LOCUS       BGC0000043             13300 bp    DNA     linear   BCT 12-FEB-2014
DEFINITION  Moorea producens 19L curacin A biosynthetic gene cluster, partial
            sequence.
ACCESSION   BGC0000043
VERSION     BGC0000043
KEYWORDS    .
SOURCE      Moorena producens 19L
  ORGANISM  Moorena producens 19L
            Bacteria; Cyanobacteriota; Cyanophyceae; Oscillatoriophycideae;
            Oscillatoriales; Oscillatoriaceae; Moorena.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 12:38:42
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..6636
                     /gene="curM"
     CDS             1..6636
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (38-454). E-value:
                     2.2e-178. Score: 585.4. Matches aSDomain:
                     nrpspksdomains_curM_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (566-866). E-value: 5e-115.
                     Score: 375.8. Matches aSDomain:
                     nrpspksdomains_curM_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1237-1416). E-value: 3.8e-71.
                     Score: 230.7. Matches aSDomain:
                     nrpspksdomains_curM_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (1523-1588). E-value: 3e-16. Score:
                     51.4. Matches aSDomain: nrpspksdomains_curM_ACP.1"
                     /NRPS_PKS="Domain: Thioesterase (1988-2195). E-value:
                     4.6e-09. Score: 28.9. Matches aSDomain:
                     nrpspksdomains_curM_Thioesterase.1"
                     /codon_start=1
                     /gene="curM"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 257; E-value:
                     5.5e-78)"
                     /gene_kind="biosynthetic"
                     /product="polyketide synthase"
                     /protein_id="ACV42478.1"
                     /sec_met_domain="hyb_KS (E-value: 2.1e-197, bitscore:
                     644.2, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 3.6e-116, bitscore:
                     375.8, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 1.2e-65, bitscore:
                     208.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.6e-15, bitscore:
                     45.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.2e-28, bitscore: 88.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVSKTTQQDVSSQEVLQVLQEMRSRLEAVNKAKTEPIAIVGMA
                     CRFPGGANDPSTYWRLLHDGIDAITPVPPHRWDVNAHYEPNPEIPGKAYTKQGGFIEQV
                     DQFDPLFFGISPREAISLDPQYRLLLEVTWEALENAGQTWTNLKNSKTSVFMGVSTDDY
                     ASLSNPILINNRSLGVGRISHLLGLQGSNIQLDTACSSSLVAIHLACQSLRSGESNLAL
                     VGGVNLILSPISTIGRCTMKALSPDGRCKTFDAAANGYGQAEGCGVVVLKRLSDAITDG
                     DLISALIRGSAINHDGPSSGLTVPNGMAQKQVIQQALSNARLEPHQVSYLEAHGTGTAL
                     GDPIEIEALAAIYGKNRPVDQPLVVGSVKTNIGHLEAAAGVSALIKVVLALQHQEIPPH
                     LHLKQPNPYVDWDKLPIKIPTSLMPWNCEAKPRIAGISSFGISGTNAHLLLEEVPELIK
                     GQKAKGKSENDLERPLHILTLSTKTEKALEELVSRYQNHWETYPELAISDVCYTANTGR
                     AQFNHRLAVIASGSEELTQKLRQHTAGEEVVGVFSGKVPNSGSESKVAFLFTGQGSQYL
                     NMGRQLYETQPTFRQALDTCDHILRPYLDNPLLEILYPQDAQKSNDSPLDQTGYTQPAL
                     FSIEYALLKLWESWGIKPNVVMGHSVGEYVAATVAGVFSLEDGLKLIAARGRLMQGLPA
                     GGEMVSVMASESKVLETLKAMSLEDKVAIAAINGPESIVISGEAEAIRAMATHLESVGI
                     KTKQLQVSHAFHSPLMEPMLAEFEAVANQITYHQPRIPIISNVTGTKADKSIATAQYWV
                     NHVRQPVRFAQGMATLHQQGYETFLEIGAKPILLGMGKQCLSPDVGVWLPSLRHGVDEW
                     QQILSSLGQLYVQGAKVDWSGFDRDYSREKVVLPTYPFQRERYWVETSINQQQVVCSGE
                     PNLQGTPEGTSTTIVKLLSQGNTKELAEKVEKTSDLPPEQLKLLPDLLASLSQQHQQEL
                     ARLTTKKWFYKVQWISQAIKPQRNKSNNQVCHWLILTDSKGLGKSLATHLQQLGNECSV
                     VYQADNYQNYEPGIYHINPSHPQEFEQVYQTIFENGKLPLQKVIHLWSLDTASEQDLTT
                     ETLEQAQLWGCGSTLHLLQTLVKNPNSTPPKLWMITRGTQPVLSPTEKLTVATSPLWGL
                     GRTIASEHPQLWGGLVDLDPQGSEDEVEVLLQQIIDSQKEDHLAVRNRKIYVARLLKHI
                     PQESQPLSLRSDATYLITGGLGALGLKTAAWMAEKGARNLVLISRRQPSEQAQQTIQSL
                     EELGTQVKVLSADISVESDVANILEQIQTSLPPLLGVIHAAGVLDDGLLQQTNWERFTK
                     VMAPKVNGTWNLHKLTQHLSLDFFVCFSSMSSLLGSPGQGNYAAANAFMDAVVHYRREM
                     GLPGLSINWGGWSEGGMATRLASQHQNRMQTAGISLISPEQGIQVLEELVRTQSTAQVG
                     VLPVDWSVLAKQFSSANPSSLLLELLQQETSSEKTDERILEKLQAAPITERQDILKNYI
