgttatcgg gcagactatg catgtagttt ctcggtacat
     9061 gcagtataga tccattcttc tcagccaggg cgactacagg cacctcacat gtattctcca
     9121 gaatactgcc ctgcacgaca tggaagtatc cgagatggcc cacgcgaatt gcctggggaa
     9181 gagcgtagcg aacacgaaca gttgcttttc cagcatgacg agcgtcttct aacgaatcac
     9241 acgtctcggt tgactcaaga tagtacatcg atgaggatgc tcccctcgcc tctttcagtg
     9301 caatggccgt cttggacgaa ttaaagttac cgaaaattgg acgacgagac gagttcatac
     9361 ggtcgttcct agcaatatcc tgcttcaaac gagggaccca ggcacgaccc ttgcaccagt
     9421 acacttcggg ctcatgagtc catgttattg attccaaaag ctgatcatcg ctctcctcga
     9481 agcgcaaaag ttgctcaacg aagaatttgg tgtctaggtt ctccacagta tcgacatcga
     9541 agacgtgcgt tcccaagtca gggttctcga gcttgattgt cctcaacatt ccgatggtgc
     9601 tggcctggtg gggatgatca atccaggcat tctctgtcag ccacatcatg cgtccggcgt
     9661 agaagagaag agacttgact gcctcaaact tgtcctcttc aaggttgcaa aacacttcat
     9721 catcaagttc cgagaggatg acaaaagtcg acttaggctg caaggccggg tcgtcgagaa
     9781 cactttccag ccgcttgacg gagtggatgt gtctatgcgg tagggcagct ttcatgtcgt
     9841 tcaaaatgcg ttcggttttt gtcgattcgc caccgataac cactaatggc gggtatgagt
     9901 ccttcaatgg agcagaaagt ggatcataca aacgctcaac ggtggcatcc acagcatgtg
     9961 tactgaagac agacgggatc aaatcatcct ctcgatcaag tgtccgacta tcgacgccag
    10021 agaacccaac tctcttgagg gtatgctccc attggtcaac ggaccccgag gcactcaaag
    10081 cacgagtttc gtcttctcca gtccatcgat cagcgaaaag cccagagatg aaggcgaggc
    10141 gagcaggctc gcgatgggtg accccgaaag taaccaagtg accacccggc ttgagcaagg
    10201 accttatgtg agccaatttt tcctcgaagt tggagctggc atggaggaca tcggatgcaa
    10261 taatcagatc gtaggagtga ggcttgaatc cttgctctgc tgggcttctg ttgatgtcta
    10321 gtgcctcaaa ctgcatgaga ccgtcgaatt cggaaagttg ttcacgggcc ttgccaataa
    10381 catccgccga gatgtcagtg caagtgtaac tgttgaaacc aagttgaggt gatgcaagaa
    10441 cgcgcttcgt ggcgatgcct gtacccaagc ctaaaaagcg aacgacagat tagcaaactg
    10501 cctagttact tacatttcag attcgactta ccgatctcaa ggatatcaat ggattggtag
    10561 cgatgagcaa tttggctaac cagatcctga acgacgtgta ttgctgagcc aaaggcgagc
    10621 ttgttggtat agtactcggt gaacaaccca tcgcggttca tgatatccaa aggatccccg
    10681 ttcccgcgaa caattgaaat taattctttg cctacccttt ggatcaggcg cacatgtggg
    10741 tgggacgagt tgcttcaagt aaaaggttaa tataaaagaa tgaaaaaaca cggaacagct
    10801 ttgggtgtac ctttcacaca tttgctcaat gtgaacagaa gtgtcctcct cccaagactc
    10861 ctggtaccac tgatggtggc cagcccgagc atcggcctga acctggtcac accattcaat
    10921 gtacttctgg gaatggaggt cggcattttg acggtcgtcg ggggttatct gggctaggaa
    10981 ggatttgatg tagaagtaaa cgattcgctc gatggtcaga atgtcctcct tgtcccgagc
    11041 tatgatcaac gtcgcagggt cctccagcag tttttcgggc gtgaggggtc cccagaccca
    11101 ctttgcgaag attcggtggt cggtcgaagc agtcggggga gagaaaggct taaagacaat
    11161 gttatcaact tggaaaagcg ttgtcttggt cgaatcgtac accgtgatgt cgccgctcag
    11221 gaaatcaccc ttgtcgtgtg tgttgattgt gtcaaacgca agctcggttt caccagaatt
    11281 acccgccgat atacagagcg atggaatcag agtcactctg tcaacgtgag taggcacgta
    11341 caatgagcgt aggcgacgat ctcctggaga ggaatacgct ccaatgacag tctggaacgc
    11401 gatgtccagg ggcgctgggt ggagcaagag gggctcattg cgcaattcat ccttaagtgg
    11461 aaggaaagcc aaggtgccgc tagctttgga gtcggccctt ctcatggtct gcaaacgacg
    11521 gaagtctttg ctgtagtcat acccaaggag gtcaagttcc cgatagaaga aatcgatgtt
    11581 gacattgttc atctgggggt actcttcctc aggtggcggc aaaagctgcg atgacggtga
    11641 tgcctcgcca agggttatga cgatttggcc tttggcggat gtcgaaagct cactctcctt
    11701 tgccagacag gaatcaataa caaatttgac cgtgacttgg ccatccgcat cattgtcact
    11761 ggtgacttcg gctgtcaagt tcagctccac ggaggtgttt tcatcttcaa acacgatggc
    11821 tttgttgatg ctcatgtcca agatttccag gagctgaact tgggcggcac gctcaccagc
    11881 caccttcatg gcagcttcca tggccataat tatgtaccca gcagcgggga acacagtctg
    11941 gccttgtagc gcatgaccgt cgagccattc cagatcccgg ggcctgatga agtttgtcca
    12001 ctggaaggtc gatgctgtgc tgtaagaaga aagctttcca agcagaagat ggggcgcacc
    12061 tccacgaaga tgctggcggg tggagcgaga ttctgcccag tattgacgag tatgatccca
    12121 agagtatgtg ggcaatgact ttgacaggtt ttgaacggca cgatcgggcc ggacttgttg
    12181 tacgaagccc tcggcgtcga tactccgaac tccgaaacgc tcccaaatgt atcccagacc
    12241 tccagcaaaa gcgtccacat cgtcaacgtt tcgtgccaag cacccggtat acggcagctc
    12301 cacaccggca agagcatcct tgatggtggc tagacacgga cccttgagag cagggtgggc
    12361 gccaatttcg atggcgacgt cgattagacg atgagtgatg actgctttct gcacagcctg
    12421 cgagaacaag accggagaga cgagattgtc tttccaataa gcgggcatca catcctgtac
    12481 agtcatttgc ttgctggtct cgtggacggc agagaaccaa gcaacactat cgttaccttg
    12541 gccatcggca acagcacagt cgcactccag caatgccttg acatatggag ctgcgcatgg
    12601 gtgcatgtga tgcgaatggt aggccttgtc aactctcaag attctggcaa aagtggattc
