BGC0000040 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000040 (Streptomyces neyagawaensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	99,892	High	concanamycin A	PKS

BGC0000040 - Region 1 - T1PKS

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Location: 1 - 99,892 nt. (total: 99,892 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 99,893
Label		BGC0000040

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

AAZ94392.1: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

AAZ94394.1: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

AAZ94400.1: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

AAZ94409.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

AAZ94410.1: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: PPTase acylase glycosyltransferase transferase

AAZ94385.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

AAZ94397.1: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

AAZ94402.1: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

AAZ94407.1: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1060: 4'-phosphopantetheinyl transferase

Hydrolases: esterase phosphatase

AAZ94395.1: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

AAZ94405.1: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

AAZ94396.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AAZ94399.1: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

AAZ94386.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AAZ94387.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AAZ94388.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AAZ94389.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AAZ94390.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AAZ94391.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000040.5	0.99	PKS	concanamycin A	Streptomyces neyagawaensis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000040.5	1.00	PKS	concanamycin A	Streptomyces neyagawaensis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0002154.2	0.67	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001160.5	0.66	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 97006:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal) + (Me-ohmal - ohmal - pk) + (pk - pk - ccmal) + (pk - Me-redmal) + (ohemal - Me-ohmal - Me-ccmal) + (pk)
Non-colinear ordering:: AAZ94386.1 + AAZ94387.1 + AAZ94388.1 + AAZ94389.1 + AAZ94390.1 + AAZ94391.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAZ94385.1: pk

PKS_AT (16..271): pk

ATSignature: (unknown)

No matches above 50%

minowa: trans-1,2-CPDA

Prediction, score:

trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

AAZ94386.1: mal - mal

PKS_AT (541..841): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 224.2
inactive: 120.3
Methoxymalonyl-CoA: 62.9
Methylmalonyl-CoA: 48.2
Propionyl-CoA: 34.4
Isobutyryl-CoA: 32.9
Acetyl-CoA: 13.9
Ethylmalonyl-CoA: 13.2
CHC-CoA: 9.7
Benzoyl-CoA: 9.6
2-Methylbutyryl-CoA: 6.7
trans-1,2-CPDA: 5.1
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1555..1862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.8
inactive: 97.1
Methoxymalonyl-CoA: 67.9
Methylmalonyl-CoA: 57.0
Propionyl-CoA: 32.1
Isobutyryl-CoA: 25.0
Ethylmalonyl-CoA: 22.1
Acetyl-CoA: 15.4
fatty_acid: 12.6
2-Methylbutyryl-CoA: 11.6
Benzoyl-CoA: 6.8
CHC-CoA: 4.9
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

AAZ94387.1: mmal - mal - pk

PKS_AT (603..896): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 226.3
Ethylmalonyl-CoA: 217.1
Methoxymalonyl-CoA: 179.5
2-Methylbutyryl-CoA: 165.9
trans-1,2-CPDA: 143.2
Propionyl-CoA: 118.6
CHC-CoA: 118.0
Malonyl-CoA: 115.4
Isobutyryl-CoA: 102.6
Benzoyl-CoA: 88.1
3-Methylbutyryl-CoA: 53.4
Acetyl-CoA: 52.1
fatty_acid: 41.6
inactive: 38.3

PKS_AT (2147..2450): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 229.9
inactive: 115.6
Methoxymalonyl-CoA: 71.7
Methylmalonyl-CoA: 62.8
Propionyl-CoA: 46.5
Isobutyryl-CoA: 26.4
2-Methylbutyryl-CoA: 22.8
Ethylmalonyl-CoA: 21.6
Benzoyl-CoA: 21.2
Acetyl-CoA: 16.9
trans-1,2-CPDA: 13.1
CHC-CoA: 11.3
fatty_acid: 9.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (3757..4054): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 229.9
Methylmalonyl-CoA: 220.4
Methoxymalonyl-CoA: 186.6
2-Methylbutyryl-CoA: 164.1
trans-1,2-CPDA: 130.6
Propionyl-CoA: 125.4
CHC-CoA: 103.3
Malonyl-CoA: 103.0
Isobutyryl-CoA: 92.1
Benzoyl-CoA: 88.3
Acetyl-CoA: 62.9
3-Methylbutyryl-CoA: 40.2
inactive: 28.8
fatty_acid: 22.8

AAZ94388.1: pk - pk - mal

PKS_AT (562..856): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 225.6
Methylmalonyl-CoA: 225.2
Methoxymalonyl-CoA: 181.0
2-Methylbutyryl-CoA: 167.8
trans-1,2-CPDA: 135.3
Propionyl-CoA: 120.8
CHC-CoA: 100.4
Malonyl-CoA: 93.3
Isobutyryl-CoA: 79.6
Benzoyl-CoA: 65.6
3-Methylbutyryl-CoA: 51.2
fatty_acid: 47.9
Acetyl-CoA: 47.6
inactive: 23.0