                     QLVVAKTLGINPSKISTDDNFVELGMDSLMGMEVVNKLSGDLDFIIYPREFYERPTIDS
                     LTQYLSAELSEDNLATQPSPTSLEIFATKSSPSGNSARPASVSSRLPGIIFILSSPRSG
                     STLLRVMLAGHSSLFSPPELHLLPFNTMKERQEQLNLSYLGEGLQKTFMEVKNLDATAS
                     QALIKDLESQNLSIQQVYGMLQENIAPRLLVDKSPTYAMEPTILERGEALFANSKYIYL
                     VRHPYSVIESFVRMRMQKLVGLGEENPYRVAEQVWAKSNQNILNFLSQLEPERQHQIRY
                     EDLVKKPQQVLSQLCDFLNVPFEPELLQPYQGDRMTGGVHQKSLSISDPNFLKHNTIDE
                     SLADKWKTIQLPYPLKSETQRIASQLSYELPNLVTTPTNQQPQVSTTPSTEQPIMEEKF
                     LEFGGNQICLCSWGSPEHPVVLCIHGILEQGLAWQEVALPLAAQGYRVVAPDLFGHGRS
                     SHLEMVTSYSSLTFLAQIDRVIQELPDQPLLLVGHSMGAMLATAIASVRPKKIKELILV
                     ELPLPAEESKKESAVNQLTTCLDYLSSTPQHPIFPDVATAASRLRQAIPSLSEEFSYIL
                     AQRITQPNQGGVRWSWDAIIRTRSILGLNNLPGGRSQYLEMLKSIQVPTTLVYGDSSKL
                     NRPEDLQQQKMTMTQAKRVFLSGGHNLHIDAAAALASLILTS"
     source          1..13300
                     /db_xref="taxon:276768"
                     /mol_type="genomic DNA"
                     /organism="Moorena producens 19L"
                     /strain="19L"
     misc_feature    <1..13300
                     /note="curacin A biosynthetic gene cluster"
     protocluster    1..13300
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[0:6636]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..6636
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     cand_cluster    1..13300
                     /SMILES="CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13300
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000043"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13300
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        115..1362
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_curM_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="2.20E-178"
                     /label="curM_PKS_KS.1"
                     /locus_tag="curM"
                     /protein_end="454"
                     /protein_start="38"
                     /score="585.4"
                     /tool="antismash"
                     /translation="IAIVGMACRFPGGANDPSTYWRLLHDGIDAITPVPPHRWDVNAHY
                     EPNPEIPGKAYTKQGGFIEQVDQFDPLFFGISPREAISLDPQYRLLLEVTWEALENAGQ
                     TWTNLKNSKTSVFMGVSTDDYASLSNPILINNRSLGVGRISHLLGLQGSNIQLDTACSS
                     SLVAIHLACQSLRSGESNLALVGGVNLILSPISTIGRCTMKALSPDGRCKTFDAAANGY
                     GQAEGCGVVVLKRLSDAITDGDLISALIRGSAINHDGPSSGLTVPNGMAQKQVIQQALS
                     NARLEPHQVSYLEAHGTGTALGDPIEIEALAAIYGKNRPVDQPLVVGSVKTNIGHLEAA
                     AGVSALIKVVLALQHQEIPPHLHLKQPNPYVDWDKLPIKIPTSLMPWNCEAKPRIAGIS
                     SFGISGTNAHLLLEEVP"
     aSModule        115..6585
                     /complete
                     /domains="nrpspksdomains_curM_PKS_KS.1"
                     /domains="nrpspksdomains_curM_PKS_AT.1"
                     /domains="nrpspksdomains_curM_PKS_KR.1"
                     /domains="nrpspksdomains_curM_ACP.1"
                     /domains="nrpspksdomains_curM_Thioesterase.1"
                     /final_module
                     /locus_tags="curM"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       568..615
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KS_m3"
                     /locus_tag="curM"
                     /protein_end="205"
                     /protein_start="189"
                     /score="13.9"
                     /tool="antismash"
                     /translation="GSNIQLDTACSSSLVA"
     CDS_motif       988..1035
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0002"
                     /evalue="4.60E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="curM"
                     /protein_end="345"
                     /protein_start="329"
                     /score="12.4"
                     /tool="antismash"
                     /translation="YLEAHGTGTALGDPIE"
     CDS_motif       1096..1140
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0003"
                     /evalue="4.00E-04"
                     /label="PKSI-KS_m6"
                     /locus_tag="curM"
                     /protein_end="380"
                     /protein_start="365"
                     /score="12.7"
                     /tool="antismash"
                     /translation="GSVKTNIGHLEAAAG"
     aSDomain        1699..2598
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_curM_PKS_AT.1"