    12661 atcctccaag acaccttcaa cgtgctggat agcatccatg tcgccggaga aggtcacact
    12721 atccggtgaa ttgctagcgg cgacgcagac ccgaccctca aaggcttcga gctcgcatag
    12781 ttcctttgcg tcatcgtacg acatacctgc cgctagcata gcgcctgtct ggccgcttgg
    12841 agaagaggca tgctccgcgg acacaactcc acgcagatgc gcaatacgga tagcttgagt
    12901 ggcactgatg aatcctgccg caaaggcaca ggcaatctca cctgaactgt ggccgacaat
    12961 tgcactgaac tcgataccag ctgcagcgag aagtcggacc agaacgattt gtacggcgca
    13021 gcatagaggc tgggagaagc tggcgagtct gacgtttgag gcatcccctt caagcatgag
    13081 ctggtcatac agtgtccacg taggccgata cttttcaggc agtgtttgca gtgaattatc
    13141 cagctcttcg agaatgcctc tcacaaatgg catacccacc atgagcttct tcagcatgcc
    13201 cggccactgt gcaccttggc cagtaaagac acctagtacg cgagggttgt cattcgcgtc
    13261 ggtgcggaag tcggtgacga cctcaccgtc cgcgatggca gcctccagtg ccgcgcgggc
    13321 tacttccttg ttgtgtgctg caatcgcacg acggaagggc aagatagacc gtttctcaag
    13381 taaggtatat gcgatatcat gcatgtccac gtcatcatgc gtttccagaa attggagcat
    13441 attttctagc gttgccttca tggagcgctg cgacttcgat gaaagcacaa ggggcaagct
    13501 gcatgcatct gcatctgagg tcacctctgt taccactgct gtcggcttgt gtggaggagc
    13561 catatactct tcgataatag catgggcatt tgtaccacca aatcctgatg tgtttatatg
    13621 tttagctaac ttcactttcg ttctcaagaa gtgcagttga atccttacca aatgaattaa
    13681 cgctgactct gcgaggctgc ccgggcgcaa caatcggcca ttctgtggcc tccgttgcaa
    13741 ttttcaagtg cgtatagaac ggagcgacac ggggactgat cttctcaaac agcaggtttg
    13801 gcgggatcac gccatttcgt acagcaaacg atgccttcat taagcccgca ataccagcag
    13861 tgccttccgt gtgaccgaga actgtcttga tgctgccgac aaaaagctca tctttctcgc
    13921 cgtcgctgtc gattgttcca tccttgtgtc cgaagaaggc tgttgcaata gcctcagctt
    13981 cctgtgggtc accggctggt gtaccagttc ctgggatctt cgtgttaggg agagagagac
    14041 tttctgcaac ttccataagg ctgatacttc cagggaatac cacttaccat gggcttcaaa
    14101 gaactggcag cgttcctggg ggttggtaat atcaagacca gccttggcat atgtggcccg
    14161 aatgagggct tcttgtgcgc tatggtttgg cattgtgata cctgtcgttc ggccatcttg
    14221 gttgataccg gtctctcgga taacacactc gatactgtcc ccgtcgcgca gtgcctggct
    14281 cagcgttttc aggacaatag agcaaacacc ttcctaaaaa gcagttacag gaggtcagtg
    14341 ccatcttgct ttttttgaaa ggaattgatg cattgtcaac ttactcctct ggcatatcca
    14401 tcggcagcag catcccacat tcgagatcta ccattggggg acagcatgtt caatttgctc
    14461 tccattacaa aggtcatggg gcccaatatc agattcgcac cggctgcaac cgccatggta
    14521 ctctcgcccg ttctaagctg ttggacggcc agatgcacgg cagctaagga tgaactacag
    14581 gctgtgtcga tcgtcatctg cagaatcagt caggaatctg tcagcacttg acgaagtcgg
    14641 gctcgctcaa tgagtggcac tcacactcgg cccatgccag tcgaagaagt atgatacacg
    14701 gttggaggcc acactgacag ctacccccgt ggcagagtat gtaggaatac tatccaattc
    14761 acgcgtcacg atagtctcat agtcatgcgt catcataccg acgtacacag cagtagagga
    14821 tccttgaagg ccttggatcc gtaggcctgc gttggataca gcttcataga ccgtctccag
    14881 cagcagcctt tgctgtgggt caatcgtttc ggcctctcca gcttggatgt tgaagaaaga
    14941 ggcatcaaaa ccgcgtagat cctcctgcag caagtatgca aagggtgcgt tcgtgcgccc
    15001 ggggtgagtg ccatcggggc tgtaaaatgt atcgacgtca aatctctcct tagggatctt
    15061 ggtctgtaca tcccggggct ctttgagcag ctcccaaagt tttgatggtg tgttgacacc
    15121 acctggaaac cgacaaccgc ttcccactac cacaattggc tcgtttggat agttggcttg
    15181 atccataact gctgatcctg tttttgggcg ataggattgg gattaaacct tgtcttgcgt
    15241 cagtagatct tctcactgca tgccgggcac aacatttgtt cttacagaat cgcagagttg
    15301 aatctctgag cgaacaagcc ggccttgcaa ccgataccgt cgttatattt acttgcacgt
    15361 atcagtactc atctagattc ggacaatttc aagatccatt ctagtactca aatgccccca
    15421 cttcccagca atgcaagctc ggcacctagc aaaccctccc ggcgtcattc ggtgcacgaa
    15481 tagccattcc tccatacggc gttattcggt cacacgaggc tgaatgaatc aaacgtgaat
    15541 atcaattggc tgtatcaagg tgaaaccgag tttttcactc ggattgttct tgtgctgctc
    15601 ggtgaagctg ctcctaaagg aaacaaccga actgccccat ccaggtaaac ttcgattggg
    15661 gggggggttt tttttttttc aaggttgact ggaagagtgc tctcggccac aaaatcccag
    15721 aagcattagt gctgttattc gattataaac cgtcgcagcg ctctcattct tcgctctttc
    15781 ttcttttcca ctggtgtgca taggtcctat ctgtctcacg caatgctcgg ccaggttctt
    15841 ctgaccgtcg aatcgtacca atgggtatcg acccctcaag cccttgtggc ggtcgcagtg
    15901 cttcttagtc tcatcgccta ccgtttgcgg gggcgccagt ccgaactgca agtctataat
    15961 cccaaaaaat ggtgggagtt gacgaccatg agggctaggc aggacttcga tacgtatggt
    16021 ccgagctgga tcgaagcttg gttctcgaaa aacgacaagc ccctgcgctt cattgttgat
    16081 tccggctatt gcaccatcct cccatcgtcc atggccgacg agtttcggaa aatcaaagat
    16141 atgtgcatgt acaagttttt ggcggatgta tgacctctga attttccatt gttgtaactc
    16201 aatgacgtct ctaagattct gatgaatgta taggactttc actctcatct ccctggattc
    16261 gacgggttca aggaaatctg ccaggatgca catcttgtca acaaagttgt tttgaaccag
    16321 ttacaaaccc aagcccccaa gtacacaaag ccattggcta ccttggccga cgctactatt
    16381 gccaagttgt tcggtaaaag cgagggtaag tgtcaatttt tctgtcttga gcattgagcc
    16441 tctggctgac ataccgcgaa tatactagag tggcaaaccg cacctgtcta ttccaatgga
    16501 ttggaccttg tcacacgaac agtcacactc attatggtcg gcgacaaaat ctgccacaat
    16561 gaggagtggc tggatattgc aaagaaccat gccgtgagtg tggcggtaca agctcgccaa
    16621 cttcgcgtat ggcccatgct actgcgaccg ctcgctcact ggtttcaacc gcaaggacgc
    16681 aaattgcgtg accaagtgcg ccgcgcacga aagatcattg atcctgagat tcagcgacga
    16741 cgtgctgaaa aggccgcatg tgtagcgaag ggcgtgcagc cgccccagta cgtcgatacc
    16801 atgcaatggt ttgaagacac cgccgacggc cgctggtacg atgtggcggg tgctcagctc
    16861 gctatggatt tcgccggcat ctacgcctcg acggatcttt tcgtcggtgc ccttgtggac
    16921 attgccaggc acccagacct tattcagcct ctccgccaag agatccgcac tgtaatcgga
    16981 gaagggggct ggacgcctgc ctctctgttc aagctgaagc tcctcgacag ctgcatgaaa
    17041 gagacgcagc gaatcaagcc ggtcgagtgc gccactatgc gcagtaccgc tctcagagac
    17101 atcactctat ccaatggcct cttcattccc aagggcgagt tggccgctgt ggctgcagac
    17161 cgcatgaaca accctgatgt gtgggaaaac cccgaaaatt atgatcccta ccgatttatg
    17221 cgcatgcgcg aggatccaga caaggccttc accgctcaat tggagaatac caacggtgat
    17281 cacatcggct tcggctggaa cccacgcgct tgtcccgggc ggttcttcgc ctcgaaggaa
    17341 atcaagattc tcctcgctca tatactgatt cagtatgatg tgaagcctgt accaggagac
    17401 gatgacaaat actaccgtca cgcttttagc gttcgtatgc atccaaccac aaagctcatg
    17461 gtacgccggc gcaacgagga catcccgctc cctcatgacc ggtgctaaga tataacacgc
    17521 aaactaaaac aaatatgcat ccgtccccag gcttattcca atagtttccg tcccagagaa
    17581 actaggtgct gtattagtcg agtaggttag taaaataaaa cgcattttat tcgattgtga
    17641 tgccttcttt gtaatcgaac gtggtgtaga ctttggctat gtgcgagaga cagaaacaca
    17701 gagagagaga agggagagag tgtgtattcc tgctacgcag agcggccatc tgcttctata
    17761 ccgccagcta caccgccacg tagggaagtc ggcagtaatg aagcttttct cccggtacaa
    17821 tcaccgatct ccccattctc tcaggcgttg actggcgctt acgatgacga gggcttaggc
    17881 tctgttaagt cttgatgttc ctactcaaca tccccgacta ggcgaaagag aggacggcgc
    17941 aacgacgtgg acacaagtac tccctcccgc cttccgacta catatccaca atctgtaccc
    18001 actgcccgtg ccaacgcctt tcgaccgttc aacgcgcatt tacaaggctt gcgggaatca
    18061 taatggagag aaaaagagag aacttttgac agtcaagcct ccgaggtgct aagacagctt
    18121 ccctggtagt ataaaaagca ttcactcttc cgacttcgag aacgagtgca catgtgtact
    18181 ttgttgcttc tcagggccac tgtaatggta tttcaggtat ctctatttac tgctatccag
    18241 aagtcaggca ttaaatagtc aggctcagcc caggctcgat tcagattgga ttcaggcttc
    18301 agaccatggc cgctatgctc cttcgtacta tacctccgtc gagctatacc cgcttggcca
    18361 gacaaaaggc ttcactgaac ccttcaactt aactgcattt cgccacaact aactcgacga
    18421 ggccggcgat ggtgttacca ttcatgagct caaagatcga cacatcaaca tggatttcag
    18481 atgtgatcca gtttcgaagt tcaatggcga cgagtgagtc tacgccgaca cctgccaggt
    18541 ttttggacga ggacatgtcg tcttctgcca gaccaaacat tcgcatcagc ttttccgtca
    18601 ttgctttgag gacgatagaa atggcctcgt cgtgagaggt gaccctgctt agttgggccc
    18661 gcacgccatc tggtcctttt ttatgcgaag agacaaagga ttggtctgca tgaaggactt
    18721 ggcggtattt aagtcccaca aaccgctgtt cctgtatcca gtttgcctcg gtccagtgag
    18781 cacccgggga tgtgttgatt cctgtaacca cagctgcggg aggtgatgga aattgagggg
    18841 aagaacacag gattgccttc tccaacacat ccatgacgtc cttttcatgc ataggcttgt
    18901 aacctattct agcgagccgg tcggccacac cacggccagt ttcagccacg tatccaacag
    18961 acttgaccat gcccaagtca atggtgacag ccggcatgcc atgggctctc cggtggtgcg
    19021 caagtgcgtc ctggaatgca ccagcagctg cgtaattggc ctggcctgcc ccacccatga
    19081 ccccaacaag ggatgagagc atcacgaaga agtcaacatc ctgtgcgatc ttgtgaagat
    19141 accaactacc ctgtactttt gggcgtgttg ctgcattaaa ttcatccaat gtcattcgcg
    19201 atagaagcgc gtccttgaga accatggcac cttgtatgat acctcgaatt ggcggtgcat
    19261 gtgcttcttc gcacaaccgg agcaccttgg tgacctgatc ttgatctgag atgtcacatg
    19321 cgtgtagata gacagcgcac tgttgatttt gcaagctggt tatgaatgga ctggcctttg
    19381 cacttctcga taggataatc aagtgcttcg cgccatgatc aacaagccac tgacagatct
    19441 gctttccaat tccccccagc ccaccagcaa ctaggtaaga actgtcaggc ttcagcttca
    19501 gcgagaaccc tccatcgccg actgggacca gttcgtcccc agatacattg accacaactt
    19561 tgccaacatg ctgaccactc tgcatcgtac ggaaggcctt ctcgatgttt gacaaggagt
    19621 gctgctggat tggaccaatc aagccaatcg cttttgtctc gaggagtttt gtgacatggt
    19681 tcaacgcttc ggatacttct tcacttttgg ctctttgcca cgagagaaga tcaattgatg
    19741 tgaaagagac gtcccgggtg aatggcagca tgtcaagtct gctgttttgc tccaggtcct
    19801 tttttccaat ctcaacaaat ctgccgaatt cggccatgca gtcaaagctt gcttggagga
    19861 gttgacctgc caatgagttt agaacgacat gaacgccaag tccgcccgtg taggctttga
    19921 tgccgtcgac gaataagtca ttcctgctcg agaagatatg atccggattg atgccgaatt
