BGC0000069 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000069 (Archangium violaceum Cb vi76)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	63,402	High	gephyronic acid	PKS

BGC0000069 - Region 1 - T1PKS

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Location: 1 - 63,402 nt. (total: 63,402 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 63,403
Label		BGC0000069

Tailoring functions

Oxidoreductases: oxygenase

gphK: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

gphL: monooxygenase FAD-binding

smcogs: SMCOG1246: monooxygenase FAD-binding

Transferases: methyltransferase

gphA: methyltransferase

smcogs: SMCOG1089: methyltransferase

Ligases: synthase

gphF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gphG: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

gphH: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

gphI: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

gphJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000069.5	0.99	PKS	gephyronic acid	Archangium violaceum Cb vi76
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.74	PKS	FR901512	fungal sp. No.14919
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001268.4	0.67	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000069.5	0.99	PKS	gephyronic acid	Archangium violaceum Cb vi76
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.74	PKS	FR901512	fungal sp. No.14919
BGC0001244.3	0.67	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001268.4	0.67	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 63402:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (Me-ohmal) + (Me-mal) + (Me-ccmal) + (ccmal)
Non-colinear ordering:: gphF + gphG + gphH + gphI + gphJ

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

gphF: mal

PKS_AT (1341..1623): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 173.0
inactive: 102.8
Methoxymalonyl-CoA: 41.3
Methylmalonyl-CoA: 40.2
Propionyl-CoA: 34.6
2-Methylbutyryl-CoA: 18.8
Isobutyryl-CoA: 18.0
CHC-CoA: 17.6
fatty_acid: 17.0
Benzoyl-CoA: 16.1
Acetyl-CoA: 10.3
Ethylmalonyl-CoA: 9.8
trans-1,2-CPDA: 9.2
3-Methylbutyryl-CoA: 0.0

gphG: mal

PKS_AT (451..730): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 133.5
inactive: 92.7
Methoxymalonyl-CoA: 62.0
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 43.8
Isobutyryl-CoA: 30.4
Benzoyl-CoA: 27.3
trans-1,2-CPDA: 27.0
2-Methylbutyryl-CoA: 23.6
CHC-CoA: 21.7
Ethylmalonyl-CoA: 20.0
Acetyl-CoA: 16.6
fatty_acid: 9.2
3-Methylbutyryl-CoA: 0.0

gphH: mal

PKS_AT (561..851): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 109.9
Methylmalonyl-CoA: 56.1
inactive: 49.5
Methoxymalonyl-CoA: 48.5
Ethylmalonyl-CoA: 30.0
Propionyl-CoA: 22.6
Benzoyl-CoA: 19.5
2-Methylbutyryl-CoA: 16.5
Acetyl-CoA: 14.2
CHC-CoA: 13.2
trans-1,2-CPDA: 11.7
fatty_acid: 9.6
Isobutyryl-CoA: 3.2
3-Methylbutyryl-CoA: 0.0

gphI: mal

PKS_AT (528..804): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 104.4
Methylmalonyl-CoA: 55.5
inactive: 47.6
Methoxymalonyl-CoA: 44.6
Propionyl-CoA: 28.1
2-Methylbutyryl-CoA: 27.7
CHC-CoA: 25.5
Acetyl-CoA: 20.3
Ethylmalonyl-CoA: 18.9
trans-1,2-CPDA: 18.1
3-Methylbutyryl-CoA: 12.6
Benzoyl-CoA: 12.4
Isobutyryl-CoA: 10.3
fatty_acid: 8.4

gphJ: mal

PKS_AT (570..859): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; inactive: 70.8%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 141.6
inactive: 101.9
Methoxymalonyl-CoA: 69.2
Methylmalonyl-CoA: 57.9
Propionyl-CoA: 33.9
Isobutyryl-CoA: 33.4
Benzoyl-CoA: 23.1
Acetyl-CoA: 23.0
Ethylmalonyl-CoA: 13.6
trans-1,2-CPDA: 13.3
2-Methylbutyryl-CoA: 12.6
3-Methylbutyryl-CoA: 12.3
CHC-CoA: 12.2
fatty_acid: 11.8

Link to PARAS substrate predictor