                     /evalue="5.00E-115"
                     /label="curM_PKS_AT.1"
                     /locus_tag="curM"
                     /protein_end="866"
                     /protein_start="566"
                     /score="375.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFTGQGSQYLNMGRQLYETQPTFRQALDTCDHILRPYLDNPLLEI
                     LYPQDAQKSNDSPLDQTGYTQPALFSIEYALLKLWESWGIKPNVVMGHSVGEYVAATVA
                     GVFSLEDGLKLIAARGRLMQGLPAGGEMVSVMASESKVLETLKAMSLEDKVAIAAINGP
                     ESIVISGEAEAIRAMATHLESVGIKTKQLQVSHAFHSPLMEPMLAEFEAVANQITYHQP
                     RIPIISNVTGTKADKSIATAQYWVNHVRQPVRFAQGMATLHQQGYETFLEIGAKPILLG
                     MGKQCLSPDVGVWLPSLRH"
     CDS_motif       1702..1749
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0004"
                     /evalue="3.20E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="curM"
                     /protein_end="583"
                     /protein_start="567"
                     /score="19.5"
                     /tool="antismash"
                     /translation="FTGQGSQYLNMGRQLY"
     CDS_motif       1879..1944
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0005"
                     /evalue="2.50E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="curM"
                     /protein_end="648"
                     /protein_start="626"
                     /score="11.2"
                     /tool="antismash"
                     /translation="QTGYTQPALFSIEYALLKLWES"
     CDS_motif       1948..2070
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0006"
                     /evalue="1.30E-28"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="curM"
                     /protein_end="690"
                     /protein_start="649"
                     /score="91.4"
                     /tool="antismash"
                     /translation="GIKPNVVMGHSVGEYVAATVAGVFSLEDGLKLIAARGRLMQ"
     CDS_motif       2170..2208
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0007"
                     /evalue="3.40E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="curM"
                     /protein_end="736"
                     /protein_start="723"
                     /score="13.8"
                     /tool="antismash"
                     /translation="AAINGPESIVISG"
     CDS_motif       2428..2463
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0008"
                     /evalue="4.00E-05"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="curM"
                     /protein_end="821"
                     /protein_start="809"
                     /score="16.9"
                     /tool="antismash"
                     /translation="YWVNHVRQPVRF"
     aSDomain        3712..4248
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_curM_PKS_KR.1"
                     /evalue="3.80E-71"
                     /label="curM_PKS_KR.1"
                     /locus_tag="curM"
                     /protein_end="1416"
                     /protein_start="1237"
                     /score="230.7"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: B1"
                     /tool="antismash"
                     /translation="ATYLITGGLGALGLKTAAWMAEKGARNLVLISRRQPSEQAQQTIQ
                     SLEELGTQVKVLSADISVESDVANILEQIQTSLPPLLGVIHAAGVLDDGLLQQTNWERF
                     TKVMAPKVNGTWNLHKLTQHLSLDFFVCFSSMSSLLGSPGQGNYAAANAFMDAVVHYRR
                     EMGLPGLSINWGGWSE"
     CDS_motif       3715..3813
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0009"
                     /evalue="7.70E-18"
                     /label="PKSI-KR_m1"
                     /locus_tag="curM"
                     /protein_end="1271"
                     /protein_start="1238"
                     /score="57.0"
                     /tool="antismash"
                     /translation="TYLITGGLGALGLKTAAWMAEKGARNLVLISRR"
     CDS_motif       4039..4068
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0010"
                     /evalue="1.10E-03"
                     /label="PKSI-KR_m3"
                     /locus_tag="curM"
                     /protein_end="1356"
                     /protein_start="1346"
                     /score="12.3"
                     /tool="antismash"
                     /translation="PKVNGTWNLH"
     CDS_motif       4090..4200
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0011"
                     /evalue="8.10E-24"
