BGC0000063 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000063 (Fusarium oxysporum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	53,327	hydroxyl-Fumonisin C1/Fumonisin C1/Fumonisin C2/Fumonisin C3/Fumonisin B1	PKS	100%

BGC0000063 - Region 1 - T1PKS

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Location: 1 - 53,327 nt. (total: 53,327 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 53,328
Label		BGC0000063

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000063	0.77	Polyketide	fumonisin	Fusarium oxysporum
BGC0000062	0.56	Polyketide	fumonisin B1	Fusarium verticillioides
BGC0002502	0.54	Polyketide	fumonisin B3, fumonisin B2, fumonisin B1	Fusarium fujikuroi
BGC0002525	0.37	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001893	0.34	Other	abscisic acid	Botrytis cinerea B05.10
BGC0000146	0.33	Polyketide	solanapyrone D	Alternaria solani
BGC0002191	0.32	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002245	0.32	Terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5
BGC0002162	0.31	Terpene	sesterfisherol, sesterfisheric acid, compound 6, compound 7a, compound 5, compound 8	Aspergillus fischeri NRRL 181
BGC0001528	0.31	Terpene	betaestacin	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000063	1.00	Polyketide	fumonisin	Fusarium oxysporum
BGC0000062	0.88	Polyketide	fumonisin B1	Fusarium verticillioides
BGC0002502	0.85	Polyketide	fumonisin B3, fumonisin B2, fumonisin B1	Fusarium fujikuroi
BGC0002525	0.69	Polyketide	fusarubin, 1233A, 1233B, NG-391, lucilactaene	Fusarium sp.
BGC0001286	0.68	Other	itaconic acid	Ustilago maydis
BGC0001893	0.67	Other	abscisic acid	Botrytis cinerea B05.10
BGC0000146	0.66	Polyketide	solanapyrone D	Alternaria solani
BGC0002191	0.65	Polyketide	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0002406	0.65	Other	hydroxycinnamoyltyramine	Oryza sativa Japonica Group
BGC0002245	0.65	Terpene	terpestacin, preterpestacin 3, preterpestacin 2, preterpestacin 1	Bipolaris maydis C5

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 35569:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

fum1

PKS_AT (608..914): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Methoxymalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 93.5
Methoxymalonyl-CoA: 82.2
Ethylmalonyl-CoA: 58.9
Malonyl-CoA: 58.0
Isobutyryl-CoA: 51.1
Propionyl-CoA: 43.9
trans-1,2-CPDA: 39.3
3-Methylbutyryl-CoA: 30.7
Benzoyl-CoA: 25.8
2-Methylbutyryl-CoA: 24.3
inactive: 24.1
fatty_acid: 22.5
CHC-CoA: 18.9
Acetyl-CoA: 10.0

fum10

AMP-binding (30..459): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IIAHRGVPAK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

fum16

AMP-binding (83..542): X

nrpys: (unknown)

SVM prediction details:

NOTE: uncertain match

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: EMEVGV--FK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)