BGC0000068 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000068 (Streptomyces hygroscopicus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	28,356	geldanamycin	PKS	100%

BGC0000068 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 28,356 nt. (total: 28,356 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,357
Label		BGC0000068

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000068	0.97	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000066	0.33	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001273	0.29	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002229	0.28	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000996	0.27	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002615	0.27	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000170	0.27	Polyketide	yanuthone D	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000068	0.99	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000066	0.66	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0002099	0.66	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001273	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002229	0.61	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000996	0.61	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0002615	0.61	Terpene	4-oxomacrophorin A, macrophorin A, 5'-epimacrophorin B	Penicillium terrestre
BGC0000170	0.60	Polyketide	yanuthone D	Aspergillus niger ATCC 1015

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 28356:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

gdmPKS

PKS_AT (1836..2133): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.0
Ethylmalonyl-CoA: 187.7
Methoxymalonyl-CoA: 171.6
2-Methylbutyryl-CoA: 124.1
Propionyl-CoA: 112.7
Malonyl-CoA: 102.1
trans-1,2-CPDA: 97.9
CHC-CoA: 82.8
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 56.8
Acetyl-CoA: 41.6
3-Methylbutyryl-CoA: 41.2
inactive: 26.8
fatty_acid: 26.2