BGC0000041 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000041 (Pseudomonas syringae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	14,402	oronofacic acid	PKS	100%

BGC0000041 - Region 1 - T1PKS

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Location: 1 - 14,402 nt. (total: 14,402 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,403
Label		BGC0000041

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041	1.00	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000024	0.26	Polyketide	aureothin	Streptomyces thioluteus
BGC0001215	0.24	NRP	conglobatin	Streptomyces conglobatus
BGC0001246	0.24	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000143	0.24	Polyketide	salinomycin	Streptomyces albus
BGC0000045	0.23	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0000147	0.23	Polyketide	soraphen A	Sorangium cellulosum
BGC0000094	0.23	Polyketide, Saccharide	methymycin	Streptomyces venezuelae
BGC0001298	0.23	Polyketide	4-Z-annimycin	Streptomyces calvus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041	1.00	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000024	0.60	Polyketide	aureothin	Streptomyces thioluteus
BGC0001215	0.57	NRP	conglobatin	Streptomyces conglobatus
BGC0001246	0.57	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0000143	0.57	Polyketide	salinomycin	Streptomyces albus
BGC0000045	0.57	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0000147	0.56	Polyketide	soraphen A	Sorangium cellulosum
BGC0000094	0.56	Polyketide, Saccharide	methymycin	Streptomyces venezuelae
BGC0001298	0.56	Polyketide	4-Z-annimycin	Streptomyces calvus

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14402:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - redemal) + (ccmal)
Non-colinear ordering:: cfa6 + cfa7

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cfa6

PKS_AT (150..431): mmal

ATSignature: Propionyl-CoA, Ethylmalonyl-CoA, CHC-CoA, Methylmalonyl-CoA, 2-Methylbutyryl-CoA

Top 3 matches:: Propionyl-CoA: 58.3%; Ethylmalonyl-CoA: 58.3%; CHC-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 89.6
Methoxymalonyl-CoA: 83.6
Ethylmalonyl-CoA: 73.4
CHC-CoA: 67.6
Propionyl-CoA: 61.1
2-Methylbutyryl-CoA: 55.9
trans-1,2-CPDA: 54.2
Isobutyryl-CoA: 26.5
Benzoyl-CoA: 22.9
3-Methylbutyryl-CoA: 21.0
Malonyl-CoA: 16.6
inactive: 15.7
fatty_acid: 8.1
Acetyl-CoA: 7.0

PKS_AT (1138..1435): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.5
Methylmalonyl-CoA: 172.8
Methoxymalonyl-CoA: 134.0
2-Methylbutyryl-CoA: 102.1
Malonyl-CoA: 100.2
trans-1,2-CPDA: 92.5
Propionyl-CoA: 79.7
CHC-CoA: 74.3
Isobutyryl-CoA: 62.4
Benzoyl-CoA: 57.6
inactive: 26.3
Acetyl-CoA: 25.8
3-Methylbutyryl-CoA: 25.4
fatty_acid: 19.7

cfa7

PKS_AT (573..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 66.7%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.8
Methoxymalonyl-CoA: 96.3
Methylmalonyl-CoA: 94.2
inactive: 75.5
Propionyl-CoA: 66.7
Isobutyryl-CoA: 54.7
Ethylmalonyl-CoA: 51.8
Acetyl-CoA: 45.9
2-Methylbutyryl-CoA: 41.5
trans-1,2-CPDA: 34.1
CHC-CoA: 29.3
fatty_acid: 25.7
Benzoyl-CoA: 17.2
3-Methylbutyryl-CoA: 15.0