BGC0000066: geldanamycin biosynthetic gene cluster from Streptomyces hygroscopicus
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Location: 1 - 69,644 nt. (total: 69,644 nt).
This entry is originally from NCBI GenBank AY179507.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000066
Short description geldanamycin biosynthetic gene cluster from Streptomyces hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AY179507.1
via
Compounds
  • geldanamycin
Species Streptomyces hygroscopicus [taxonomy]
References
Chemical products information
geldanamycin Evidence:
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C30H42N2O8
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAO06909.1
 1 - 684 (-) similar to predicted RhtB family transporters
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    • AAO06910.1
    		 771 - 1673 (-) putative secreted protein
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      • AAO06911.1
      		 1945 - 2736 (-) putative hydrolase
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        • AAO06912.1
        		 2890 - 3774 (+) putative transcriptional regulator
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          • AAO06913.1
          		 3824 - 4585 (-) putative transcriptional regulator
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            • AAO06914.1
            • gdmL
            		 4569 - 6065 (+) GdmL
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              • AAO06915.1
              • gdmX
              		 6107 - 6577 (-) GdmX
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                • AAO06916.1
                • gdmAI
                		 7208 - 27736 (+) GdmAI
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                  • AAO06917.1
                  • gdmAII
                  		 27794 - 38101 (+) GdmAII
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                    • AAO06918.1
                    • gdmAIII
                    		 38128 - 49818 (+) GdmAIII
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                      • AAO06919.1
                      • gdmF
                      		 49827 - 50600 (+) GdmF
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                        • AAO06920.1
                        • gdmM
                        		 50597 - 52234 (+) GdmM
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                          • AAO06921.1
                          • gdmN
                          		 53012 - 55060 (-) GdmN
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                            • AAO06922.1
                            • gdmH
                            		 55122 - 56234 (-) GdmH
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                              • AAO06923.1
                              • gdmI
                              		 56231 - 57343 (-) GdmI
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                                • AAO06924.1
                                • gdmJ
                                		 57340 - 57615 (-) GdmJ
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                                  • AAO06925.1
                                  • gdmK
                                  		 57612 - 58478 (-) GdmK
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                                    • AAO06926.1
                                    • gdmG
                                    		 58722 - 59378 (+) GdmG
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                                      • AAO06927.1
                                      • gdmRII
                                      		 59503 - 62283 (-) GdmRII
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                                        • AAO06928.1
                                        • gdmO
                                        		 62558 - 63622 (-) GdmO
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                                          • AAO06929.1
                                          • gdmP
                                          		 63940 - 65133 (-) GdmP
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                                            • AAO06930.1
                                            • gdmRI
                                            		 65290 - 68178 (-) GdmRI
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                                              • AAO06931.1
                                              		 68931 - 69644 (+) putative hydrolase
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (NPAtlas curation)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
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