                     /label="PKSI-KR_m4"
                     /locus_tag="curM"
                     /protein_end="1400"
                     /protein_start="1363"
                     /score="76.3"
                     /tool="antismash"
                     /translation="LDFFVCFSSMSSLLGSPGQGNYAAANAFMDAVVHYRR"
     aSDomain        4570..4764
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_curM_ACP.1"
                     /evalue="3.00E-16"
                     /label="curM_ACP.1"
                     /locus_tag="curM"
                     /protein_end="1588"
                     /protein_start="1523"
                     /score="51.4"
                     /tool="antismash"
                     /translation="VAKTLGINPSKISTDDNFVELGMDSLMGMEVVNKLSGDLDFIIYP
                     REFYERPTIDSLTQYLSAEL"
     aSDomain        5965..6585
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_curM_Thioesterase.1"
                     /evalue="4.60E-09"
                     /label="curM_Thioesterase.1"
                     /locus_tag="curM"
                     /protein_end="2195"
                     /protein_start="1988"
                     /score="28.9"
                     /tool="antismash"
                     /translation="HGRSSHLEMVTSYSSLTFLAQIDRVIQELPDQPLLLVGHSMGAML
                     ATAIASVRPKKIKELILVELPLPAEESKKESAVNQLTTCLDYLSSTPQHPIFPDVATAA
                     SRLRQAIPSLSEEFSYILAQRITQPNQGGVRWSWDAIIRTRSILGLNNLPGGRSQYLEM
                     LKSIQVPTTLVYGDSSKLNRPEDLQQQKMTMTQAKRVFLSGGHN"
     CDS_motif       6052..6114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_curM_0012"
                     /evalue="2.20E-06"
                     /label="NRPS-te1"
                     /locus_tag="curM"
                     /protein_end="2038"
                     /protein_start="2017"
                     /score="20.2"
                     /tool="antismash"
                     /translation="PDQPLLLVGHSMGAMLATAIA"
     CDS             7051..8061
                     /codon_start=1
                     /product="hypothetical protein"
                     /protein_id="ACV42479.1"
                     /transl_table=11
                     /translation="METKEKFLFFQLWWEIPLALLSLIFYKAVKGLIPILFQKKTKTKK
                     KIADLTKKEVYKWRFVSEELLKQPLVLSYILTTGPRWNVHAIIATTEPVPVKESLKIDI
                     SSCVASAQSWSIGIYSFPEGKPVKYIASHEPKFHKQWQEIKLEPGKYNLALRYYNWYDQ
                     VSLPAVIMDNNQIINTESVNSSQINNYFNYLPKLIGQDNIFYRFLNYYIFTILVCQKWL
                     PKEWVRKEFLPVGDPNNEFVYGVIYKGYYLALTLNPLLLTNYDVYLTTYNRSSLPINFC
                     QINTDKYTTSVIETDGFYLVRLRPKSDLDNNLFQLNWISTELVSEVSCNRSGGEV"
     CDS             8510..9577
                     /codon_start=1
                     /product="putative tRNA 2-selenouridine synthase"
                     /protein_id="ACV42480.1"
                     /transl_table=11
                     /translation="MQRSHNYTQQPKEEDYSEIIDVRSPSEFAEDHMPGAINLPVLDDQ
                     QRAKVGTIYKQVSSFEARKIGASLVAGNISRHLESHFAAKDKNYHPLVYCWRGGKRSQS
                     LAAVLVQIGWQVTVLDGGYKTYRAYVREQLEQLPQQFTYRVLCGLTGSGKTLILRQLAK
                     EGVQVLDLEELANHRGSLLGQEWEGEPLSQPSQKWFESLLLEKLQHFDVHKPVWVEAES
                     NKIGQIYLPHAVWQNMKDASCVEVELPLARRIEWLLQEYPHLGTNPEFCKAKLECLRSR
                     YGWKKINQWYGMIDRGQGDALVGDLLETHYDPAYRRSISKCYGNVVSTLPIVDLSDQSV
                     HNFVKSLVSLTELCC"
     CDS             complement(9627..13097)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 241.3; E-value: 4.6e-73)"
                     /gene_kind="regulatory"
                     /product="putative adenylate/guanylate cyclase"
                     /protein_id="ACV42481.1"
                     /transl_table=11
                     /translation="MLFKSLAQGVSKVSGKVPLPLILVIPFVLQIFAAVGLVAYLSYRN
                     GKRAVNDVATQLLEEVNARVEQNLEAYLTIPDLVNQINATAINLGQLNWQDIPELERYF
                     WQQLQIFNTLTFTGLGLENKDNLGAERLDDGTLTLRVSTTASNQIFYSYSTNEFGERCS
                     RPKGEIPMSDCIKKREEILDSIKFDPRTRPWYNTAVKAGRSTWSEIYPNTAGVTAYLGA
                     SMPFYDTQDQLQGVLLTNINLSQIGNFLSSLNVGQTGQVFIIERSGMIVATSTGEKPFR
                     TTHKDYGAERFKATDSSNPFTKATAQYLSTKLNQKQPIQRLQQWEFAVDGKRKFVQIQP
                     FQDQFDLDWLIVVVVPEGDFIEQIHAHTRTTIALCLVALLLATEVGIVTSRWVVRPILQ
                     LKDAAIALEKGQFDQIVNQERSDELGVLVKAFNNMARQLQESFATLEAKNTELQHLDQL
                     KNEFLANTSHELRTPLNGMISIAESLMDGVAGQLPSKANANLAIIASSGKRLGNLVNDL
