BGC0000045 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000045 (Aspergillus terreus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	31,000	High	dehydrocurvularin	PKS

BGC0000045 - Region 1 - T1PKS

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Location: 1 - 31,000 nt. (total: 31,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,001
Label		BGC0000045

Tailoring functions

Ligases: synthase

curS1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

curS2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045.3	1.00	PKS	dehydrocurvularin	Aspergillus terreus
BGC0001246.3	0.68	PKS	trans-resorcylide	Sarocladium zeae
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045.3	1.00	PKS	dehydrocurvularin	Aspergillus terreus
BGC0001246.3	0.68	PKS	trans-resorcylide	Sarocladium zeae
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 31000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: curS1 + curS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

curS2: mal

PKS_AT (896..1189): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 122.7
inactive: 81.1
Methoxymalonyl-CoA: 61.6
Methylmalonyl-CoA: 53.4
Isobutyryl-CoA: 33.7
2-Methylbutyryl-CoA: 23.2
Benzoyl-CoA: 22.6
Propionyl-CoA: 21.0
Acetyl-CoA: 20.9
CHC-CoA: 17.2
Ethylmalonyl-CoA: 15.3
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 12.5
fatty_acid: 0.0

curS1: pk

PKS_AT (551..872): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; 2-Methylbutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 85.7
Methoxymalonyl-CoA: 69.9
Malonyl-CoA: 66.8
Ethylmalonyl-CoA: 49.1
Isobutyryl-CoA: 38.9
Benzoyl-CoA: 38.0
Propionyl-CoA: 36.4
2-Methylbutyryl-CoA: 24.7
fatty_acid: 18.8
CHC-CoA: 18.5
trans-1,2-CPDA: 14.4
Acetyl-CoA: 13.5
3-Methylbutyryl-CoA: 13.2
inactive: 0.0

Link to PARAS substrate predictor