BGC0000054 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000054 (Aeromicrobium erythreum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	61,845	erythromycin	PKS	100%

BGC0000054 - Region 1 - T1PKS

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Location: 1 - 61,845 nt. (total: 61,845 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 61,846
Label		BGC0000054

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000054	0.98	Polyketide	erythromycin	Aeromicrobium erythreum
BGC0000016	0.36	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.35	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001605	0.34	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002347	0.30	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0000265	0.30	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0000278	0.30	Polyketide	urdamycin	Streptomyces fradiae
BGC0000043	0.28	Polyketide	curacin A	Moorea producens 19L
BGC0001163	0.28	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001223	0.28	Other	hydroxysporine	uncultured bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000054	1.00	Polyketide	erythromycin	Aeromicrobium erythreum
BGC0000016	0.69	Other	amphotericin B	Streptomyces nodosus
BGC0000041	0.68	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001605	0.67	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002347	0.64	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0000265	0.63	Polyketide	rhodomycin	Streptomyces purpurascens
BGC0000278	0.63	Polyketide	urdamycin	Streptomyces fradiae
BGC0002246	0.63	Terpene	naematolin	Hypholoma sublateritium FD-334 SS-4
BGC0000043	0.62	Polyketide	curacin A	Moorea producens 19L
BGC0001163	0.61	Polyketide	1-heptadecene	Moorea producens 3L

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 3549 - 61845:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ccmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: eryAI + eryAII + eryAIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

eryAIII

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.9
Ethylmalonyl-CoA: 187.7
2-Methylbutyryl-CoA: 156.9
Methoxymalonyl-CoA: 154.8
trans-1,2-CPDA: 130.1
Propionyl-CoA: 110.4
CHC-CoA: 97.2
Malonyl-CoA: 93.2
Benzoyl-CoA: 84.6
Isobutyryl-CoA: 76.9
3-Methylbutyryl-CoA: 43.3
Acetyl-CoA: 35.8
fatty_acid: 29.7
inactive: 23.7

PKS_AT (2044..2334): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 159.9
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 130.4
Malonyl-CoA: 114.0
trans-1,2-CPDA: 97.7
CHC-CoA: 95.3
Propionyl-CoA: 94.9
Isobutyryl-CoA: 60.3
Benzoyl-CoA: 50.5
inactive: 35.9
Acetyl-CoA: 34.2
3-Methylbutyryl-CoA: 29.9
fatty_acid: 27.0

eryAII

PKS_AT (562..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.8
Ethylmalonyl-CoA: 195.6
Methoxymalonyl-CoA: 165.2
2-Methylbutyryl-CoA: 131.0
trans-1,2-CPDA: 104.0
Malonyl-CoA: 103.1
CHC-CoA: 95.9
Propionyl-CoA: 89.2
Isobutyryl-CoA: 84.0
Benzoyl-CoA: 79.5
3-Methylbutyryl-CoA: 44.2
Acetyl-CoA: 40.0
inactive: 37.6
fatty_acid: 19.8

PKS_AT (2015..2311): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.7
Ethylmalonyl-CoA: 193.7
Methoxymalonyl-CoA: 157.3
2-Methylbutyryl-CoA: 115.4
trans-1,2-CPDA: 113.2
CHC-CoA: 107.1
Malonyl-CoA: 80.8
Propionyl-CoA: 80.3
Benzoyl-CoA: 61.4
Isobutyryl-CoA: 56.1
Acetyl-CoA: 34.7
fatty_acid: 29.2
inactive: 21.9
3-Methylbutyryl-CoA: 16.2

eryAI

PKS_AT (68..363): pk

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; 2-Methylbutyryl-CoA: 70.8%; Methylmalonyl-CoA: 66.7%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 218.7
2-Methylbutyryl-CoA: 139.0
Methylmalonyl-CoA: 118.7
Methoxymalonyl-CoA: 103.9
Ethylmalonyl-CoA: 92.1
Malonyl-CoA: 78.8
trans-1,2-CPDA: 71.3
CHC-CoA: 64.8
Acetyl-CoA: 44.0
fatty_acid: 33.0
Benzoyl-CoA: 28.1
Isobutyryl-CoA: 24.3
inactive: 23.6
3-Methylbutyryl-CoA: 15.4

PKS_AT (1036..1336): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.2
Ethylmalonyl-CoA: 171.6
Methoxymalonyl-CoA: 158.3
2-Methylbutyryl-CoA: 118.7
trans-1,2-CPDA: 95.4
Malonyl-CoA: 85.2
Propionyl-CoA: 85.1
Isobutyryl-CoA: 82.5
CHC-CoA: 81.1
3-Methylbutyryl-CoA: 55.8
Benzoyl-CoA: 44.9
Acetyl-CoA: 39.9
fatty_acid: 27.2
inactive: 21.7

PKS_AT (2512..2806): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 159.9
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 130.4
Malonyl-CoA: 114.0
trans-1,2-CPDA: 97.7
CHC-CoA: 95.3
Propionyl-CoA: 94.9
Isobutyryl-CoA: 60.3
Benzoyl-CoA: 50.5
inactive: 35.9
Acetyl-CoA: 34.2
3-Methylbutyryl-CoA: 29.9
fatty_acid: 27.0