BGC0000062 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000062 ([Gibberella] fujikuroi var. moniliformis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	62,742	High	Fumonisin B1/Fumonisin B2/Fumonisin B3	PKS

BGC0000062 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 62,742 nt. (total: 62,742 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 62,743
Label		BGC0000062

Tailoring functions

Oxidoreductases: oxygenase

FUM15: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

FUM2: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

FUM6: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Lyases: dehydratase

FUM13: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: ligase synthase

FUM1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

FUM10: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FUM14: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

FUM16: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

FUM8: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000062.4	0.92	PKS	Fumonisin B1, Fumonisin B2, Fumonisin B3	Fusarium verticillioides
BGC0000063.3	0.79	PKS	hydroxyl-Fumonisin C1, Fumonisin C1, Fumonisin C2, Fumonisin C3, Fumonisin B1	Fusarium oxysporum
BGC0002502.3	0.78	PKS	fumonisin B3, fumonisin B2, fumonisin B1	Fusarium fujikuroi
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.63	PKS	FR901512	fungal sp. No.14919
BGC0001268.4	0.63	NRPS, PKS	fusarin C	Fusarium fujikuroi

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000062.4	0.99	PKS	Fumonisin B1, Fumonisin B2, Fumonisin B3	Fusarium verticillioides
BGC0000063.3	0.85	PKS	hydroxyl-Fumonisin C1, Fumonisin C1, Fumonisin C2, Fumonisin C3, Fumonisin B1	Fusarium oxysporum
BGC0002502.3	0.83	PKS	fumonisin B3, fumonisin B2, fumonisin B1	Fusarium fujikuroi
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002192.3	0.66	PKS	FR901512	fungal sp. No.14919
BGC0001244.3	0.66	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.65	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001268.4	0.65	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata

Similar known clusters from MIBiG 4.0

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 48163:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FUM1: pk

PKS_AT (608..914): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; 2-Methylbutyryl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 87.6
Methoxymalonyl-CoA: 75.9
Malonyl-CoA: 61.4
Isobutyryl-CoA: 53.5
Ethylmalonyl-CoA: 52.0
Propionyl-CoA: 43.5
trans-1,2-CPDA: 35.4
3-Methylbutyryl-CoA: 24.7
2-Methylbutyryl-CoA: 24.3
inactive: 21.1
Benzoyl-CoA: 20.7
fatty_acid: 20.6
CHC-CoA: 19.8
Acetyl-CoA: 10.4

FUM10: X

AMP-binding (30..453): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IIAHRGVPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

FUM16: X

AMP-binding (79..542): X

nrpys: (unknown)

SVM prediction details:

NOTE: uncertain match

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EMEV-C--FK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor