BGC0000059 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000059 (Streptomyces avermitilis MA-4680 = NBRC 14893)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	108,172	High	filipin	PKS

BGC0000059 - Region 1 - T1PKS

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Location: 1 - 108,172 nt. (total: 108,172 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 108,173
Label		BGC0000059

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

SAV_412: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

SAV_413: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

SAV_414: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: esterase

SAV_407: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: synthase

SAV_415: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SAV_416: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SAV_417: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

SAV_418: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

SAV_419: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000059.5	1.00	PKS	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002032.4	0.84	PKS	pentamycin	Streptomyces sp. S816
BGC0002789.2	0.76	PKS	pentamycin, filipin	Streptomyces lavendulae strain YAKB-15
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0000058.5	0.67	PKS	FD-891	Streptomyces graminofaciens
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000059.5	1.00	PKS	filipin	Streptomyces avermitilis MA-4680 = NBRC 14893
BGC0002032.4	0.84	PKS	pentamycin	Streptomyces sp. S816
BGC0002789.2	0.76	PKS	pentamycin, filipin	Streptomyces lavendulae strain YAKB-15
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0000058.5	0.67	PKS	FD-891	Streptomyces graminofaciens
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 108172:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ohmal - ccmal - ccmal - ccmal) + (ccmal - pk) + (ccmal) + (ohmal - ohmal - ohmal - ohmal) + (ohmal - pk)
Non-colinear ordering:: SAV_419 + SAV_418 + SAV_417 + SAV_416 + SAV_415

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

SAV_415: mal - pk

PKS_AT (563..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.4
inactive: 103.9
Methoxymalonyl-CoA: 71.0
Methylmalonyl-CoA: 64.7
Propionyl-CoA: 38.4
Ethylmalonyl-CoA: 35.4
CHC-CoA: 26.0
Benzoyl-CoA: 23.9
Acetyl-CoA: 22.9
Isobutyryl-CoA: 20.2
trans-1,2-CPDA: 17.7
2-Methylbutyryl-CoA: 15.2
fatty_acid: 10.4
3-Methylbutyryl-CoA: 0.0

PKS_AT (2068..2365): pk

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 79.2%; Ethylmalonyl-CoA: 75.0%; Methylmalonyl-CoA: 75.0%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 196.2
Methylmalonyl-CoA: 186.9
Methoxymalonyl-CoA: 174.1
2-Methylbutyryl-CoA: 135.1
trans-1,2-CPDA: 131.2
Propionyl-CoA: 114.2
CHC-CoA: 98.8
Isobutyryl-CoA: 96.6
Malonyl-CoA: 92.5
Benzoyl-CoA: 72.9
Acetyl-CoA: 53.7
fatty_acid: 51.5
3-Methylbutyryl-CoA: 36.3
inactive: 29.4

SAV_416: mal - mal - mal - mal

PKS_AT (559..839): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.9
inactive: 114.8
Methylmalonyl-CoA: 62.2
Methoxymalonyl-CoA: 61.7
Propionyl-CoA: 40.3
2-Methylbutyryl-CoA: 30.0
Ethylmalonyl-CoA: 29.0
Isobutyryl-CoA: 28.7
Benzoyl-CoA: 27.9
Acetyl-CoA: 21.6
CHC-CoA: 20.7
trans-1,2-CPDA: 20.1
fatty_acid: 11.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2072..2347): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 214.5
inactive: 112.0
Methoxymalonyl-CoA: 56.5
Methylmalonyl-CoA: 56.4
Propionyl-CoA: 33.6
Ethylmalonyl-CoA: 23.7
Isobutyryl-CoA: 23.1
Acetyl-CoA: 21.9
Benzoyl-CoA: 21.6
2-Methylbutyryl-CoA: 21.1
CHC-CoA: 18.6
fatty_acid: 14.7
trans-1,2-CPDA: 8.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (3576..3859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.1
inactive: 106.0
Methoxymalonyl-CoA: 60.0
Methylmalonyl-CoA: 52.6
Propionyl-CoA: 26.3
Isobutyryl-CoA: 18.4
Ethylmalonyl-CoA: 17.0
Benzoyl-CoA: 15.9
Acetyl-CoA: 12.8
2-Methylbutyryl-CoA: 10.6
trans-1,2-CPDA: 10.5
CHC-CoA: 4.5
3-Methylbutyryl-CoA: 4.1
fatty_acid: 0.0

PKS_AT (5103..5378): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.1
inactive: 111.0
Methoxymalonyl-CoA: 60.6
Methylmalonyl-CoA: 58.3
Propionyl-CoA: 31.9
Acetyl-CoA: 30.1
Ethylmalonyl-CoA: 26.6
Benzoyl-CoA: 24.5
Isobutyryl-CoA: 23.3
2-Methylbutyryl-CoA: 19.1
CHC-CoA: 16.0
fatty_acid: 10.8
trans-1,2-CPDA: 8.8
3-Methylbutyryl-CoA: 0.0

SAV_417: mal

PKS_AT (575..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.1
inactive: 118.8
Methoxymalonyl-CoA: 62.7
Methylmalonyl-CoA: 57.5
Propionyl-CoA: 38.9
Ethylmalonyl-CoA: 29.3
2-Methylbutyryl-CoA: 28.6
Isobutyryl-CoA: 23.1
Benzoyl-CoA: 21.7
Acetyl-CoA: 18.7
trans-1,2-CPDA: 17.3
CHC-CoA: 13.8
fatty_acid: 9.5
3-Methylbutyryl-CoA: 0.0

SAV_418: mal - pk

PKS_AT (585..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.2
inactive: 105.4
Methoxymalonyl-CoA: 62.6
Methylmalonyl-CoA: 54.6
Propionyl-CoA: 40.1
Acetyl-CoA: 27.6
Benzoyl-CoA: 25.4
2-Methylbutyryl-CoA: 23.6
Ethylmalonyl-CoA: 20.3
trans-1,2-CPDA: 16.9
Isobutyryl-CoA: 12.9
CHC-CoA: 12.2
fatty_acid: 11.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2310..2605): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 197.5
Methylmalonyl-CoA: 188.3
Methoxymalonyl-CoA: 158.6
2-Methylbutyryl-CoA: 137.6
trans-1,2-CPDA: 129.9
Propionyl-CoA: 102.8
CHC-CoA: 84.3
Malonyl-CoA: 80.5
Isobutyryl-CoA: 79.0
Benzoyl-CoA: 58.5
Acetyl-CoA: 45.8
3-Methylbutyryl-CoA: 25.6
fatty_acid: 16.4
inactive: 15.2

SAV_419: mal - mal - mal - mal - mal

PKS_AT (552..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.8
inactive: 121.1
Methoxymalonyl-CoA: 65.8
Methylmalonyl-CoA: 54.5
Isobutyryl-CoA: 32.5
Propionyl-CoA: 32.4
Acetyl-CoA: 20.2
Ethylmalonyl-CoA: 15.4
Benzoyl-CoA: 14.6
2-Methylbutyryl-CoA: 10.2
CHC-CoA: 9.9
trans-1,2-CPDA: 9.8
fatty_acid: 9.7
3-Methylbutyryl-CoA: 0.0

PKS_AT (1578..1858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 211.6
inactive: 114.8
Methoxymalonyl-CoA: 61.0
Methylmalonyl-CoA: 57.5
Propionyl-CoA: 32.6
Acetyl-CoA: 30.6
Ethylmalonyl-CoA: 28.7
Isobutyryl-CoA: 24.4
Benzoyl-CoA: 22.2
CHC-CoA: 20.6
2-Methylbutyryl-CoA: 19.9
trans-1,2-CPDA: 8.7
fatty_acid: 7.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (3081..3361): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.5
inactive: 105.4
Methoxymalonyl-CoA: 49.0
Methylmalonyl-CoA: 45.1
Propionyl-CoA: 26.9
Benzoyl-CoA: 21.0
2-Methylbutyryl-CoA: 17.2
Ethylmalonyl-CoA: 15.7
Isobutyryl-CoA: 15.3
CHC-CoA: 13.6
Acetyl-CoA: 12.3
trans-1,2-CPDA: 10.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4815..5095): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.2
inactive: 114.4
Methoxymalonyl-CoA: 57.1
Methylmalonyl-CoA: 51.9
Ethylmalonyl-CoA: 27.9
Propionyl-CoA: 26.0
Benzoyl-CoA: 22.6
Acetyl-CoA: 22.4
Isobutyryl-CoA: 21.4
2-Methylbutyryl-CoA: 18.9
CHC-CoA: 16.7
trans-1,2-CPDA: 13.8
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (6501..6771): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.6
inactive: 107.5
Methoxymalonyl-CoA: 57.0
Methylmalonyl-CoA: 53.9
Acetyl-CoA: 36.7
Propionyl-CoA: 30.5
Ethylmalonyl-CoA: 26.9
Isobutyryl-CoA: 18.6
2-Methylbutyryl-CoA: 17.8
Benzoyl-CoA: 17.4
CHC-CoA: 13.9
trans-1,2-CPDA: 12.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor