BGC0000041 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000041 (Pseudomonas syringae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	14,402	actinoallolide A	Polyketide	20%

BGC0000041 - Region 1 - T1PKS

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Location: 1 - 14,402 nt. (total: 14,402 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 14,403
Label		BGC0000041

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.25	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000056.1	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000143.1	0.24	Polyketide	salinomycin	Streptomyces albus
BGC0000157.1	0.23	Polyketide	tautomycetin	Streptomyces sp. CK4412
BGC0002030.1	0.21	Polyketide	viriditoxin	Byssochlamys spectabilis
BGC0001866.1	0.21	Polyketide	viriditoxin	Byssochlamys spectabilis
BGC0002026.1	0.21	NRP	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0001298.1	0.20	Polyketide	4-Z-annimycin	Streptomyces calvus
BGC0000147.1	0.20	Polyketide	soraphen A	Sorangium cellulosum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.1	0.87	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000067.1	0.59	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000056.1	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000143.1	0.57	Polyketide	salinomycin	Streptomyces albus
BGC0000157.1	0.56	Polyketide	tautomycetin	Streptomyces sp. CK4412
BGC0002030.1	0.54	Polyketide	viriditoxin	Byssochlamys spectabilis
BGC0001866.1	0.54	Polyketide	viriditoxin	Byssochlamys spectabilis
BGC0002026.1	0.54	NRP	thaxteramide A1, thaxteramide A2, thaxteramide B1, thaxteramide B2	Jahnella sp. MSr9139
BGC0001298.1	0.53	Polyketide	4-Z-annimycin	Streptomyces calvus
BGC0000147.1	0.52	Polyketide	soraphen A	Sorangium cellulosum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 14402:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - redemal) + (ccmal)
Non-colinear ordering:: cfa6 + cfa7

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

cfa6

PKS_AT (150..431): mmal

ATSignature: Propionyl-CoA, Ethylmalonyl-CoA, CHC-CoA, Methylmalonyl-CoA, 2-Methylbutyryl-CoA

Top 3 matches:: Propionyl-CoA: 58.3%; Ethylmalonyl-CoA: 58.3%; CHC-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 89.6
Methoxymalonyl-CoA: 83.6
Ethylmalonyl-CoA: 73.4
CHC-CoA: 67.6
Propionyl-CoA: 61.1
2-Methylbutyryl-CoA: 55.9
trans-1,2-CPDA: 54.2
Isobutyryl-CoA: 26.5
Benzoyl-CoA: 22.9
3-Methylbutyryl-CoA: 21.0
Malonyl-CoA: 16.6
inactive: 15.7
fatty_acid: 8.1
Acetyl-CoA: 7.0

PKS_AT (1138..1435): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.5
Methylmalonyl-CoA: 172.8
Methoxymalonyl-CoA: 134.0
2-Methylbutyryl-CoA: 102.1
Malonyl-CoA: 100.2
trans-1,2-CPDA: 92.5
Propionyl-CoA: 79.7
CHC-CoA: 74.3
Isobutyryl-CoA: 62.4
Benzoyl-CoA: 57.6
inactive: 26.3
Acetyl-CoA: 25.8
3-Methylbutyryl-CoA: 25.4
fatty_acid: 19.7

cfa7

PKS_AT (573..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 66.7%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.8
Methoxymalonyl-CoA: 96.3
Methylmalonyl-CoA: 94.2
inactive: 75.5
Propionyl-CoA: 66.7
Isobutyryl-CoA: 54.7
Ethylmalonyl-CoA: 51.8
Acetyl-CoA: 45.9
2-Methylbutyryl-CoA: 41.5
trans-1,2-CPDA: 34.1
CHC-CoA: 29.3
fatty_acid: 25.7
Benzoyl-CoA: 17.2
3-Methylbutyryl-CoA: 15.0