    19981 tatcgccgac aaagtcacgc ttggcttgag ttcccgctgt gacgaagacc tcggcacccg
    20041 caagctggga caaaatgatc gctgcttgac cgacgcctcc agctccactg tggatcaaga
    20101 ctctttcgcc tcgtcgtagc tttgccgtgg tataaagcgc aatatatgcg gtagtgaaag
    20161 ccagggggac cgaagcggct tctgggaagc ccatttcgtc cggaatacgg acgacattag
    20221 tgtacggcgt ctgtgttctg gtcgcccaat ggcctttcag tagtgcacat acgcggtccc
    20281 ctaatctgag gccttggcta gcggcagcag ctccaccgag ctttgtgatc actccggcgc
    20341 attcgaagcc catcacacgg ttggcctcca attgacccat ggcaaccatg acatcccgaa
    20401 aattgagacc gaaagctttg ggttcgattt ctacccaatc atccggaaga tccttgcctt
    20461 cacgtccttc gtcgtctcga aattgcaggg agtctaagag ccctggcgtc tcaacctcca
    20521 tccgcagacg acgcccgggt tgctcgaacg gctgcagtgt gacctcaacc gcttcttggt
    20581 ccttccagtg cgggtcattg aaaagtcgcg gtacgtggat gacgccgttt ctctctgcaa
    20641 attcaaactc cttgtcttcg gaaaggtcgc cgaggcggcc attgaagata ttgcagatag
    20701 catacaggga ctcgtgggtg tatgcgtttc gagaaggatc gagatccaac gatacatatt
    20761 ccttcccgtt attttcgttg cggatggtac gcagcagacc aatatgtaga gctttccatg
    20821 gatcctcgga gctcatggct gctcctctag acacccagag aagtgcgttg cagttattca
    20881 gcatcgcggt gatggatttg aaggtctcgc ttcccacctc tccaaggagc gaggactcca
    20941 tttccccaag aaaaatgcat gtccttccag tggtatctac ctcgcccaga gcgttgatcg
    21001 atgggctaga actggtcttt tcacaaattg ctgcctggag actttccagc caagatgaag
    21061 gaggtcggag cgctccgtgc agcaaaagca cctccgattc tgccactgta tccggggttg
    21121 tattctcttt tctagccgtc gatagcattg tgctgatcat gtaaaactca tcgtcttcac
    21181 aatcacgaac ctccaattcc acaccgttga aaccgctcgt gtccaacatg gtgttccaaa
    21241 gatcggtagt gagcgatggc gtcgacttcc gctcaggctc ctcactgagc caccaacctg
    21301 gcaacagtcc gaaggtaaag aacaaatcga gctgatccct ggtagtctca accaaaatca
    21361 agttgccccc aggcttgagc aattttcgaa cgttactcag tgttcgtttc atgcatcgag
    21421 ttgcatgcag gacctggcaa gccacgacca catcgtaggt ggcacattca aacccttgtt
    21481 gctcgggatc gctttcaata tccaattttt tgaaagtcat cacgtcttgc caatccgcaa
    21541 attgctcacg cgccgactcg aaaaacccgg cagacacatc ggtgaagtca taacgatcga
    21601 tcggcttggt gtttcccaat gcattgacaa taagctttgt gcagccgccc gtgcctccgc
    21661 caatctccaa aatgcgagaa cgcgggttct tgtgggcgca aagtcggatc agctcgctgg
    21721 cttgtgcgtt tgatcggctc catttgattg cgttgacgta gtatctgctt agcagctgat
    21781 cttgcatcat caactcaagt ggctctgttt cgcggcgtag cattgctatt aactgaggtc
    21841 ctagacgaga aatcatctcg ccattgacgc tttctccagc gactctggcc tgtaggcatt
    21901 tcttctgctc agcatcgtca cttagccagt cgcaactggc tgggctgagc ttgttttgtc
    21961 tcgcaaggtc caattggaca ttcatccaat cgaaatactt ctgaaggtgg ccatccagat
    22021 gttggatatc agaatttgtc aaatcagtga cagcctcctg tataaagttg atcgtgcatc
    22081 ttcggaggtc catcatgagt tccgtttctt tcgtctcagc ctcagtgctc aacttttctt
    22141 tgagccaagt ggagtcaccc aagctgatgt caggggccca aacccaggag ctgcaggcat
    22201 tttctgtgtc gttggagtct gacttttggt cagagaagct gcttccaacc gactggaaaa
    22261 caaggccttc aatctctatg actgggattc cgtccgaggg agaagaaccg ctatcatagt
    22321 catcaaacac tgccaagtcg gtagagaagg attgagagtt gcgatccttg atgctggcct
    22381 gtgcgtccag agcatcacca gcctccaagt cagccaggct agaggatatt ttgacatttc
    22441 ttagcctcct tggtaccatg gccgttttca tacgtgttcc cgcgtagggt aacaccgtgt
    22501 atgccgcctg gatcaccgag tccagagtag taggatggac gatgtgtcga ttctcgtacg
    22561 agtgaggcat agccgaggca gtgtcagcaa tggaaaatct gcaaaacgag ccctgtccat
    22621 tgttttgaat tcgctgaatg ttctgaaaaa tgggtccgtg gcatatccca ttcgcgtgta
    22681 aggactccca gagatcgttg ggatcaatgc tccggttatc tgagcctaga ttcaacctgc
    22741 gtgaggcttc cacagttgaa cagtcaaggt ggcttctttc gctctccgaa cgtattaatc
    22801 cggtgcagtg ttctgtccag gtattatttt cgcccgaaat tgagtgcaca gaaaattgat
    22861 gccagttctt tgtgccgagg gacctttcct cacatgaacg gatcgttagg cgcaggtcaa
    22921 cctctgcttc tgcatcagcg ggtattatga gagcctgcgc gagttcaacg tcacgcaagt
    22981 tgtagttgat gctagccccc gcaactggtg ggcagacttg tgaaaacccc tcgatggcca
    23041 tgctgatgaa gccagctccc ggaaagatga tgctcgaacc aacgacgtga tctcgtatcc
    23101 atggaatatc tgacagacgg agaacatgtt tccatttagg cgcgaattga ggagagagag
    23161 attcccgtga gcctatcaaa gtgtgaggcg gatgggttct ctgtttggac tcacgactgc
    23221 cgcgaggctc tctccaataa cgggtttggt gattccacgg gtacgccggc aaatcgctca
    23281 gtaccttcac tctgggctct tttcttccat gaggaaagtt tatagcgtcc attttgagcc
    23341 cataaccctt gcttatcaac tccgtagcag cacgatacat tgtctccaac gagcttctgc
    23401 cgcgagaaag gcaactgaga tagtttatat ctgttccttt cagacccaga tcctgcatga
    23461 cttggttgat tggaccacca agcgctccgt gaggccctat ttcaataatc acatcgacgg
    23521 ctttctcttt ggtgttggga tcaaagcaca tctcgcggag tgaggactcg aactctaccg
    23581 gctgtagcat actatccatc cagtgtgtgg gatccaatag caatttaaga tcggtcatgc