PKS_AT (2110..2405): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 213.5
Methoxymalonyl-CoA: 207.5
Methylmalonyl-CoA: 203.4
2-Methylbutyryl-CoA: 151.6
trans-1,2-CPDA: 126.8
Propionyl-CoA: 114.8
Malonyl-CoA: 107.5
CHC-CoA: 99.4
Isobutyryl-CoA: 86.2
Benzoyl-CoA: 51.1
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 25.8
fatty_acid: 25.0
inactive: 20.1

PKS_AT (3667..3956): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.7
inactive: 100.1
Methoxymalonyl-CoA: 72.0
Methylmalonyl-CoA: 64.8
Propionyl-CoA: 40.1
Isobutyryl-CoA: 32.9
Ethylmalonyl-CoA: 28.3
Acetyl-CoA: 24.6
Benzoyl-CoA: 20.6
CHC-CoA: 19.7
2-Methylbutyryl-CoA: 19.1
trans-1,2-CPDA: 14.8
fatty_acid: 7.7
3-Methylbutyryl-CoA: 0.0

AAZ94389.1: pk - mmal

PKS_AT (579..877): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 232.9
Methylmalonyl-CoA: 224.0
Methoxymalonyl-CoA: 187.5
2-Methylbutyryl-CoA: 160.2
trans-1,2-CPDA: 130.9
Propionyl-CoA: 122.8
CHC-CoA: 120.2
Malonyl-CoA: 113.4
Isobutyryl-CoA: 88.8
Benzoyl-CoA: 61.4
Acetyl-CoA: 41.8
3-Methylbutyryl-CoA: 40.4
inactive: 34.1
fatty_acid: 32.4

PKS_AT (2335..2629): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.8
Ethylmalonyl-CoA: 213.5
Methoxymalonyl-CoA: 172.4
2-Methylbutyryl-CoA: 145.3
trans-1,2-CPDA: 116.9
Malonyl-CoA: 111.5
Propionyl-CoA: 107.7
CHC-CoA: 94.9
Isobutyryl-CoA: 86.1
Benzoyl-CoA: 81.7
Acetyl-CoA: 54.7
3-Methylbutyryl-CoA: 48.8
inactive: 35.8
fatty_acid: 26.8

AAZ94390.1: emal - mmal - mmal

PKS_AT (597..901): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 251.5
Methylmalonyl-CoA: 211.4
Methoxymalonyl-CoA: 181.5
2-Methylbutyryl-CoA: 144.7
trans-1,2-CPDA: 133.6
CHC-CoA: 121.3
Propionyl-CoA: 107.8
Malonyl-CoA: 99.0
Isobutyryl-CoA: 92.8
Benzoyl-CoA: 85.7
Acetyl-CoA: 51.1
3-Methylbutyryl-CoA: 39.8
fatty_acid: 25.4
inactive: 22.8

PKS_AT (2168..2472): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 219.6
Ethylmalonyl-CoA: 215.2
Methoxymalonyl-CoA: 184.1
2-Methylbutyryl-CoA: 175.0
trans-1,2-CPDA: 128.9
Propionyl-CoA: 122.6
Malonyl-CoA: 108.6
CHC-CoA: 107.8
Isobutyryl-CoA: 85.5
Benzoyl-CoA: 62.1
Acetyl-CoA: 59.5
3-Methylbutyryl-CoA: 34.4
fatty_acid: 33.9
inactive: 28.1

PKS_AT (3729..4023): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.4
Ethylmalonyl-CoA: 205.3
Methoxymalonyl-CoA: 167.4
2-Methylbutyryl-CoA: 155.0
trans-1,2-CPDA: 135.2
CHC-CoA: 115.6
Propionyl-CoA: 108.1
Isobutyryl-CoA: 98.4
Malonyl-CoA: 96.7
Benzoyl-CoA: 79.9
Acetyl-CoA: 49.8
fatty_acid: 40.8
3-Methylbutyryl-CoA: 31.3
inactive: 27.8

AAZ94391.1: pk

PKS_AT (565..863): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Methylmalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 198.4
Methoxymalonyl-CoA: 189.1
Ethylmalonyl-CoA: 177.8
trans-1,2-CPDA: 142.0
2-Methylbutyryl-CoA: 138.5
Propionyl-CoA: 117.8
Malonyl-CoA: 95.6
CHC-CoA: 88.9
Isobutyryl-CoA: 68.2
Benzoyl-CoA: 64.4
fatty_acid: 55.8
Acetyl-CoA: 47.5
3-Methylbutyryl-CoA: 45.9
inactive: 22.6

Link to PARAS substrate predictor