BGC0000046 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000046 (Alternaria brassicicola)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	25,000	depudecin	PKS:Iterative type I	100%

BGC0000046 - Region 1 - T1PKS

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Location: 1 - 25,000 nt. (total: 25,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,001
Label		BGC0000046

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000046	1.00	Polyketide	depudecin	Alternaria brassicicola
BGC0001340	0.23	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001124	0.20	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001913	0.20	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0002191	0.19	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254	0.19	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002233	0.18	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002240	0.18	Polyketide	BAB, BAA	Metarhizium anisopliae
BGC0002228	0.17	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001606	0.17	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000046	1.00	Polyketide	depudecin	Alternaria brassicicola
BGC0001340	0.57	Polyketide	byssochlamic acid	Byssochlamys fulva
BGC0001124	0.53	Polyketide	pyranonigrin E	Aspergillus niger ATCC 1015
BGC0001913	0.52	Polyketide	phomoidride	fungal sp. ATCC 74256
BGC0002191	0.51	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254	0.51	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002233	0.50	Polyketide	trichoxide	Trichoderma virens Gv29-8
BGC0002240	0.50	Polyketide	BAB, BAA	Metarhizium anisopliae
BGC0002228	0.49	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001606	0.49	Polyketide	gibepyrone-A	Fusarium fujikuroi IMI 58289

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 25000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

DEP5

PKS_AT (592..905): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 62.5%; Isobutyryl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 65.3
Methoxymalonyl-CoA: 53.6
Malonyl-CoA: 52.2
Propionyl-CoA: 32.7
Isobutyryl-CoA: 22.4
CHC-CoA: 19.5
3-Methylbutyryl-CoA: 18.4
Ethylmalonyl-CoA: 16.0
2-Methylbutyryl-CoA: 13.8
Benzoyl-CoA: 12.6
fatty_acid: 9.3
trans-1,2-CPDA: 0.0
inactive: 0.0
Acetyl-CoA: 0.0