    23641 gactaccagt cttaggtgat gaatataata caccctttga ggtgtcagca ttgggattgt
    23701 cgttgttgtt atccgagttg aacagatctc tcagtgacgc cccaaaggca tctgccattg
    23761 gtcgcatgtg gcttgaatgg aaggcttcag tgactttcag tttcctggta aagatgccat
    23821 cggcgtgtaa caacttttca agtttctcga ttgcacccaa atctcccgac accgtcacac
    23881 tacattgact gttgatacat ccaaccacca cacagccgtc ctcctggttg agacgcgaaa
    23941 tgtaaacatt ggtctcactg cgaccaagac ccaccgccat cattcctcct ttggctgcca
    24001 atgcgggctt gggcttagtg gtcaatacac cgcgtatata agtgatccca atggccgacc
    24061 gcgcggataa agccccagct gcgtaggcag cagcagcctc tccacttgag tgactggtta
    24121 tccccgttgg ccgaattccc catgaccaaa ggagacgcac aagtgcaatt tggatagcgg
    24181 ttgacagtgg tagactgtat tcggcatcat ttacccgagt cgtcagctca tcacggtgga
    24241 gctcctctgt gcaattgaat gttagtacct caagcttgat acagtattac ttttcccggg
    24301 ctcgcaactt acccataaaa ttccaactcg cgcccagttg cttgatgtag ccatcacatt
    24361 caagaatcgc ctgtttgaat actgggaatg tattgaccag ctctctgccc attgcatgcc
    24421 actgcgcccc ctgaccggtg aatacaaatc cgagccgtac tttctcattc gctcgttttg
    24481 gttgattgga ctcatcgctg agggcagaaa caaggccgcc aaggctgtct gctacataca
    24541 ctgacgtcca tggcagaatg gaacggcgag agcctagtgt ataggcgagg ctggcgagga
    24601 agggttcccc gtcaatgtca gcgacggatt taatgtagtc tcgcaggctt gctatcgttc
    24661 gccgacaagc ttgctcgtcc ttggcacgca caacgtatat gcggctctgt ttggaaccat
    24721 cctcaaccct accatgctca gagttaccat tgacatgcac ttgatcctct ggcagggcca
    24781 atgatgcgcg atcatatgat tccaaaatga cgtgagcatt cgaaccacca aagccgaagt
    24841 tattgacaga tgcgcgacga gtcccatctt tcacaggcca gtcttgagca gacatgggga
    24901 tctttgaaac attaaccttt gaaacatata actgaatctg cgaatgcgca aagccttacc
    24961 ttgatgttct tttggtcaag catcagcttg ctgttctttt gcaggaaccg cgcattaggg
    25021 ggaatcaagc ccttctccaa ggccaaggcc accttgatta tactggccag gccactggcg
    25081 gcttctgtat ggccaatatt tgctttcaca gagccaaggt gcagaggatg tcctttaaaa
    25141 gctgctgaaa ttgctgagat ttcaaggggg tcaccagttg gtgttccagt tccgtgggcc
    25201 tccacgtacg aggtcaacga catatctagc ccagccttat cgtaacactc ctggatcaga
    25261 cttttctgcg ccacatcact cggcgcagta attgcgggtg ttttgccatc ctggttcagc
    25321 gctgtctctc gaatgacggc tcggataggg tcttggtctc gcaacgcgtt agggagggcc
    25381 tttattacca gagcggcaat tccttccccg cgaccatatc cattcgctcg aggatcaaaa
    25441 gagtacgaga taccatccgg ggacaaaaat ctgtcattga gcaacaagga ttgcttagtt
    25501 caagactctc gatctggaat cttcttcgga aaactcaccc caggtttgac atcgtaacaa
    25561 aaacatcggg attgagcaga agatttgcac cgataacgat ggctgtatct gactccccag
    25621 tacgtaagct ctggcacgcc aagtgcagtg cggtcaatgt cgtcgaacag gccgtgtcaa
    25681 ccgtcacgct gggaccacgt aagtcgtaga agtgtgatat ccggttcgaa agcattgttc
    25741 ctgagttgcc agttatgaaa taacgcggaa ctgtctcggg gtcacgattg agcgaatcct
    25801 gatagtcgtg gtacatgaca cccccaaaca ccgacgtatt agagcctgcc ataccatcga
    25861 tggtgatacc ggctggatga tggtcagtga cgtttgctta cagtgaggat gacccacact
    25921 acataccact ctccagcgat tcgtagacca cctcaagcat aagccgatac tgcggatcca
    25981 tgcactgtcc aatattagat ctctgcgtcc cgggttagat caattgaaat aatcatacgc
    26041 tggcgacctc tgtggtcatg ttgaagaacg cggcgtcaaa taaagcagga tcctcgtcga
    26101 tgaagtgtcc accctttacg tgggtctatc cagtcatcct tggagtcagt aaccaagctt
    26161 cagtgatgct caaatcttgt gtcaaatatt caaaacaaga tataaatgca tgcatgttag
    26221 atactcacgg acccgaccct ttcgccattc gggtggtata ctcctctcac attgaatcgc
    26281 gaggagggga ccttagacca ggcactgcct cctctttcaa ccatttccca aagcttctgt
    26341 ggactcgttg catctccagc aaatcgacat cccattccaa ctatggcaat gggcgtggat
    26401 gtgttagagc aagccgagcc tgccattgcg gttgcggttg cggttgcggt tgcggttgcg
    26461 gttacggcgg gggtattgtt cattccaacg ttgtttcatt gactgatata tcagtcgccc
    26521 tggtgataaa accgttgata gtcttccaac agtctacagg tccctggcat agctatagat
    26581 gcataagctg cccccgacac gtgattcata gttcggggtt tgttttcatc ttggacgtga
    26641 cacgatattc gctctgtgcc catgggaaac cccggaccac catgctatgc tcggggcaat
    26701 accttagagg taccggttcg ggaggcattg tctgtcgtca cgataatccc gagtcaaaac
    26761 gccgatggga aaccgtcgaa caagacgaaa caggtcaggc cggccaggta gttttcgggt
    26821 ataatggagg ctgtcagaat ccgatactcc gtacacagat gcgaaatacg catacgagct
    26881 atcaaaccaa acgaatccaa aagccttgga aaagcttgga aaggcttagt gggtaatcct
    26941 gtcccaaggt ttgttgaggg cctgagcgca gggtgggtcc tgtaagcagt tggtaattca
    27001 atttccaaca atacacaatc cccaaaattt gcattatcgg ttgactaaga caagcaaaca
    27061 aaatatatgc aggaagcgca attcatcgcg agcaaacgat catcatgagc atgtgaccct
    27121 ttcctctttt ttctacttcg gaaggcggca tgatcatctg tcagaactcc caatcgggag
    27181 caataccata ccttacggca ccccactcag acccatgcac aaagaaaatc catgcgccga
    27241 atattgaagc cttggcaaca aagccccgtg taactccgaa ggtatccaaa gaccgagaga
