BGC0000070 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000070 (Penicillium aethiopicum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	55,000	griseofulvin/epidechlorogriseofulvin	PKS:Iterative type I	100%

BGC0000070 - Region 1 - T1PKS

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Location: 1 - 55,000 nt. (total: 55,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 55,001
Label		BGC0000070

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000070	1.00	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0001284	0.43	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002608	0.39	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002257	0.36	Polyketide	rufoschweinitzin	Xylaria schweinitzii
BGC0000156	0.35	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0002175	0.35	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0001583	0.35	Polyketide	emodin	Escovopsis weberi
BGC0001257	0.34	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107	0.34	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001304	0.34	Polyketide	aflavarin	Aspergillus flavus NRRL3357

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000070	1.00	Polyketide	griseofulvin, epidechlorogriseofulvin, norlichexanthone, dehydrogriseofulvin, 4-desmethylgriseofulvin, griseoxanthone B	Penicillium aethiopicum
BGC0001284	0.74	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002608	0.71	NRP, Polyketide	ochratoxin A	Aspergillus steynii
BGC0002257	0.69	Polyketide	rufoschweinitzin	Xylaria schweinitzii
BGC0000156	0.68	Polyketide	TAN-1612, 1-(2,3,5,10-tetrahydroxy-7-methoxy-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)pentane-2,4-dione, desmethyl TAN-1612	Aspergillus niger
BGC0002175	0.68	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0001583	0.68	Polyketide	emodin	Escovopsis weberi
BGC0001257	0.68	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107	0.68	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001304	0.67	Polyketide	aflavarin	Aspergillus flavus NRRL3357

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 1524 - 47196:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ADI24953.1

PKS_AT (923..1219): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Methoxymalonyl-CoA

Prediction, score:

Methoxymalonyl-CoA: 50.4
Malonyl-CoA: 50.3
Methylmalonyl-CoA: 43.0
inactive: 22.2
Ethylmalonyl-CoA: 19.7
Benzoyl-CoA: 15.8
fatty_acid: 15.6
Propionyl-CoA: 12.8
CHC-CoA: 10.7
2-Methylbutyryl-CoA: 10.4
Acetyl-CoA: 8.7
Isobutyryl-CoA: 8.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0