BGC0000047 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000047 (Streptomyces sp. KCTC 0041BP)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	75,439	High	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	PKS

BGC0000047 - Region 1 - T1PKS

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Location: 1 - 75,439 nt. (total: 75,439 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 75,440
Label		BGC0000047

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

gerKII: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

gerO: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

gerPI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

gerPII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

gerPIII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

gerY: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase aminotransferase glycosyltransferase transferase

gerB: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

gerD: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

gerSV: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

gerTI: glycosyltransferase

smcogs: SMCOG1102: glycosyltransferase

gerTII: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: esterase

gerG: thioesterase

smcogs: SMCOG1004: thioesterase

Lyases: dehydratase

gerE: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

gerKI: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

gerSI: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gerSII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gerSIII: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gerSIV: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000047.5	0.99	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0001396.5	0.87	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000035.5	0.82	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000047.5	1.00	PKS	10,11-dihydro-8-deoxy-12,13-deepoxy-12,13-dihydrochalcomycin	Streptomyces sp. KCTC 0041BP
BGC0001396.5	0.88	PKS	aldgamycin J, aldgamycin K, aldgamycin P, aldgamycin E	Streptomyces sp. A1(2016)
BGC0000035.5	0.79	PKS	chalcomycin A	Streptomyces bikiniensis
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.69	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 7961 - 75439:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - pk) + (ccmal) + (Me-ccmal - Me-redmal) + (Me-ohmal) + (mal)
Non-colinear ordering:: gerSI + gerSII + gerSIII + gerSIV + gerSV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

gerSI: pk - mmal - pk

PKS_AT (523..819): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 181.0
Ethylmalonyl-CoA: 162.7
Methoxymalonyl-CoA: 156.3
CHC-CoA: 104.6
2-Methylbutyryl-CoA: 96.8
trans-1,2-CPDA: 93.9
Malonyl-CoA: 92.9
Propionyl-CoA: 87.3
Isobutyryl-CoA: 77.3
Benzoyl-CoA: 50.3
fatty_acid: 46.5
3-Methylbutyryl-CoA: 30.4
inactive: 28.0
Acetyl-CoA: 27.9

PKS_AT (1536..1831): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.9
Ethylmalonyl-CoA: 190.5
Methoxymalonyl-CoA: 171.8
2-Methylbutyryl-CoA: 123.4
Malonyl-CoA: 108.8
Propionyl-CoA: 106.9
CHC-CoA: 106.1
trans-1,2-CPDA: 102.8
Isobutyryl-CoA: 78.2
fatty_acid: 51.6
Benzoyl-CoA: 49.7
Acetyl-CoA: 47.9
3-Methylbutyryl-CoA: 36.2
inactive: 27.4

PKS_AT (3033..3329): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 181.0
Ethylmalonyl-CoA: 162.7
Methoxymalonyl-CoA: 156.3
CHC-CoA: 104.6
2-Methylbutyryl-CoA: 96.8
trans-1,2-CPDA: 93.9
Malonyl-CoA: 92.9
Propionyl-CoA: 87.3
Isobutyryl-CoA: 77.3
Benzoyl-CoA: 50.3
fatty_acid: 46.5
3-Methylbutyryl-CoA: 30.4
inactive: 28.0
Acetyl-CoA: 27.9

gerSII: mal

PKS_AT (565..860): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.2
inactive: 109.6
Methoxymalonyl-CoA: 71.4
Methylmalonyl-CoA: 68.3
Propionyl-CoA: 50.0
Isobutyryl-CoA: 34.5
Ethylmalonyl-CoA: 28.4
Acetyl-CoA: 26.7
CHC-CoA: 25.5
fatty_acid: 24.8
2-Methylbutyryl-CoA: 22.4
trans-1,2-CPDA: 21.4
Benzoyl-CoA: 13.5
3-Methylbutyryl-CoA: 11.7

gerSIII: mmal - mmal

PKS_AT (551..845): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.6
Ethylmalonyl-CoA: 203.8
Methoxymalonyl-CoA: 178.5
2-Methylbutyryl-CoA: 128.8
Propionyl-CoA: 118.4
Malonyl-CoA: 114.3
CHC-CoA: 114.3
trans-1,2-CPDA: 109.4
Isobutyryl-CoA: 82.1
Benzoyl-CoA: 63.9
fatty_acid: 63.0
Acetyl-CoA: 55.7
3-Methylbutyryl-CoA: 41.1
inactive: 28.0

PKS_AT (2038..2332): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.0
Ethylmalonyl-CoA: 200.5
Methoxymalonyl-CoA: 171.4
2-Methylbutyryl-CoA: 127.7
Malonyl-CoA: 116.8
CHC-CoA: 116.3
trans-1,2-CPDA: 114.2
Propionyl-CoA: 112.1
Isobutyryl-CoA: 83.8
Benzoyl-CoA: 65.1
fatty_acid: 54.7
Acetyl-CoA: 46.7
3-Methylbutyryl-CoA: 36.4
inactive: 28.8

gerSIV: mmal

PKS_AT (565..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.6
Ethylmalonyl-CoA: 198.4
Methoxymalonyl-CoA: 173.0
2-Methylbutyryl-CoA: 128.1
CHC-CoA: 117.8
trans-1,2-CPDA: 114.3
Malonyl-CoA: 113.4
Propionyl-CoA: 112.3
Isobutyryl-CoA: 80.6
Benzoyl-CoA: 59.9
fatty_acid: 58.5
Acetyl-CoA: 51.3
3-Methylbutyryl-CoA: 36.9
inactive: 28.6

gerSV: mal

PKS_AT (578..888): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.2
inactive: 106.1
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 57.5
Propionyl-CoA: 37.7
Isobutyryl-CoA: 22.8
Benzoyl-CoA: 19.7
Acetyl-CoA: 17.5
Ethylmalonyl-CoA: 16.2
2-Methylbutyryl-CoA: 13.5
fatty_acid: 9.4
CHC-CoA: 5.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor