Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000057.1:
Cluster 1Polyketide126552

BGC0000057, F9775 biosynthetic gene cluster from Aspergillus nidulans. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: F9775A
PubChem ID: 9843671
SMILES string: Copy to clipboard
Molecular formula: C21H16O8
Average molecular mass: 396.351 Da
Molecular activity: Inhibitor
Molecular target: inhibitor of cathepsin K

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
Iterative PKS subtype:
Non-reducing
Number of iterations:
3
C2-C7 first
Thioesterase type:
Other
Release / cyclization type:
Claisen condensation

Modular polyketide synthases:
orsA (EAA59563.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None
Module is iterated
Evidence for iteration: Unknown

Gene cluster description

F9775 (BGC0000057). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AACD01000135, positions 207766-225686. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Philipp Wiemann, Nancy Keller (University of Wisconsin-Madison)

Literature references

1. Sanchez JF et al. (2010) Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Mol Biosyst 6(3):587-93. doi: 10.1039/b904541d. Epub 2009 Dec 16.
2. Carter P. (1997) Evaluation of a policy of total mesorectal excision for rectal and rectosigmoid cancers. Br J Surg 84(12):1749-50.
3. Schroeckh V et al. (2009) Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A 106(34):14558-63. doi: