BGC0000065 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000065 (Streptomyces galbus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like	1	41,591	High	rustmicin	PKS:Iterative type I

BGC0000065 - Region 1 - PKS-like

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Location: 1 - 41,591 nt. (total: 41,591 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,592
Label		BGC0000065

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

ADE22326.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ADE22327.1: NADH:flavin oxidoreductase/NADH oxidase

smcogs: SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

ADE22337.1: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

ADE22341.1: dehydrogenase

smcogs: SMCOG1222: dehydrogenase

galI: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

galK: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

Transferases: acylase methyltransferase

ADE22330.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

ADE22340.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase phosphatase

ADE22328.1: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

galH: FkbH like protein

smcogs: SMCOG1256: FkbH like protein

Isomerases: racemase

ADE22345.1: mandelate racemase/muconate lactonizing enzyme

smcogs: SMCOG1268: mandelate racemase/muconate lactonizing enzyme

Ligases: synthase

ADE22338.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

ADE22339.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000065.5	0.99	PKS	rustmicin	Streptomyces galbus
BGC0000068.5	0.52	PKS	geldanamycin	Streptomyces hygroscopicus
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000798.3	0.46	saccharide	dhurrin	Sorghum bicolor
BGC0000675.5	0.46	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0001266.3	0.46	PKS	grayanic acid	Cladonia grayi
BGC0000886.4	0.46	other (other)	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0001264.3	0.45	PKS	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001813.4	0.44	NRPS	tyrobetaine	Streptomyces sp. NRRL WC-3703

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000065.5	1.00	PKS	rustmicin	Streptomyces galbus
BGC0000068.5	0.52	PKS	geldanamycin	Streptomyces hygroscopicus
BGC0002173.2	0.47	saccharide, terpene	fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol	Aspergillus fumigatus A1163
BGC0000798.3	0.46	saccharide	dhurrin	Sorghum bicolor
BGC0000675.5	0.46	terpene	(+)-T-muurolol	Streptomyces clavuligerus ATCC 27064
BGC0001266.3	0.46	PKS	grayanic acid	Cladonia grayi
BGC0000886.4	0.46	other (other)	allylmalonyl-CoA	Streptomyces tsukubensis
BGC0001264.3	0.45	PKS	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000090.4	0.44	PKS	macbecin, macbecin II	Actinosynnema pretiosum subsp. pretiosum
BGC0000867.3	0.44	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 35139:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mxmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ADE22340.1: mxmal

PKS_AT (6..279): mxmal

ATSignature: (unknown)

No matches above 50%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 17.0
Methylmalonyl-CoA: 14.0
Malonyl-CoA: 13.8
2-Methylbutyryl-CoA: 8.7
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor