Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000046.1:
Cluster 1Polyketide125000

BGC0000046, depudecin biosynthetic gene cluster from Alternaria brassicicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: depudecin
PubChem ID: 6438725
ChEBI ID: 64143
ChemSpider ID: 21169370
SMILES string: Copy to clipboard
Molecular formula: C11H16O4
Average molecular mass: 212.245 Da
Molecular activity: Inhibitor
Molecular target: Histone deacetylase (HDAC)

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (linear)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ACZ57548.1
Iterative PKS subtype:
Partially reducing
6
Thioesterase type:
None
Release / cyclization type:
Hydrolysis

Gene cluster description

depudecin (BGC0000046). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank FJ977165. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Jonathan Walton (Michigan State University)

Literature references

1. Wight WD et al. (2009) Biosynthesis and role in virulence of the histone deacetylase inhibitor depudecin from Alternaria brassicicola. Mol Plant Microbe Interact 22(10):1258-67. doi: