BGC0000057: F9775A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 122,623 - 149,174 nt. (total: 26,552 nt).
This entry is originally from NCBI GenBank AACD01000135.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000057
Short description F9775A biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AACD01000135.1
Compounds
  • F9775A
  • F9775B
  • orsellinic acid
Species Aspergillus nidulans FGSC A4 [taxonomy]
References
Chemical products information
F9775A
Copy SMILES
C21H16O8
Chemical database entries
PubCHEM
F9775B
Copy SMILES
C21H16O8
Chemical database entries
PubCHEM
orsellinic acid [synonyms: orsellic acid, o-orsellinic acid, orcinolcarboxylic acid, benzoic acid]
Copy SMILES
C8H8O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AN7907.2
  • EAA59561.1
 122623 - 123174 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AN7908.2
  • EAA59562.1
 126507 - 127484 (-) hypothetical protein
copy AA seq
copy Nt seq
  • AN7909.2
  • EAA59563.1
 128096 - 134597 (-) polyketide synthase
  • Scaffold biosynthesis
Knock-out
copy AA seq
copy Nt seq
  • AN7910.2
  • EAA59564.1
 135422 - 136114 (+) NTF2-like superfamily protein, putative
copy AA seq
copy Nt seq
  • AN7911.2
  • EAA59565.1
 136228 - 137290 (-) aminohydrolase, putative
  • Tailoring (Unknown)
Knock-out
copy AA seq
copy Nt seq
  • AN7912.2
  • EAA59566.1
 137660 - 138834 (+) tyrosinase, putative
  • Tailoring (Unknown)
Knock-out
copy AA seq
copy Nt seq
  • AN7913.2
  • EAA59567.1
 139355 - 140860 (-) conserved hypothetical protein
  • Unknown
Knock-out
copy AA seq
copy Nt seq
  • AN7914.2
  • EAA59568.1
 141414 - 142516 (+) alcohol dehydrogenase, putative
  • Unknown
Knock-out
copy AA seq
copy Nt seq
  • AN7915.2
  • EAA59569.1
 142746 - 146016 (-) glucosidase, putative
  • Unknown
Knock-out
copy AA seq
copy Nt seq
  • AN7916.2
  • EAA59570.1
 147256 - 149174 (-) hypothetical protein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? yes
Release type
  • Claisen condensation
Polyketide-synthases
Genes Properties Modules
AN7909.2 Synthase subclass: Iterative type I
Iterative PKS type: Non-reducing, C2-C7 first
Iteration counts: 3
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: AN7909.2
Core domains: ACP transacylase, Ketosynthase, Acyltransferase, Product Template domain, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thioesterase
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: J4R6BDENZAM7XVDGVEEHZB2Y, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.