BGC0000067 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000067 (Streptomyces hygroscopicus subsp. duamyceticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	75,920	candicidin	NRPS:Type I+PKS	23%

BGC0000067 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 75,920 nt. (total: 75,920 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 75,921
Label		BGC0000067

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000067	1.68	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000066	0.88	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041	0.78	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000074	0.64	Polyketide	herbimycin A	Streptomyces hygroscopicus
BGC0001163	0.59	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001275	0.57	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000143	0.54	Polyketide	salinomycin	Streptomyces albus
BGC0000090	0.53	Polyketide	macbecin, macbecin II	Actinosynnema pretiosum subsp. pretiosum
BGC0000094	0.53	Polyketide, Saccharide	methymycin	Streptomyces venezuelae
BGC0000018	0.50	Polyketide	angolamycin	Streptomyces eurythermus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000067	1.00	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000066	0.79	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000041	0.71	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000074	0.66	Polyketide	herbimycin A	Streptomyces hygroscopicus
BGC0001163	0.63	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000090	0.63	Polyketide	macbecin, macbecin II	Actinosynnema pretiosum subsp. pretiosum
BGC0001273	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000068	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001051	0.58	NRP, Polyketide	thuggacin A	Sorangium cellulosum

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 75920:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal - redmxmal - Me-ohmal) + (Me-ccmal - ohmxmal) + (redmal - Me-ccmal)
Non-colinear ordering:: ABB86408.1 + ABB86409.1 + ABB86410.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ABB86408.1

CAL_domain (34..442): pk

minowa: AHBA

Prediction, score:

AHBA: 538.5
shikimic_acid: 267.8
Acetyl-CoA: 12.5
fatty_acid: 0.0
NH2: 0.0

PKS_AT (1657..1954): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 204.6
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 124.0
Propionyl-CoA: 109.7
Malonyl-CoA: 102.6
trans-1,2-CPDA: 96.8
CHC-CoA: 73.8
Isobutyryl-CoA: 69.7
Benzoyl-CoA: 58.4
Acetyl-CoA: 36.8
3-Methylbutyryl-CoA: 36.6
fatty_acid: 25.1
inactive: 22.9

PKS_AT (3727..4027): mxmal

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 196.5
Methylmalonyl-CoA: 186.9
Ethylmalonyl-CoA: 180.8
2-Methylbutyryl-CoA: 134.0
trans-1,2-CPDA: 111.3
Propionyl-CoA: 96.3
Malonyl-CoA: 91.4
CHC-CoA: 87.9
Isobutyryl-CoA: 61.8
Benzoyl-CoA: 52.2
Acetyl-CoA: 42.1
3-Methylbutyryl-CoA: 37.9
inactive: 27.9
fatty_acid: 17.2

PKS_AT (5794..6093): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.8
Ethylmalonyl-CoA: 187.4
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 125.5
Propionyl-CoA: 106.0
Malonyl-CoA: 100.8
trans-1,2-CPDA: 94.6
CHC-CoA: 79.2
Isobutyryl-CoA: 67.5
Benzoyl-CoA: 61.2
Acetyl-CoA: 37.0
3-Methylbutyryl-CoA: 36.4
inactive: 24.0
fatty_acid: 23.4

ABB86409.1

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.5
Ethylmalonyl-CoA: 186.6
Methoxymalonyl-CoA: 169.2
2-Methylbutyryl-CoA: 123.1
Propionyl-CoA: 108.6
Malonyl-CoA: 100.1
trans-1,2-CPDA: 96.1
CHC-CoA: 72.7
Isobutyryl-CoA: 69.0
Benzoyl-CoA: 58.0
3-Methylbutyryl-CoA: 36.9
Acetyl-CoA: 34.3
fatty_acid: 25.3
inactive: 23.5

PKS_AT (2350..2650): mxmal

ATSignature: Methoxymalonyl-CoA

Top 3 matches:: Methoxymalonyl-CoA: 100.0%; Ethylmalonyl-CoA: 91.7%; Methylmalonyl-CoA: 91.7%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 198.1
Methylmalonyl-CoA: 189.5
Ethylmalonyl-CoA: 184.4
2-Methylbutyryl-CoA: 134.6
trans-1,2-CPDA: 110.3
Propionyl-CoA: 96.8
Malonyl-CoA: 94.7
CHC-CoA: 90.0
Isobutyryl-CoA: 63.6
Benzoyl-CoA: 54.2
Acetyl-CoA: 44.2
3-Methylbutyryl-CoA: 37.9
inactive: 27.4
fatty_acid: 17.3

ABB86410.1

PKS_AT (583..885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 231.5
inactive: 122.6
Methoxymalonyl-CoA: 70.3
Methylmalonyl-CoA: 62.7
Propionyl-CoA: 40.8
Isobutyryl-CoA: 32.2
Benzoyl-CoA: 29.7
Ethylmalonyl-CoA: 21.5
Acetyl-CoA: 18.5
trans-1,2-CPDA: 14.6
CHC-CoA: 13.1
fatty_acid: 10.8
2-Methylbutyryl-CoA: 10.5
3-Methylbutyryl-CoA: 0.0

PKS_AT (2663..2962): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.5
Ethylmalonyl-CoA: 189.0
Methoxymalonyl-CoA: 170.4
2-Methylbutyryl-CoA: 120.6
Propionyl-CoA: 106.5
Malonyl-CoA: 100.8
trans-1,2-CPDA: 95.7
CHC-CoA: 74.9
Isobutyryl-CoA: 67.2
Benzoyl-CoA: 62.8
Acetyl-CoA: 43.3
3-Methylbutyryl-CoA: 33.7
fatty_acid: 24.0
inactive: 18.7