BGC0000055 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000055 (Saccharopolyspora erythraea NRRL 2338)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	54,612	erythromycin A/erythromycin B/erythromycin C/erythromycin D	PKS:Type I+saccharide:hybrid/tailoring	100%

BGC0000055 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 54,612 nt. (total: 54,612 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 54,613
Label		BGC0000055

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000055	1.00	Polyketide, Saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0002084	0.35	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001605	0.34	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002031	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0002406	0.31	Other	hydroxycinnamoyltyramine	Oryza sativa Japonica Group
BGC0000041	0.31	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000278	0.30	Polyketide	urdamycin	Streptomyces fradiae
BGC0002347	0.30	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0000016	0.29	Other	amphotericin B	Streptomyces nodosus
BGC0001163	0.28	Polyketide	1-heptadecene	Moorea producens 3L

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000055	1.00	Polyketide, Saccharide	erythromycin A, erythromycin B, erythromycin C, erythromycin D	Saccharopolyspora erythraea NRRL 2338
BGC0002084	0.68	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001605	0.67	Terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0002031	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0002406	0.65	Other	hydroxycinnamoyltyramine	Oryza sativa Japonica Group
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000278	0.64	Polyketide	urdamycin	Streptomyces fradiae
BGC0002347	0.63	Alkaloid	cyanogramide, cyanogramide B, cyanogramide C, cyanogramide D	Actinoalloteichus cyanogriseus
BGC0000016	0.63	Other	amphotericin B	Streptomyces nodosus
BGC0001163	0.62	Polyketide	1-heptadecene	Moorea producens 3L

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 54612:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ohmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: SACE_0721 + SACE_0723 + SACE_0724

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SACE_0721

PKS_AT (110..404): pk

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; 2-Methylbutyryl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 229.4
2-Methylbutyryl-CoA: 182.9
Methylmalonyl-CoA: 140.2
Ethylmalonyl-CoA: 126.8
Methoxymalonyl-CoA: 117.9
CHC-CoA: 92.1
trans-1,2-CPDA: 86.4
Malonyl-CoA: 73.7
Acetyl-CoA: 51.1
fatty_acid: 46.2
Isobutyryl-CoA: 41.8
Benzoyl-CoA: 31.9
3-Methylbutyryl-CoA: 26.4
inactive: 22.0

PKS_AT (1085..1386): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 218.9
Ethylmalonyl-CoA: 207.0
Methoxymalonyl-CoA: 181.8
2-Methylbutyryl-CoA: 138.0
trans-1,2-CPDA: 125.3
Propionyl-CoA: 118.8
Malonyl-CoA: 102.2
CHC-CoA: 82.9
Isobutyryl-CoA: 77.6
Benzoyl-CoA: 59.9
Acetyl-CoA: 51.0
fatty_acid: 44.9
3-Methylbutyryl-CoA: 35.0
inactive: 31.7

PKS_AT (2563..2861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.3
Ethylmalonyl-CoA: 207.3
Methoxymalonyl-CoA: 168.2
2-Methylbutyryl-CoA: 151.4
trans-1,2-CPDA: 116.0
Propionyl-CoA: 115.1
Malonyl-CoA: 100.9
CHC-CoA: 95.8
Isobutyryl-CoA: 69.9
Benzoyl-CoA: 63.1
Acetyl-CoA: 40.3
3-Methylbutyryl-CoA: 35.9
fatty_acid: 23.1
inactive: 21.3

SACE_0723

PKS_AT (561..860): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.8
Ethylmalonyl-CoA: 200.7
Methoxymalonyl-CoA: 170.0
2-Methylbutyryl-CoA: 135.5
trans-1,2-CPDA: 112.4
Malonyl-CoA: 100.4
Propionyl-CoA: 98.1
CHC-CoA: 89.1
Isobutyryl-CoA: 81.7
Benzoyl-CoA: 66.6
inactive: 45.7
Acetyl-CoA: 41.4
3-Methylbutyryl-CoA: 39.3
fatty_acid: 25.9

PKS_AT (2015..2311): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.9
Ethylmalonyl-CoA: 190.4
Methoxymalonyl-CoA: 170.2
2-Methylbutyryl-CoA: 140.0
trans-1,2-CPDA: 121.2
Propionyl-CoA: 100.9
Malonyl-CoA: 92.3
CHC-CoA: 81.0
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 61.9
Acetyl-CoA: 58.7
inactive: 35.5
fatty_acid: 35.2
3-Methylbutyryl-CoA: 26.7

SACE_0724

PKS_AT (555..852): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.1
Ethylmalonyl-CoA: 206.8
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 144.5
trans-1,2-CPDA: 129.9
Propionyl-CoA: 111.3
Malonyl-CoA: 105.3
CHC-CoA: 99.0
Isobutyryl-CoA: 98.0
Benzoyl-CoA: 84.1
Acetyl-CoA: 62.6
3-Methylbutyryl-CoA: 47.4
fatty_acid: 42.6
inactive: 31.6

PKS_AT (2018..2309): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.2
Ethylmalonyl-CoA: 202.8
Methoxymalonyl-CoA: 174.6
2-Methylbutyryl-CoA: 140.8
Malonyl-CoA: 120.1
trans-1,2-CPDA: 120.0
Propionyl-CoA: 106.2
CHC-CoA: 90.8
Isobutyryl-CoA: 67.3
Benzoyl-CoA: 53.1
Acetyl-CoA: 37.5
fatty_acid: 33.5
inactive: 28.5
3-Methylbutyryl-CoA: 21.1