BGC0000045 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000045 (Aspergillus terreus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	31,000	dehydrocurvularin	PKS	100%

BGC0000045 - Region 1 - T1PKS

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Location: 1 - 31,000 nt. (total: 31,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,001
Label		BGC0000045

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045	1.00	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0001246	0.35	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0002301	0.32	Polyketide	(P)-ustilaginoidin A	Aschersonia paraphysata
BGC0001446	0.28	Polyketide	asparasone A	Aspergillus flavus NRRL3357
BGC0001340	0.27	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000030	0.26	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289
BGC0001124	0.24	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001913	0.24	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0000041	0.23	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000056	0.22	Polyketide	esperamicin	Actinomadura verrucosospora

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000045	1.00	Polyketide	dehydrocurvularin	Aspergillus terreus
BGC0001246	0.68	Polyketide	trans-resorcylide	Sarocladium zeae
BGC0002301	0.65	Polyketide	(P)-ustilaginoidin A	Aschersonia paraphysata
BGC0001446	0.62	Polyketide	asparasone A	Aspergillus flavus NRRL3357
BGC0001340	0.60	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0000030	0.60	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289
BGC0001124	0.58	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001913	0.57	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0000041	0.56	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000056	0.55	Polyketide	esperamicin	Actinomadura verrucosospora

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 31000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: curS1 + curS2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

curS2

PKS_AT (896..1189): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 122.7
inactive: 81.1
Methoxymalonyl-CoA: 61.6
Methylmalonyl-CoA: 53.4
Isobutyryl-CoA: 33.7
2-Methylbutyryl-CoA: 23.2
Benzoyl-CoA: 22.6
Propionyl-CoA: 21.0
Acetyl-CoA: 20.9
CHC-CoA: 17.2
Ethylmalonyl-CoA: 15.3
trans-1,2-CPDA: 13.1
3-Methylbutyryl-CoA: 12.5
fatty_acid: 0.0

curS1

PKS_AT (551..872): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; 2-Methylbutyryl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 85.7
Methoxymalonyl-CoA: 69.9
Malonyl-CoA: 66.8
Ethylmalonyl-CoA: 49.1
Isobutyryl-CoA: 38.9
Benzoyl-CoA: 38.0
Propionyl-CoA: 36.4
2-Methylbutyryl-CoA: 24.7
fatty_acid: 18.8
CHC-CoA: 18.5
trans-1,2-CPDA: 14.4
Acetyl-CoA: 13.5
3-Methylbutyryl-CoA: 13.2
inactive: 0.0