    27301 cgccgatttg agagacacgt acggaggtcc acacaaaatg ttcccgagtc tatacactat
    27361 actccaaact gacttcttgt ctacctgggt atcttgttca ggttgctgtt tactgagata
    27421 aatgataccg gggggggggg gggggggggg ggttgacact ggcttttcgt ggacagaata
    27481 atacccatac atccctgcgt aagtagtcgt ttcgagaaga atgtgtttcg tggtgcatta
    27541 ctccgtaggc acaatatatt tccattcctc acgaagtggc ctcgtccggg cgtgatcgat
    27601 gcagcttgcc gccccaccaa aaaaggacca caatacgagt cagattagaa acgtctaaca
    27661 ggacgtctat gtaagaggac gctcctttgt atgtcggatc taggcatgac aaaataacta
    27721 tacctaggta gtgttctgtc ttattggtca tttggcctac tttcggaaca atcttggaag
    27781 ttcacattcc taggtatcag ggcaattgat tggtgtcccc agaattcttt tttctcgaat
    27841 aaaggataaa tttatgcata aaaaccttgg aaactgagca tagttatgag cacaaatact
    27901 agttttcagt gcaattggtc ctactatcct ttgcttggta ccccttacca attataccct
    27961 aggcagcagt tgacaccggt catgaatcca ttcataaagg tggaccagat gcagggataa
    28021 ggaagcgaat ctttccgctg cctcagcctc aggggcgcgc gccatttgtt attttcttct
    28081 actcatttcc cgtacctagg aactgttcag ttgtccctcc caaccccttg ggccgaacaa
    28141 ccttcctcca atctacgacg gcagattata cctaggcgcc taaccgatta ggttgctcat
    28201 tcgattttgg aggtatgcac tttatctcaa gccctaattc ccaattgaag tgcttttccg
    28261 tccccatttg cagagctgac tagattcttt tctcagagac tacctagcta taggtaccac
    28321 tccaagctgt agcacagacc tttcagcatg gtcgcttcgt tgctaccctc tcgctttcgc
    28381 ggtagggaat caatgaatca gcagcaccct ctacgctcgg gaaatcgggc attgacctcc
    28441 acactccaat ttctatccaa aacggcgtgt ctacacccga tccataccgt ttgcaccata
    28501 gctattctag ctagtaccac atacgttgga ctactcaaag acagcttctt ccatggcccc
    28561 gcaaacgttg ataaagcaga atggggctct ttggtcgaag gaagtcgaag cttgatcacc
    28621 ggcccacaga atggctggaa gtggcagagc ttcgacgggg atgcagatgt tctcggagat
    28681 ttcaaccatc aagcactaat gaccttggta ttcccggggt catatggggt tgcatctcaa
    28741 gcagcctcac cattccttgc tcccctccct gtgaacctat ctgtgattga ccttccctca
    28801 acgtcgagcc ctttaaccgc ctattcgaaa gataaagttt tcgccttctc tgtggaatac
    28861 agcagcgcgc cggaactcgt ggctgctgtt caagaaatcc ccaacaacag tgccgacctg
    28921 aaattgcagg agacgcaatt gatcgagatg gaacgccaga tgtggatcat gaaggctgcc
    28981 agggctcaca caaaacgcag ccttgctcaa tgggtgcacg atacctggac agagtctctt
    29041 gatcttatca agagcgctca aacgctcgac gtggttgtca tggtgctagg ttatatatca
    29101 atgcacttga ctttcgtctc actcttcctc agcatgaaaa aattgggatc gaaggtttgg
    29161 ctggctacaa gcgtcctttt gtcgtcaaca tttgcctttc tcctcggtct cgacgtggcc
    29221 ataagactag gggttccgat gagcatgagg ttgctatccg aaggcctccc cttcttggtg
    29281 gtgatcgttg gctttgagaa gagcatcact ctgaccaggg ctgttttgtc ctatgctgtg
    29341 cagcaccgaa agccccagaa gatacagtct gaccagggta gcgtgacagc cattgctgaa
    29401 agtaccatca attacgccgt acgaagcgcc attcgggaga agggttacaa tatcgtgtgc
    29461 cactacgtgg tcgagatcct gctcctagtt atcggtgctg tcttaggcat ccaaggtggg
    29521 ctacagcact tctgtgttct agctgcattg atcctgttct ttgactgtct gctgctgttt
    29581 acattctaca ctgcgattct gtctatcaag ctcgaggtaa accgcctcaa acgtcatatc
    29641 aacatgcggt acgcgttgga agatgagggt ctcagtcagc ggacggcgga gagtgtcgcg
    29701 accagcaatg atgcccaaga cagtgcacgt acatatctgt ttggcaatga tatgaaaggc
    29761 agcagtgttc cgaagttcaa attctggatg gtcgttggtt tccttatcgt caacctcgtc
    29821 aacatcggct ccaccctttt ccaagcctct tctagtggat cgttgtccag tatatcatct
    29881 tggaccgaaa gtctgagcgg atcggccatt aaacccccgc ttgagccctt caaggtagct
    29941 ggaagtggac tagatgaact acttttccag gcaagagggc gcggtcaatc gactatggtc
    30001 actgtcctcg cccccatcaa gtacgaacta gagtatcctt ccattcaccg tggtacctcg
    30061 cagctacacg agtatggagt tggtggaaaa atggtcggta gcctgctcac cagcctggaa
    30121 gatcccgtcc tctccaaatg ggtgtttgtg gcacttgccc taagtgtcgc tctgaacagc
    30181 tatctgttca aggccgccag actgggaatc aaagatccta atctcccgag tcacccagtt
    30241 gatccagttg agcttgacca ggccgaaagc ttcaacgctg cccagaacca gacccctcag
    30301 attcaatcaa gtctccaagc tcctcagacc agagtgttca ctcctaccac caccgacagt
    30361 gacagtgatg cctcattagt cttaattaaa gcatctctaa aggtcactaa gcgagcagaa
    30421 ggaaagacag ccactagtga acttcccgtg tctcgcacac aaatcgaact ggacaatttg
    30481 ctgaagcaga acacaatcag cgagttgaac gatgaggatg tcgttgcctt gtctttgcgg
    30541 ggaaaggttc ccgggtatgc cctagagaag agtctcaaag actgcactcg tgccgtcaag
    30601 gttcgccgct ctatcatttc gaggacaccg gctaccgcag agcttacaag tatgctggag
    30661 cactcgaagc tgccgtacga aaactacgcc tgggaacgcg tgctcggtgc atgttgcgag
    30721 aacgttattg gctatatgcc agtccctgtt ggcgtcgccg gtcctattgt tatcgacggc
    30781 aagagttatt tcattcctat ggcaaccacc gagggcgtcc tcgtcgctag tgctagccgt
    30841 ggcagtaagg caatcaacct cggtggcggt gccgtgacag tcctgactgg cgacggtatg
    30901 acacgaggcc cgtgtgtgaa gtttgatgtc cttgaacgag ctggtgctgc taagatctgg
