BGC0000042: cremimycin biosynthetic gene cluster from Streptomyces sp. MJ635-86F5
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Location: 1 - 105,855 nt. (total: 105,855 nt).
This entry is originally from NCBI GenBank AB818354.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000042
Short description cremimycin biosynthetic gene cluster from Streptomyces sp. MJ635-86F5
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB818354.1
via
Compounds
  • cremimycin
Species Streptomyces sp. MJ635-86F5 [taxonomy]
References
Chemical products information
cremimycin Evidence:
Copy SMILES
C35H53N1O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAO66509.1
 7 - 1047 (-) SAM-dependent methyltransferase
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    • BAO66510.1
    		 1119 - 1610 (-) putative transcriptional regulator
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      • BAO66511.1
      		 1638 - 2312 (-) phosphopantetheinyl transferase
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        • BAO66512.1
        		 2309 - 3163 (-) metallophosphatase
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          • BAO66513.1
          • cmiC1
          		 3580 - 4350 (-) dTDP-6-deoxy-L-hexose-3-O-methyltransferase
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            • BAO66514.1
            • cmiC2
            		 4365 - 5408 (-) 4-ketoreductase
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              • BAO66515.1
              • cmiM1
              		 5489 - 6367 (-) retinol dehydrogenase
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                • BAO66516.1
                • cmiM2
                		 6364 - 7230 (-) xylose isomerase
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                  • BAO66517.1
                  • cmiR1
                  		 7441 - 8211 (+) type II thioesterase
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                    • BAO66518.1
                    • cmiC3
                    		 8269 - 8859 (+) dTDP-4-deoxyglucose 3,5-epimerase
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                      • BAO66519.1
                      • cmiP1
                      		 8973 - 19733 (-) type I polyketide synthase
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                        • BAO66520.1
                        • cmiR2
                        		 20047 - 20802 (-) TetR-type transcriptional regulator
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                          • BAO66521.1
                          • cmiR3
                          		 21016 - 21996 (+) ABC transporter
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                            • BAO66522.1
                            • cmiR4
                            		 21993 - 22838 (+) ABC transporter
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                              • BAO66523.1
                              • cmiM3
                              		 22990 - 23856 (+) carveol dehydrogenase
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                                • BAO66524.1
                                • cmiM4
                                		 23963 - 25201 (-) P450 monooxygenase
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                                  • BAO66525.1
                                  • cmiS1
                                  		 25426 - 26001 (+) putative NRPS accessory protein
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                                    • BAO66526.1
                                    • cmiP2
                                    		 26009 - 28183 (+) type I polyketide synthase
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                                      • BAO66527.1
                                      • cmiS2
                                      		 28258 - 29385 (+) FAD-dependent glycine oxydase
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                                        • BAO66528.1
                                        • cmiP3
                                        		 29390 - 32524 (-) type I polyketide synthase
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                                          • BAO66529.1
                                          • cmiP4
                                          		 32555 - 48247 (-) type I polyketide synthase
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                                            • BAO66530.1
                                            • cmiS3
                                            		 48180 - 49730 (-) nonribosomal peptide synthase
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                                              • BAO66531.1
                                              • cmiS4
                                              		 49840 - 50076 (+) peptidyl carrier protein
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                                                • BAO66532.1
                                                • cmiS5
                                                		 50151 - 51104 (-) acyltransferase
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                                                  • BAO66533.1
                                                  • cmiS6
                                                  		 51284 - 52867 (+) nonribosomal peptide synthase
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                                                    • BAO66534.1
                                                    • cmiM5
                                                    		 53013 - 54254 (+) glycosyltransferase
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                                                      • BAO66535.1
                                                      • cmiC4
                                                      		 54261 - 55259 (-) 3-ketoreductase
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                                                        • BAO66536.1
                                                        • cmiC5
                                                        		 55256 - 56794 (-) NDP-hexose 2,3-dehydratase
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                                                          • BAO66537.1
                                                          • cmiC6
                                                          		 56791 - 57789 (-) dTDP-glucose 4,6-dehydratase
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                                                            • BAO66538.1
                                                            • cmiC7
                                                            		 57786 - 58850 (-) NDP-1-glucose synthase
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                                                              • BAO66539.1
                                                              • cmiP5
                                                              		 59120 - 67081 (-) type I polyketide synthase
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                                                                • BAO66540.1
                                                                • cmiM6
                                                                		 67126 - 68019 (-) putative proline iminopeptidase
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                                                                  • BAO66541.1
                                                                  • cmiP6
                                                                  		 68036 - 74047 (-) type I polyketide synthase
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                                                                    • BAO66542.1
                                                                    • cmiP7
                                                                    		 74047 - 89649 (-) type I polyketide synthase
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                                                                      • BAO66543.1
                                                                      • cmiP8
                                                                      		 89683 - 94560 (-) type I polyketide synthase
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                                                                        • BAO66544.1
                                                                        • cmiM7
                                                                        		 94586 - 95455 (-) xylose isomerase
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                                                                          • BAO66545.1
                                                                          • cmiR5
                                                                          		 95624 - 98380 (-) LuxR-type transcriptional regulator
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                                                                            • BAO66546.1
                                                                            		 98983 - 101670 (+) LuxR-type transcriptional regulator
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                                                                              • BAO66547.1
                                                                              		 102133 - 103728 (-) cyclohexanecarboxylate-CoA ligase
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                                                                                • BAO66548.1
                                                                                		 104317 - 105777 (-) purine cytosine permease
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                                                                                  Biosynthesis information

                                                                                  No biosynthesis information available for this record.

                                                                                  Annotation changelog

                                                                                  Entry version: 4

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Update chemical activity to schema version 2.11
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 3

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Updated bioactivity data
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2019-10-16
                                                                                  Migrated from v1.4
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2019-10-16
                                                                                  Updated compound(s) information (NPAtlas curation)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2015-06-12
                                                                                  Submitted
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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