BGC0000057 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000057 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	46,502	High	F9775A/F9775B/orsellinic acid	PKS:Iterative type I

BGC0000057 - Region 1 - T1PKS

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Location: 1 - 46,502 nt. (total: 46,502 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,503
Label		BGC0000057

Tailoring functions

Oxidoreductases: dehydrogenase

AN7914.2: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Ligases: synthase

AN7909.2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: permease

AN7916.2: phenylalanine-specific permease

smcogs: SMCOG1038: phenylalanine-specific permease

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000057.5	1.00	PKS	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000057.5	1.00	PKS	F9775A, F9775B, orsellinic acid	Aspergillus nidulans FGSC A4
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001284.4	0.76	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.76	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0002191.2	0.63	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 46502:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AN7909.2: mal

PKS_AT (883..1190): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 122.6
inactive: 77.8
Methoxymalonyl-CoA: 72.3
Methylmalonyl-CoA: 72.1
Ethylmalonyl-CoA: 40.1
Isobutyryl-CoA: 34.1
Propionyl-CoA: 33.5
2-Methylbutyryl-CoA: 26.8
Benzoyl-CoA: 20.3
Acetyl-CoA: 18.9
trans-1,2-CPDA: 17.3
CHC-CoA: 17.1
3-Methylbutyryl-CoA: 16.8
fatty_acid: 13.9

Link to PARAS substrate predictor