    30961 ctcgattcgg acgtcggcca gaccgtaatg aaagaagcct tcaattcaac cagcagattt
    31021 gcgcgcttac aaagtatgcg gacaactatc gccggtactc acttatatat tcgatttaag
    31081 actactactg gcgacgctat gggaatgaat atgatttcta agggcgtgga gcatgcactg
    31141 aatgttatgg cgacagaggc aggtttcagc gatatgaata ttattaccct atcaggaaat
    31201 tactgtacgg ataagaaacc ttcagctttg aattggatcg atggacgggg caagggcatt
    31261 gtggccgaag ccatcatacc ggcgaacgtt gtcagggatg tcttaaagag cgatgtggat
    31321 agcatggttc agctcaacat atcgaaaaat ctgattgggt ccgctatggc tggctcagtt
    31381 ggcggcttca acgcccaagc tgccaatctt gcggcagcca ttttcattgc cacaggtcag
    31441 gatccggcgc aagttgtgga gagcgctaac tgcatcactc tcatgaacaa gtaagttgaa
    31501 agcggccgct tacttggaaa cattcactaa tcctgtttag tcttcgcgga tcgcttcaaa
    31561 tctctgtctc catgccgtct attgaggttg gaacgttggg cggtggtacg attctggagc
    31621 cccagggcgc aatgcttgac atgcttggtg tccgcggatc acacccgacc actcccggtg
    31681 agaatgcacg tcaacttgcg cgcatcatcg gaagcgctgt tttggctggg gagctctcgc
    31741 tatgtgctgc cctagccgcc ggtcacctgg tcaaggcgca catggcgcac aaccgttctg
    31801 ccccggcatc ttcagcccct tctcgaagtg tctccccgtc aggcggaacc aggacagtcc
    31861 ctgttcctaa caatgcactg aggccgagtg ctgcagctac tgatcgggct cgacgctgat
    31921 taggtcggaa tcttaggagc attccaagct ccgtaccccc tccagtggat tcattgcagg
    31981 aggatcatat tttttctcat tggttgttat tgtcataatt ttcaaaagca caatgcaatg
    32041 agacaggcag gtggtagagt gaacggccag aaagggtatc tcatgtttat atgttgttga
    32101 aatttacgat gcaagtagta gggaagaaga atatataaag agatggtcct tttccagaga
    32161 gtgtttaggt ctgatccctc ataattattt aatgagtgaa agctttgttc aagctataac
    32221 ttactgagta ggttgaatgt tgatctgatt cattcctgag gtatcaggat tgatgcctga
    32281 aacatcaatc atccattgtc agatgccgta actaactaac tatgaatctc aacatagtta
    32341 tatgttgcca atctagccac ggtgactaga accttgagat ggacttagac tagacatggg
    32401 tcgcgggcaa tgacatatag aatctttgaa atcgacatta attaagtatg tggagattct
    32461 ttgtggaggc acggtaatgt gtctatctag caacgcggtc aagcatcagt ctcaggcaca
    32521 gcccgggtgt cgtttttggt tgcaatcttc cgccatccca ttccaaaggc aaacacaaac
    32581 gtgcacgccg tagctcccac tgctaagtaa aaagtatgat caacggcgag actgtaagct
    32641 tttacaaccc ctggaaggtt attcttgctg accacatctc tgaagccagt cgcccctgct
    32701 gccgtcacgg cctgcgtgtc gacagtgggc gcatacttgc tcaggccagt tctcaaaccg
    32761 gacccaaaga caaggttagc aaagtccagg aagagcgatc ctccaaacgt ctgtccaaac
    32821 acggcgagag aaattccgag ggcaccttgt tcgggcgaaa gcgtgctttg gatggcgatg
    32881 ataggctggc cattgagtat tgatgtcagc gtctagcggt tgcatgctct tcttgctttg
    32941 atacaaagcc gaaagcgtga gagatgatca aaggtttcat agcttaccgt ttgcatgcca
    33001 caaccacgac cgaagcccgc gataaattgg tacatgaccc atttcacagt tgatgtatgg
    33061 ggctggaagg tggataccag acctgcgcct atggcgacga gaacagcgct gcctagggcc
    33121 caaggcaaat agtatcctgt ctttccaact ggtgcgtcat atgtcagtat acacgatatc
    33181 caagcccgat gtcagacggt tgtggcaaga aaggagccat agaaatggac ggggtggaga
    33241 aaaatgtgta cgcgagtttc acttacttgc gaagccagaa accatagcca taatgacttg
    33301 tccaagaatt ccaggcaaca tgtacacacc actcagtgtg ggagaaacat ccttcacagc
    33361 ctggaagtag atcggtagat agtaggaaaa gacaagcaag gagccagaga aaaagcccat
    33421 aaataaacaa gagcaccaca cttgtcgttt accagccact gagccaggaa tcatggcaac
    33481 agcatcgcca acatgacgct cccatagcac gaacgcaatc agagcaaacc ctccgccaca
    33541 gaacaggccg atgatgacgg aacttcgcca ggtgtaggtc gaccctcccc attctagtgc
    33601 gagggaaatc atggttgcga aggctgcaaa gaccacaaag cctacaaggt ccagtttgcg
    33661 aagtgtggat tttatgttgg ccattggttt gtcggtcgag agttcgctgt ccgtggatga
    33721 aattcggtcg ggtatggtga tgacgagaag gaggaatgca gcgacagcgc cgatggggag
    33781 attgatataa aagcctgaat tccaagtgag aacatggaca acaatcataa aaaggccaaa
    33841 ggtcaacata caccatcgcc aagtggcgtg ttgagtgaaa gcacctccga gcagtggtcc
    33901 acagacaatg gcaatctgac taactgaaaa catattgtca gacgacgaac cgttcgtttg
    33961 gggtacatca gatcttgaga tgacatacga cccatcatca ctccaatcaa aacttcatat
    34021 gcgaggtcag cgtgtacacg gcacccagca gacttccaaa aatcggttcc cttacctggt
    34081 tgcttgtgct taggagcagc tgttgagagg attgtgaggg ctccgttgac aagacctgag
    34141 cctcccattc cagcaacggc ccgcccaaca atcaacatgg tggaagatct tgcggcaccg
    34201 catagcaccg agcctagttc aaaaatacag aggaaggcaa agaaagtgta cttcaagccc
    34261 aagagtgtat acaatttacc ggccaggggc tggagagcac agctaaatat gatgttagct
    34321 aatctgttcg tacaatgaac aaggtcaagg agaacagagc catacttagc cagaagataa
    34381 gcactgccgt accaccctac atcgttcaga gagtggaact cgcttgtgat atgtgggatt
    34441 gcctgtggct ggagtcaatt gactgtgctg cgctctgttc tgaggtagcc accatcttac
    34501 cgtgacgata atggacatat caaggagcat caaaaatgct acgaaagtaa ctgaagcaac
    34561 caccagcccg agcttgaggc ctgtgatgtg ctgggacttg gactcagtcg cttcgagcgt
    34621 gtcattttga ctttcttcct tctgtggcct tggttcccct tctttagggg gtagaggttc
    34681 tgacatcgcg caattccttc cgacttttgc ttcaaggggc ggtgtgaatc tctactgcgc
    34741 ggcgcttcta tagtacctgt gttttggtgt atgaatgatc tcgctctcgt tgtttcgtta
    34801 aggtccgcta gcctgaagtc agattgatgg atggggatca ggggaaattg gcgacgtctt
    34861 taattttgct tttctttgtt accggaagtg ttgcggtatt agcgtgtctg ggcttattta
    34921 cgacgcacaa gatgcattga actggcccca ctgctagatc tcactagtat tgtggttgta
    34981 atttacctat actccatatt gactgggcag gttttgaaca caacccacac ccccccatac
    35041 tacacattag ttttgcatat tttcctgggg gccaaaaaaa ccccaaaagg cttcaatatt
    35101 ttgcggccaa tggagagtgt aactaatttg gcccacactc cggtggtatc aatcggatct
    35161 cactgcatat atgatgaaag caagaggggg caggagatac gctctttatt ggctgtctgc
    35221 gcgaagctgg gcaaatgcaa ataaaaagac aaacaaccag ctggaagacc gggcgacaaa
    35281 catggtttac ctaacaccct cgatcccaac aatgtgcatg ttaatcaatg tgctccgtgg
    35341 ggagtatgaa ctataacata cgaagcagcc attcatgtca aaaaaaaaac caggcgaatg
    35401 ggcgtcgtca acggtttcac ataagtacta tattgtacta actacccgtg agactggaga
    35461 gaacagtctc gcgcgaagaa acgataagag catcggtcat atcggtccat ctcggtctaa
    35521 gtgtatgaga atattccgac gtgaatccat ccgtcagtga tcaatgtctc caagtaattc
    35581 atcatttcaa ttaccctcgc tttactccgt agaatacaag accttactag cgcaaacaag
    35641 tgggggctaa cggtgtgatc tccttccgtt gcggccgcca cctcggttcc agccgtaata
    35701 cgacgacccg tctatcgcga ccccctagcc ttggccattt ttggcgttac agtaaagctt
    35761 tggagagaaa cgccaaggga aaatgctagc caccaattct ataaattact cttcacatgc
    35821 agctagtatc actggtaagt ctacggggca catgtaaaat ttttattact ttctaataat
    35881 ctttccaagt tcttttccac ggggccccaa tgcttaaaat actcaaaaga cgtgaaaaac
    35941 ctgcaaggcc gccagtgata tcacacgtaa tgcctcaaca gcctgattcc gagccattat
    36001 atgctgtttg atgatctcaa attgagatgg cgagcgctgg atctgggaaa ttggtagtgg
    36061 gattggtata gaaacgtaag tgcagaagac catgtaataa gtacatatgg aggctatgtg
    36121 atggcccgat ctagtttctt caatatagcg ctgggtataa aaaaaagcag gggctttctc
    36181 agggtaatgt cgcagtctac aacgagtggc gtccactgac agggaaaggc gagcggggct
    36241 atgctacctt caatttccat agagggggga tgcaccatct ccgacaatct atagttactc
    36301 aaacaggtac ggtactaagc aatattgtgt ttcttcgcta atgcgaatat ttccttatag
    36361 caacgtcgca acacatttat cgtcttccct gaggcctttg ttgacttggg ctcttcgtct
    36421 ccggcttcgt cactccaaag cacagatagg agacgagagg ccggcgttat ggttttattt
    36481 tcagcgccaa ggatttgcca cgatgtgctt ggcatatctg ataggaccta ttccccctct
    36541 cccggtcagc gcattgctga tgtatgcaag ggaagaaaag actggtggtt atcggtccca
    36601 cttactagac gaatagatgc cgcagccccg tgctcctgtg ctatccccaa agcagtctca
    36661 atctcactca atagtcgaag gcttacacgc aatgtcgtgc atgcagaaga taaggcgtgc
    36721 atgaatgggt cgagatgtga aatgagctcg ccgatatgaa gattagagtg aaacgaggga
    36781 agtgcttcgg ctcttccatt gtcatttcta gtggttgagc cagaccagta ccaatccatt
    36841 cgtgtgcttt gcttttgtcc acaaggttgg gctttcatca cctcggatag tagcagctgg
    36901 gaaagtgatg tcatgatttt gacagacaac atgtagcaat gcaccgccat gaacaagttc
    36961 ttggtttgca gacacccatc taacatgctg ctattgctgc tcgtgatcac acgttcttga
    37021 agatgtagta gcaatctacc aaaggcattc aaaaagtccc ctatcgggtc taggaagaag
    37081 ctttagcgac aatcaagagg cagtaaacag gcagaattga aaatctcaca gcttaaaatt
    37141 ttttgcttgg gccattccac agtcaccccg tggagtatta cctctaggtc ctgtgacaca
    37201 tccgacagac tttcgaaaag gtctcgttgc gtgttgcttg tgttggattg tccggatgac
    37261 gagttcccct ctacttcgag gtcaaacagc gatggcgaga caggcgccgt tgcatccaaa
    37321 gggccttcaa agtcgtagcc tagatctggt atccccgaag attcattgct gttggcatcg
    37381 tcgcgaaatg tatttggctg aggccagccg ccgggaaacg actcgggatc atcaaagttg
    37441 attgatgtat catagaattg cagggttgcc gctgatggtt ctgataatgt ttccttgagt
    37501 gccgaggtgc caatatgcgt aggtggtgag cagtaaggtg gaggagtctc tgccaatgat
    37561 gagaagaccg tagaagatgt cgcggtcatc ggttgtgagg tttctgtggc tcttgtagtt
    37621 ccagctgcgg cttctttatg taaattgcgc ttgggtagcc tttcgctgta cacacacctt
    37681 aatccggctt gttgacaacg ttgacactga gcacggacta aattggcatt gctaccggta
    37741 catttgagct tttgtgcatg acaccggtca catgagcgtc gaaacgcgcg acggcgtagg
    37801 ttcgtcggaa tcgttgcatg cggcagggac ataattattg gattaagatc aaataatgtg
    37861 aggtgagact ttgcatgttc ctggatcttt atgtattgga attggagagt aagctcgtgc
    37921 aggagataag ttcaggtcgt cttgctggaa gacttactaa gttatatgca aacaagtgtt
    37981 ttcgagcgga caccaaaagc caatagtctt actatgaatg tcttttcagt cacccggaga
    38041 aatactctta gcctctgctc ttatgcgagc tcatcaaagc tgggcataca taccccatcc
    38101 agcgccacgt attacactag aaagagttct aaaagaaata gattcggccc cccatctggc
    38161 tatcatatat gccagatgaa atacctgtaa cgtggggcat aaaaaggcag gctctagtct
    38221 accagcagat c
//
