BGC0000050 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000050 (Streptomyces aculeolatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	50,114	E-837	PKS	100%

BGC0000050 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 50,114 nt. (total: 50,114 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,115
Label		BGC0000050

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000050	1.00	Polyketide	E-837	Streptomyces aculeolatus
BGC0001273	0.34	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.33	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001244	0.33	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.32	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0000041	0.32	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002229	0.32	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000050	1.00	Polyketide	E-837	Streptomyces aculeolatus
BGC0001273	0.67	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001163	0.67	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001244	0.66	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001276	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002229	0.65	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 50114:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-ccmal - Me-ohmal) + (ccmal - Me-ccmal) + (redmal) + (ccmal - Me-ohmal) + (Me-ohmal)
Non-colinear ordering:: ABB88519.1 + ABB88520.1 + ABB88521.1 + ABB88522.1 + ABB88523.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ABB88519.1

PKS_AT (552..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 195.3
inactive: 104.2
Methoxymalonyl-CoA: 65.0
Methylmalonyl-CoA: 51.8
Propionyl-CoA: 29.6
Isobutyryl-CoA: 27.9
Ethylmalonyl-CoA: 21.8
Acetyl-CoA: 19.1
CHC-CoA: 17.1
2-Methylbutyryl-CoA: 12.4
Benzoyl-CoA: 10.9
trans-1,2-CPDA: 6.8
3-Methylbutyryl-CoA: 4.9
fatty_acid: 0.0

PKS_AT (1583..1880): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 183.9
Ethylmalonyl-CoA: 179.4
Methoxymalonyl-CoA: 148.5
trans-1,2-CPDA: 108.4
Malonyl-CoA: 103.1
2-Methylbutyryl-CoA: 92.3
Propionyl-CoA: 88.6
CHC-CoA: 74.4
Benzoyl-CoA: 58.5
Isobutyryl-CoA: 55.2
inactive: 29.8
fatty_acid: 29.3
Acetyl-CoA: 28.3
3-Methylbutyryl-CoA: 12.3

PKS_AT (3307..3604): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 185.3
Ethylmalonyl-CoA: 181.3
Methoxymalonyl-CoA: 154.2
trans-1,2-CPDA: 108.6
Malonyl-CoA: 107.7
2-Methylbutyryl-CoA: 101.1
Propionyl-CoA: 92.9
CHC-CoA: 82.8
Isobutyryl-CoA: 56.4
Benzoyl-CoA: 56.0
inactive: 33.8
Acetyl-CoA: 28.5
fatty_acid: 23.2
3-Methylbutyryl-CoA: 11.6

ABB88520.1

PKS_AT (560..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 166.0
inactive: 75.7
Methoxymalonyl-CoA: 53.2
Methylmalonyl-CoA: 35.2
Ethylmalonyl-CoA: 17.9
Acetyl-CoA: 16.0
CHC-CoA: 11.5
fatty_acid: 10.9
trans-1,2-CPDA: 10.7
Isobutyryl-CoA: 10.5
Benzoyl-CoA: 9.8
Propionyl-CoA: 3.5
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2288..2585): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 185.9
Ethylmalonyl-CoA: 181.0
Methoxymalonyl-CoA: 152.7
trans-1,2-CPDA: 111.6
Malonyl-CoA: 110.5
2-Methylbutyryl-CoA: 100.8
Propionyl-CoA: 94.0
CHC-CoA: 81.2
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 55.4
inactive: 33.8
Acetyl-CoA: 28.2
fatty_acid: 20.3
3-Methylbutyryl-CoA: 10.2

ABB88521.1

PKS_AT (571..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.0
inactive: 90.9
Methoxymalonyl-CoA: 66.5
Methylmalonyl-CoA: 49.3
Propionyl-CoA: 25.8
Isobutyryl-CoA: 23.0
Acetyl-CoA: 19.0
fatty_acid: 14.4
Ethylmalonyl-CoA: 12.2
CHC-CoA: 11.9
trans-1,2-CPDA: 11.2
Benzoyl-CoA: 10.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ABB88522.1

PKS_AT (575..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.2
inactive: 83.6
Methoxymalonyl-CoA: 61.2
Methylmalonyl-CoA: 45.8
Isobutyryl-CoA: 17.8
Propionyl-CoA: 15.5
Acetyl-CoA: 14.4
CHC-CoA: 12.1
fatty_acid: 11.1
Benzoyl-CoA: 9.2
Ethylmalonyl-CoA: 3.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (2318..2615): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 185.9
Ethylmalonyl-CoA: 181.0
Methoxymalonyl-CoA: 152.7
trans-1,2-CPDA: 111.6
Malonyl-CoA: 110.5
2-Methylbutyryl-CoA: 100.8
Propionyl-CoA: 94.0
CHC-CoA: 81.2
Isobutyryl-CoA: 56.1
Benzoyl-CoA: 55.4
inactive: 33.8
Acetyl-CoA: 28.2
fatty_acid: 20.3
3-Methylbutyryl-CoA: 10.2

ABB88523.1

PKS_AT (597..895): mmal

ATSignature: Methylmalonyl-CoA, Methoxymalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%; Malonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 158.1
Ethylmalonyl-CoA: 147.7
Methoxymalonyl-CoA: 134.1
Isobutyryl-CoA: 83.9
trans-1,2-CPDA: 81.9
2-Methylbutyryl-CoA: 81.1
Malonyl-CoA: 77.3
Propionyl-CoA: 64.9
CHC-CoA: 56.8
Benzoyl-CoA: 55.4
3-Methylbutyryl-CoA: 40.5
inactive: 21.4
Acetyl-CoA: 17.5
fatty_acid: 6.7