Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000062.1:
Cluster 1Polyketide175654

BGC0000062, fumonisin biosynthetic gene cluster from Fusarium verticillioides. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: fumonisin
PubChem ID: 3431
SMILES string: Copy to clipboard
Molecular formula: C34H59NO15
Average molecular mass: 721.838 Da

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide synthase subclass:
Type I

Gene cluster description

fumonisin (BGC0000062). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF155773. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

Literature references

1. Proctor RH et al. (1999) A polyketide synthase gene required for biosynthesis of fumonisin mycotoxins in Gibberella fujikuroi mating population A. Fungal Genet Biol 27(1):100-12. doi: 10.1006/fgbi.1999.1141.
2. Seo JA et al. (2001) Characterization of four clustered and coregulated genes associated with fumonisin biosynthesis in Fusarium verticillioides. Fungal Genet Biol 34(3):155-65. doi: 10.1006/fgbi.2001.1299.
3. Desjardins AE et al. (2002) FUM1--a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliformis in field tests. Mol Plant Microbe Interact 15(11):1157-64. doi:
4. Proctor RH et al. (2003) Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis. Fungal Genet Biol 38(2):237-49.
5. Butchko RA et al. (2003) FUM9 is required for C-5 hydroxylation of fumonisins and complements the meitotically defined Fum3 locus in Gibberella moniliformis. Appl Environ Microbiol 69(11):6935-7.
6. Proctor RH et al. (2006) Fumonisin production in the maize pathogen Fusarium verticillioides: genetic basis of naturally occurring chemical variation. J Agric Food Chem 54(6):2424-30. doi: 10.1021/jf0527706.
7. Brown DW et al. (2007) The Fusarium verticillioides FUM gene cluster encodes a Zn(II)2Cys6 protein that affects FUM gene expression and fumonisin production. Eukaryot Cell 6(7):1210-8. doi: 10.1128/EC.00400-06. Epub 2007 May 4.