BGC0000065: rustmicin biosynthetic gene cluster from Streptomyces galbus
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Location: 1 - 41,591 nt. (total: 41,591 nt).
This entry is originally from NCBI GenBank GU300145.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000065
Short description rustmicin biosynthetic gene cluster from Streptomyces galbus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "GalABC is proposed as a novel type of PKS: bacterial highly-reducing type iterative PKS incorporating methylmalonyl-CoA with highly programmed beta-keto group modifications, a discrete AT, and no distinctive releasing domain."
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: GU300145.1
Compounds
  • rustmicin
Species Streptomyces galbus [taxonomy]
References
Chemical products information
rustmicin
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C21H32O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADE22325.1
 316 - 882 (-) transcriptional regulator
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  • ADE22326.1
 1377 - 2183 (+) dehydrogenase
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  • ADE22327.1
 2493 - 3554 (+) oxidoreductase
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  • ADE22328.1
 3617 - 4534 (+) hydrolase
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  • ADE22329.1
 4877 - 5941 (-) DNA binding protein
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  • ADE22330.1
 6089 - 7318 (+) O-methyltransferase
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  • ADE22331.1
  • galG
 7494 - 8156 (+) GalG
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  • ADE22332.1
  • galH
 8134 - 9288 (-) GalH
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  • ADE22333.1
  • galI
 9291 - 10400 (-) GalI
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  • ADE22334.1
  • galJ
 10393 - 10695 (-) GalJ
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  • ADE22335.1
  • galK
 10692 - 11582 (-) GalK
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  • ADE22336.1
 11621 - 12706 (-) Rieske domain protein
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  • ADE22337.1
 12735 - 14207 (-) cytochrome P450-type monooxygenase
  • Activation / processing
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  • ADE22338.1
 14204 - 15139 (-) KS fold with no cysteine catalytic residue; a partner of GalB
  • Scaffold biosynthesis
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  • ADE22339.1
 15243 - 21389 (-) iterative type I PKS (highly reducing type)
  • Scaffold biosynthesis
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  • ADE22340.1
 21458 - 22963 (-) standing alone acyltransferase working with iterative type I PKS, GalB
  • Scaffold biosynthesis
Sequence-based prediction
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  • ADE22341.1
 23673 - 25190 (+) oxidoreductase
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  • ADE22342.1
 25426 - 26265 (-) transcriptional regulator
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  • ADE22343.1
 26351 - 27316 (+) dehydratase
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  • ADE22344.1
 27474 - 28811 (+) transport protein
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  • ADE22345.1
 28883 - 30217 (+) dehydratase
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  • ADE22346.1
 31383 - 32459 (-) transcriptional regulator
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  • ADE22347.1
 32684 - 33256 (-) transcriptional regulator
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  • ADE22348.1
 33666 - 34529 (+) lipoprotein
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  • ADE22349.1
 34559 - 35158 (+) peptidase
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  • ADE22350.1
 35163 - 35615 (+) unknown
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  • ADE22351.1
 36047 - 36994 (-) fatty acid desaturase
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  • ADE22352.1
 37173 - 38183 (-) oxidoreductase
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  • ADE22353.1
 38315 - 39454 (+) unknown
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  • ADE22354.1
 40619 - >41590 (-) unknown
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Polyketide-specific information
Subclass Macrolide
Starter unit Propionyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
ADE22339.1 Synthase subclass: Iterative type I
Iterative PKS type: Highly reducing, Unknown
Iteration counts: 6
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: KT6LT7RJM7ROU6KBJOTWGU5X, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fix extra newline in entry comment
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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