                     LDFSKLKHKHLELQIKPVSLREIANLILGHSQSLIGKKPLQLINSIAADMPLVDADENR
                     LQQIIYNLIENAIKFTESGKVEVSAEQLPVSNDELPMLVITVSDTGIGIPADKLNRIFD
                     SFESVDCSRTKEYGGRGLGLAVTRQLVELHGGKIHVRSLRLGEAQCCLGGSPKRSQNKS
                     GSQFTFTLPVCQRPVQQTSAMLPIESIAPVPDLTNETPNFTGVLAADSGYIKILIVDDE
                     PVNRQVISNYLSMENYAIATATNGLEALEMLSTGFQPDLILLDVMMPRMTGYEVCAKIR
                     QKFLPSELPVIMLTANNQISDLVEGFTFGVNDYLTKPCSKHELLARIKSHLRLSKITSA
                     YGKFVPHDFLRFLGYESIVDVKLGDHVQKEMTVLFADIRSFTSLSEQLSPQENFNFINS
                     YLSRVSPAIRAHNGFIDKYIGDGVMALFPESADDGVQGALEMQQTVALYNQHRCKSGYL
                     PITIGIGLHTGSLMLGTIGEQKRMESTVISDAVNLASRLEGLTKLYGAGIMISQQTLYN
                     LNEFQKYSYRFLDRVKVKGKNQPVAVFELFDQDQPQLKQLKRQTKSNFEQAAFLYHRQA
                     FAQAEQIFQSVLQTNPQDKAAMLYVKRCQRYQTYGVPEDWERAEVLHES"
ORIGIN
        1 atgagcaatg tttctaaaac aacccaacaa gatgtatcct ctcaagaggt gcttcaagta
       61 ttacaagaaa tgcggagtag gcttgaagca gtcaacaaag caaaaactga accaatcgct
      121 attgtgggca tggcctgtcg gtttcctggt ggagctaatg acccatctac atattggcgc
      181 ttattacatg atggaataga tgctattaca ccagtaccac ctcaccgttg ggatgttaat
      241 gctcattacg agcctaaccc agaaattcca ggaaaagcct acaccaaaca gggtggattt
      301 attgagcaag ttgaccagtt cgaccctttg ttttttggta tttctcctcg ggaggcaatt
      361 agtttagatc ctcagtacag actactttta gaagttacct gggaagctct ggaaaatgct
      421 gggcaaacat ggactaacct taagaatagt aaaacaagtg tattcatggg cgtctccacg
      481 gatgactatg cgagtctgag taatcctatt cttattaata atcgaagtct tggtgtaggt
      541 cgtatttctc atttacttgg tttacaaggg tctaatatac agttagatac agcttgttca
      601 agttctttag ttgcgatcca tctagcttgt caaagtttgc gatcaggaga atctaattta
      661 gcattagtag gtggagtgaa tttaatctta tcaccaatca gtactattgg ccgctgtaca
      721 atgaaagcac tatcccctga tggtcgctgc aagacttttg atgctgcggc taacggttat
      781 ggtcaggcag aaggatgtgg tgttgtcgtt ttgaagcgtt tgtccgatgc aattactgat
      841 ggtgatttaa tttcagcact tatccgaggt tctgcaatca atcacgatgg acctagtagc
      901 ggtcttacag ttcctaatgg aatggcccag aaacaagtga ttcaacaagc cttgagcaat
      961 gctaggttag aaccccatca ggtgagctat ttggaagctc atgggacagg aactgcttta
     1021 ggagacccca tcgaaataga agctttggcc gcaatatatg gcaaaaatcg tccagtggat
     1081 cagcctttag tagttggttc cgtgaagact aatattggac acttagaggc agccgcaggt
     1141 gtatcagctt taattaaggt cgttttagca cttcagcatc aagaaattcc acctcattta
     1201 cacttaaagc agcctaatcc ctatgtagat tgggataaat taccaattaa aataccaact
     1261 tcattaatgc cttggaattg tgaagccaaa ccgagaatag cagggattag ttcttttggt
     1321 ataagtggca ctaatgctca tttactcttg gaagaggttc ctgagctaat caagggtcaa
     1381 aaggcaaaag gaaaaagtga aaatgactta gaacgtcccc tccatatact aaccctgtca
     1441 accaagacag aaaaagcgct cgaagagtta gtcagtcgtt atcaaaacca ttgggaaact
     1501 tatccagaat tggctatctc agatgtctgt tacacagcta acacaggacg tgcccagttt
     1561 aaccatcgcc tagccgttat tgcctctggc tcagaggaat taacacaaaa acttcggcaa
     1621 cacacagcag gggaagaagt agttggagtt ttttctggca aagtacccaa tagtggcagt
     1681 gagagcaaag tagctttctt atttacaggt cagggttccc agtatttgaa tatgggaagg
     1741 caattgtatg aaactcaacc tacttttcgt caagctttag atacatgtga ccatatcctg
     1801 cgtccttacc tggacaatcc actcctagaa attctatacc ctcaagatgc acaaaagtca
     1861 aatgattctc cactagatca aactggttac acccaaccag ctctgttctc tattgaatac
     1921 gctttgctga agttatggga atcttggggt attaagccaa atgtcgtgat gggtcacagt
     1981 gtgggagaat atgtagcagc aacagtagca ggagtattta gtttagaaga tggcttgaaa
     2041 ctaattgccg ctagaggaag gttaatgcaa ggattacctg ctggtggaga gatggtttca
     2101 gttatggctt cagagtccaa ggttctagag actctgaagg caatgtccct agaagacaaa
     2161 gtagcaatag cagccatcaa tggacccgaa agcatagtca tttccggtga agctgaagcc
     2221 attagagcga tggcaactca cctcgaatca gtaggcatca aaaccaaaca gctacaagta
     2281 tcccatgctt tccattcacc cttgatggaa cccatgttgg cagagtttga agctgtagcc
     2341 aatcaaatca cctaccatca acccaggatt cccatcatat ctaacgtcac aggcacaaaa
     2401 gcagacaaga gcatagccac agcccaatat tgggtcaatc atgtgcgcca accggtaagg
     2461 tttgcccaag gtatggcaac cttgcaccaa caaggctatg aaactttcct agaaattgga
     2521 gccaaaccaa tattattagg tatgggcaag caatgtctat cgccagacgt tggtgtgtgg
     2581 ctgccatctt tgcgtcatgg agtggatgaa tggcaacaga ttctttcaag tttaggacag
     2641 ttatatgtac agggagccaa agtagattgg tcaggatttg atcgagatta tagccgtgag
     2701 aaagtagtat tgccaactta cccattccaa cgagaacggt attgggtaga aactagtata
     2761 aatcaacaac aagttgtatg ctctggggag ccaaacctcc aaggtactcc tgaaggtacg
     2821 agtactacta tcgttaaatt actcagccaa ggaaatacta aagagttagc agaaaaagtc
     2881 gaaaaaacta gtgatttacc accggaacag ttgaaattat taccggattt attagcctca
     2941 ttatctcaac aacatcaaca agaattagcc agattaacta ccaaaaaatg gttttataaa
     3001 gtccagtgga tatctcaagc tataaaaccc caacgaaaca aatcaaataa tcaagtctgt
     3061 cattggttga ttttgacaga ttcaaaagga ttgggcaaat ctttggccac tcatttgcaa
     3121 cagctgggaa atgaatgcag tgtagtttat caagctgata attatcaaaa ttatgaacca
     3181 gggatttatc acattaatcc atctcatccc caggaatttg aacaagtata tcaaacaata
     3241 ttcgaaaacg gtaaattacc cttacaaaag gtaattcatc tgtggagttt ggatactgct
     3301 tctgaacaag atttaaccac cgaaacctta gaacaagcgc aactatgggg atgtggcagt
     3361 acactgcact tattacaaac tttagtcaaa aaccccaact caacaccacc aaaactctgg
     3421 atgatcacca gagggactca acctgtattg tcaccaacag agaaactaac agtggcaaca
     3481 tcaccattgt ggggattagg tagaacgatc gcttctgaac atccgcagct ttggggaggt
     3541 ttggtagatc tcgatccaca gggttccgaa gatgaggtgg aagtactatt acaacagata
     3601 atagatagtc aaaaagaaga ccatctagcg gtgcgcaatc gcaaaatata cgttgctcgt
     3661 ttactcaagc acattcccca agaatctcaa cccctgtcac tgcgatctga tgccacatac
     3721 ctaattactg gaggattagg agccctgggg ttgaagacag cagcatggat ggcagaaaaa
     3781 ggagctagaa atttagtttt aatcagtcgt cgtcaaccct ctgagcaagc acaacaaacg
     3841 attcaaagtt tggaagaatt aggcactcaa gtaaaagttc tttcagcaga tatatcagtt
     3901 gaatccgatg tcgccaatat cctagagcaa attcaaacat ctctaccccc actactaggt
     3961 gtaattcatg cagcaggcgt tttggatgat ggcctactgc aacaaaccaa ttgggagcgc
     4021 tttacgaaag tgatggcccc caaagtcaac gggacttgga atctacataa attaacccag
     4081 catttatccc tagatttctt tgtttgcttc tcatctatga gttccttatt aggttcaccc
     4141 ggtcaaggaa actatgctgc agctaatgct tttatggatg ctgtagttca ttatcgtagg
     4201 gagatgggat taccaggatt aagtattaac tggggaggct ggtctgaagg tggtatggcg
     4261 actcgtcttg caagtcagca tcaaaatcga atgcaaacgg cagggataag tttgatttct
     4321 ccagagcaag gaatacaagt attagaggaa cttgtacgca ctcagtctac agcacaggtg
     4381 ggagtattgc ctgtagattg gtcggtattg gcaaaacaat ttagttcggc aaatccaagt
     4441 tctttactat tagaactctt gcaacaggag acaagctcag aaaagacaga cgaacgcatt
     4501 ttagaaaaat tgcaagctgc accaataact gaacgtcaag atattttgaa aaattatatt
     4561 caattggtag tagcaaaaac tctcggaatc aatccatcaa aaatttccac tgatgacaat
     4621 tttgtagagt tgggtatgga ttccctaatg ggaatggaag ttgtcaataa acttagtggc
     4681 gacctagatt ttattatcta tcccagagag ttttacgaac gaccaacaat cgactccctg
     4741 actcaatatt tgagtgctga gttgagtgaa gataatcttg ctactcaacc atctccaaca
     4801 agcttagaaa tctttgcaac caaaagttca cctagtggaa actctgcacg tccagcctcc
     4861 gtctcttcac gtcttcctgg tattattttt atcctttcga gtccccgctc aggttcaact
     4921 ttactcagag tcatgctagc gggtcattct tccctgtttt caccaccgga gttgcatctg
     4981 ttacccttta acaccatgaa ggagcgacag gagcaactaa acctttctta cttgggggaa
     5041 gggctacaaa aaactttcat ggaagtaaaa aacctggatg caacagctag tcaggctcta
     5101 attaaagacc tcgagtcaca gaacttatca attcagcagg tatatgggat gctccaggag
     5161 aacatagcac ctcgtctact cgtagacaag tctcctactt atgctatgga gcccactatc
     5221 ctagaacgag gggaagcact ctttgctaac tccaaataca tttatctagt tcgtcatccc
     5281 tactcagtca tagaatcatt tgtgcggatg cggatgcaaa aacttgtcgg gttaggtgag
     5341 gaaaatcctt accgggtagc ggagcaggtg tgggctaaga gtaaccagaa cattctaaat
     5401 ttcctgagcc agttggagcc agagcgtcag catcagattc gctatgaaga cttggtgaaa
     5461 aaacctcaac aagtgctatc ccaactatgc gactttctca atgttccctt cgagccagaa
     5521 cttttgcaac cttatcaggg cgatcgcatg acagggggtg ttcatcaaaa gtcattgtca
     5581 atcagtgacc ctaacttcct caaacacaat actattgatg agagcttggc agacaaatgg
     5641 aaaacgattc aattacctta tccgttgaag tcagaaactc aacggatagc cagccaactt
     5701 agttatgagt tgccaaacct agttacaact ccgacaaatc aacagcctca agtctctaca
     5761 actccctcaa cagagcagcc tattatggag gaaaaattcc tggagttcgg aggaaatcag
     5821 atctgtctgt gtagttgggg ttccccggag catcctgtag ttctgtgtat tcatggaatt
     5881 ttggaacaag gattagcttg gcaagaagtc gcacttcctc tagcagcaca aggttatcgg
     5941 gtagtggctc ctgacttatt tggtcacggg cgctcttctc atttggaaat ggtgacttct
     6001 tatagttcac tgacattttt agctcagata gaccgggtaa ttcaggaatt accagaccaa
     6061 cctttgttgt tagtaggtca ttccatgggt gccatgctgg caactgcgat cgctagcgtg
     6121 cgaccaaaga aaatcaaaga gttgattttg gtagaacttc cgctacctgc tgaggaaagc
     6181 aagaaagaat ccgcagttaa tcagctaacg acttgtttag actatctcag ttctactcct
     6241 caacatccca tctttcctga tgtggcaact gctgcaagta ggttgcgtca agcgatacct
     6301 agtctgtcag aagaattttc ttatatctta gctcagcgaa ttacacaacc aaatcaaggt
     6361 ggagttcgct ggagttggga tgcaattatt cgtactcgtt ctattctggg tttaaacaat
     6421 ttacctggtg gtcgatctca atatttggag atgctcaaat ctatccaagt tccgactacg
     6481 ttagtttatg gagatagtag caaactaaat cgaccagaag atttgcaaca acagaaaatg
     6541 actatgactc aagctaaacg agtttttctg tcaggagggc ataatcttca tattgatgct
     6601 gctgctgctt tagcatcact tatcttaaca tcctgagggg gtgacatgag ccccaaaaag
     6661 cttactatat aaggttttga tgccaatggg ctcatggaag atacagtccc aaattgaccc
     6721 tacgaatgat tttatggcaa gctcaaaccc ttataaatac gtccaaagtc agcccaaaac
     6781 agaatgtatc ttttggaaaa ttatgggctg aaatgattac tcagtaagga tttcagcttg
     6841 catgtcaccc ccccagctta acatcacaat aagcaggtgc acaaaattaa ttacccattt
     6901 tcaaaaaatc aaagccttac actgtaaggg ttacagagat tggtagtagt aaattaattt
     6961 tgtttaggtg cttaaaacct gttacagtag gctggatgtg gatttcgaca agattcaggt
     7021 acaatactaa ggtatagagg ttatttgata atggaaacta aagaaaaatt tttattcttc
     7081 caactctggt gggaaattcc actagcattg ttatctttga tattttataa agctgttaag
     7141 ggacttatac ccattctttt tcaaaagaaa accaaaacca agaaaaaaat agcagactta
     7201 accaaaaaag aagtttataa atggcgattt gtttctgaag aactgctaaa acagcctctg
     7261 gtactatcct atattttaac tactggtcct cgatggaatg tccacgccat tattgccact
     7321 acagaaccgg ttccagtcaa agaatcatta aaaattgata tcagttcttg tgtggcttca
     7381 gctcagtcat ggagtatagg tatctatagt tttcctgaag gcaaacctgt caaatacata
     7441 gcatctcatg agccaaaatt tcataaacaa tggcaagaaa tcaaactgga accgggaaaa
     7501 tataatttag ctttaagata ttataattgg tacgatcaag tcagtttacc tgctgttatt
     7561 atggataata atcaaattat caatactgaa tcagttaata gtagtcagat taacaattac
     7621 ttcaattatt tgcccaaatt aataggacaa gataatattt tttatcgatt tcttaattac
     7681 tatatattca ctattctagt atgccagaaa tggctaccta aagaatgggt tagaaaagaa
     7741 tttttacctg tgggagaccc caataatgag tttgtctatg gagttattta taaaggttac
     7801 tatttggctc tgacattaaa tccattatta ctcactaatt atgatgttta tttaaccaca
     7861 tacaatcgtt ctagtctacc aattaatttt tgtcaaatta atactgacaa atacacaact
     7921 tctgtgatag aaaccgacgg tttttattta gtgcgattgc gtcctaagtc agatttagac
     7981 aataatttat ttcagctaaa ttggattagt acagagcttg tatcagaagt ttcctgtaac
     8041 cgttcagggg gcgaagtctg atactctaga aggggagcag gtcaaagttg tagaccatat
     8101 taactatagc aatccgatct gattcgtgaa atatagtggc cgaagcgttc ccgtagcgtc
     8161 ggctacgccg aatcgcgata gcctcgactg caccgaatcg ctataaccct tccccagcaa
     8221 aaaattgata ttttgctgat ggaaaaaatg attgaggatt gctataggta ctatcacagc
     8281 aagctaaaac ccatgagggg gctttagttt tagtccaaat tttatgcata agtgacatgc
     8341 tcctaacctg gggtctttta atagggggag atatcatgaa aatgctccta taaagaatta
     8401 gaaaagagta gtaaatttta gctattcatg atacaacaaa attgaattat atagcgtttt
     8461 tcgcagttat gatgtacagt atgtcacgaa acacaaaatt gaacatcgaa tgcagcgatc
     8521 gcataactat acccagcagc caaaggaaga agactacagc gaaattattg atgtgcgctc
     8581 cccgagtgag tttgctgagg atcatatgcc aggtgcgatt aatctacctg tgctcgatga
     8641 tcagcaaagg gctaaggtgg ggactatcta taaacaagtg tcttcctttg aagctcgcaa
     8701 aattggtgcc tctctagttg ctgggaatat ctctcgacat ctggaaagtc actttgctgc
     8761 taaggataaa aattaccatc ccttagtcta ttgttggcgg ggtggaaagc gttcccagag
     8821 tttggcagca gtgttagttc aaattggctg gcaagttaca gttctcgacg ggggatacaa
     8881 aacctatcga gcttatgtaa gggaacaatt agaacagttg ccacaacagt ttacttaccg
     8941 agtattgtgt ggactaaccg gtagtgggaa aaccctgatc ttgcggcaac ttgctaagga
     9001 aggtgttcag gtactggatt tggaagagtt agccaatcat cgaggttccc tgctcggtca
     9061 agagtgggaa ggtgaaccat tatctcaacc atcccaaaaa tggtttgaat ccctgctatt
     9121 ggaaaaattg caacactttg atgtccataa gccagtatgg gtggaagcag aaagcaataa
     9181 gattggacaa atttatttgc ctcatgcagt atggcaaaat atgaaggatg ctagctgtgt
     9241 ggaagttgag ttacccttgg cacgtcgaat tgaatggttg ttgcaagagt atcctcactt
     9301 gggtactaac cctgagtttt gcaaagctaa actagagtgt ctaaggtctc gctatggctg
     9361 gaaaaaaatt aaccagtggt atggaatgat tgataggggt caaggtgatg ctttggtagg
     9421 agatttgctt gaaactcatt atgatccagc ttaccgccgc tcgattagta agtgttatgg
     9481 aaatgtagta tcaaccttac cgattgtgga tttatcagat cagagtgttc ataattttgt
     9541 caaaagtttg gtgtctttga cggaattatg ctgttgaatt attttaccca ctaccataaa
     9601 ttattacaca attgggcaac gccaaattat gactcatgca acacttctgc ccgttcccag
     9661 tcctctggca ccccataggt ttgatacctt tggcagcgtt tgacatagag catcgctgct
     9721 ttatcctggg gattggtttg taaaactgac tgaaatatct gttcagcttg ggcgaaggct
     9781 tgccgatggt agagaaaagc agcttgttca aagttactct tagtttgtct ctttaactgc
     9841 ttcagttgtg gctgatcttg atcaaatagc tcaaatactg ccaccggttg attttttccc
     9901 ttaactttga ctcgatccaa aaacctataa ctgtactttt gaaactcatt caggttatag
     9961 agggtttgtt ggctaatcat aatccctgca ccataaagtt tggttaatcc ttccaagcgg
    10021 gaagcaagat tcactgcatc agaaatcacc gtactttcca tccgcttttg ttcaccgatg
    10081 gttcctagca ttaagctacc tgtatgtaaa ccaataccga tagtaatcgg aagatatcca
    10141 ctcttgcacc gatgctggtt gtagagtgca actgtttgtt gcatctcaag tgcaccttga
    10201 accccatcat ccgctgattc aggaaaaagt gccataactc catctccaat gtacttatca
    10261 ataaagccat tgtgagcgcg aattgctgga ctaactcgac tcagatagct attaataaaa
    10321 ttaaaatttt cttgaggaga taactgttct gataggctgg taaaagagcg aatatcagca
    10381 aaaagaactg tcatttcttt ttgaacatgg tcccctaatt taacatcaac aatactttca
    10441 tatcctagga agcgcaaaaa atcatgggga acaaacttac cataagccga ggtaatttta
    10501 gaaagccgta gatgactttt aattcgggct aacaattcat gtttagaaca aggcttagtc
    10561 agataatcat ttaccccaaa agtaaaccct tctaccaaat cggaaatttg attgttggcg
    10621 gttaacatga tcaccggaag ttcactgggc aaaaacttct ggcgaatttt tgcacagact
    10681 tcatagcccg tcatgcgggg catcatcaca tccagtaaga tcaagtcagg ctggaagcca
    10741 gttgagagca tttctaaagc ttctaaacca ttagtggctg tagcgatcgc atagttttcc
    10801 atggaaagat aattgctaat aacctggcgg ttgactggtt catcgtccac tatcaaaatt
    10861 ttgatatatc cactgtctgc tgctaagact ccagtaaagt tcggggtttc attcgtcaag
    10921 tccggaactg gagcaatgga ttcaattggc aacattgctg aggtctgctg aaccggcctc
    10981 tgacacactg gcaaagtaaa tgtaaactgg gaaccagact tattttgcga tcgcttaggg
    11041 gatcctccca gacagcattg tgcttctccc agcctaagcg atcgcacatg aattttgcca
    11101 ccgtgtaact cgactaactg tctagtaacc gctaatccca aacccctccc gccgtattct
    11161 ttagtcctgg agcaatctac tgattcaaag gagtcaaaaa tccgatttaa tttatctgct
    11221 ggaataccaa ttcctgtatc tgagacagta atgactaaca ttggtaactc gtcattgcta
    11281 acgggtaact gctcagctga tacttcaacc ttaccagatt cagtaaactt aatagcattc
    11341 tcgattaagt tataaataat ttgttgcagc cgattttcgt cagcatcgac caagggcata
    11401 tcggcagcaa ttgagttaat taactgcaaa ggttttttgc caattagaga ctgggaatgc
    11461 ccaaggatga gattggctat ttctcgcagg ctgactggct taatttgaag ttcaagatgt
    11521 ttgtgtttta gcttggaaaa atccaggaga tcgttgacta aattccctag tctttttcca
    11581 ctagatgcaa tgatggcaag attagcgttt gctttggagg gcaattgtcc tgcaacacca
    11641 tccatcaggg attcagcaat gctgatcatg ccattgaggg gagtgcggag ttcgtgggag
    11701 gtattggcta aaaattcgtt tttcagttga tcgaggtgct gcaattcagt attcttggct
    11761 tctagggtgg caaacgactc ttgcaattgt cttgccatgt tattaaatgc cttaaccaaa
    11821 accccaagtt catcggagcg ctcctgattg acaatttggt caaattgtcc cttctctaga
    11881 gcaatggctg catccttcag ttggaggata ggccggacaa cccaacggga tgtaacgatt
    11941 ccgacttctg ttgccagtaa caatgctact aggcataagg caatagtagt gcgggtatgg
    12001 gcgtggattt gttcgatgaa atccccttct ggcacgacta ccacaatcaa ccaatccaag
    12061 tcaaactgat cttgaaaagg ctgtatttgt acaaattttc gtttaccgtc aacagcaaat
    12121 tcccattgct gtaaacgttg aattggttgt ttttgattca gcttggttga taaatactga
    12181 gccgtagctt tagtgaaggg attactacta tccgttgctt taaatcgttc ggctccgtag
    12241 tctttgtgag tagtgcgaaa aggcttctca ccggtagaag tagccacgat cattcccgaa
    12301 cgttcaatga taaaaacttg tccagtttgg ccaacgttta gactgcttaa aaagttgccg
    12361 atttgtgata gatttatatt agttaggagt accccctgca attgatcctg tgtgtcgtaa
    12421 aatggcattg atgcaccgag ataggcagtt acaccagcag tattggggta aatttcactc
    12481 caagttgagc gaccagcttt gacagcagtg ttataccatg gtcgagtgcg cggatcaaac
    12541 ttaatactgt ctaggatttc ctcacgcttc ttgatgcagt cgctcatggg gatttccccc
    12601 tttggccgac tgcatcgctc cccaaattcg ttagtagaat aggagtaaaa aatctgattg
    12661 ctagctgtgg tggatactct aagagtcagt gtaccatcat ctaatcgttc tgctcctagg
    12721 ttgtctttat tctctaagcc taatccagta aatgtgaggg tattaaatat ctgaagctgt
    12781 tgccaaaagt aacgttctaa ttcaggaata tcttgccaat tcaattgacc tagattgatg
    12841 gcagtggcat taatctgatt aactagatca ggaatggtta gataagcctc caaattctgc
    12901 tcaacccgag cattgacttc ttcaagcagt tgagtcgcaa catcattaac cgctctcttg
    12961 ccgtttctat aggacagata tgccacaagt ccgactgctg cgaagatttg caggacaaat
    13021 ggtatgacca agatcagggg aaggggaact ttcccagaaa ccttggaaac cccttgggct
    13081 aaagatttga ataacatttg cctatgccat cctgcttgac tgacaaatcc ttaggagtta
    13141 cattcacaga attcccagaa atctaaaaaa agtagcgtca gcacccttga ctaaagtaaa
    13201 ggggcttaaa gtcctttatt tactgatgcc tgaatcctta gaaaggactt cataaatcgt
    13261 aagcattcag ccgtcagccg tcagccgtca gccgttggcc
//
