BGC0000072 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000072 (Pyxidicoccus fallax)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	34,905	High	gulmirecin A	PKS:Type I

BGC0000072 - Region 1 - T1PKS

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Location: 1 - 34,905 nt. (total: 34,905 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,906
Label		BGC0000072

Tailoring functions

Oxidoreductases: oxygenase

gulG: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

gulB: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

gulF: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Ligases: synthase

gulA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gulC: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

gulD: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

gulE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000072.5	1.00	PKS	gulmirecin A	Pyxidicoccus fallax
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000072.5	1.00	PKS	gulmirecin A	Pyxidicoccus fallax
BGC0001275.3	0.77	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.77	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001284.4	0.67	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.66	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 34905:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ohmal) + (Me-ccmal) + (Me-redmal)
Non-colinear ordering:: gulE + gulD + gulB + gulC + gulF

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

gulB: mal

PKS_AT (566..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 105.0
Methylmalonyl-CoA: 104.2
Methoxymalonyl-CoA: 101.6
Isobutyryl-CoA: 76.1
Propionyl-CoA: 58.5
Ethylmalonyl-CoA: 58.4
fatty_acid: 44.6
2-Methylbutyryl-CoA: 38.7
3-Methylbutyryl-CoA: 36.7
inactive: 36.3
Acetyl-CoA: 33.9
Benzoyl-CoA: 32.2
trans-1,2-CPDA: 29.3
CHC-CoA: 23.8

gulC: mmal

PKS_AT (569..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.8
Ethylmalonyl-CoA: 135.4
Methoxymalonyl-CoA: 122.7
Malonyl-CoA: 122.1
2-Methylbutyryl-CoA: 81.2
Isobutyryl-CoA: 73.7
trans-1,2-CPDA: 72.6
Propionyl-CoA: 71.7
CHC-CoA: 53.7
Acetyl-CoA: 50.3
Benzoyl-CoA: 46.4
inactive: 43.3
3-Methylbutyryl-CoA: 33.1
fatty_acid: 24.3

gulD: mal

PKS_AT (559..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 126.8
Methylmalonyl-CoA: 118.1
Isobutyryl-CoA: 108.3
Methoxymalonyl-CoA: 94.3
Ethylmalonyl-CoA: 77.2
inactive: 47.9
Benzoyl-CoA: 47.1
fatty_acid: 34.4
Propionyl-CoA: 30.7
trans-1,2-CPDA: 29.2
Acetyl-CoA: 27.4
CHC-CoA: 26.3
2-Methylbutyryl-CoA: 18.9
3-Methylbutyryl-CoA: 9.5

gulE: pk

PKS_AT (586..882): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 107.4
Malonyl-CoA: 104.6
Methoxymalonyl-CoA: 86.3
Propionyl-CoA: 74.0
Ethylmalonyl-CoA: 73.7
2-Methylbutyryl-CoA: 67.3
Isobutyryl-CoA: 65.8
inactive: 56.1
Benzoyl-CoA: 40.1
CHC-CoA: 38.6
trans-1,2-CPDA: 34.6
fatty_acid: 18.7
3-Methylbutyryl-CoA: 15.5
Acetyl-CoA: 14.2

gulF: mmal

PKS_AT (574..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 171.0
Ethylmalonyl-CoA: 134.4
Methoxymalonyl-CoA: 120.8
Malonyl-CoA: 99.9
Isobutyryl-CoA: 97.8
trans-1,2-CPDA: 88.0
Benzoyl-CoA: 78.2
Propionyl-CoA: 72.8
Acetyl-CoA: 56.6
CHC-CoA: 48.4
2-Methylbutyryl-CoA: 45.5
3-Methylbutyryl-CoA: 39.6
fatty_acid: 28.9
inactive: 26.9

gulA: mmal - mmal

PKS_AT (622..913): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 66.7%; Malonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 127.2
Ethylmalonyl-CoA: 105.6
Methoxymalonyl-CoA: 99.4
Isobutyryl-CoA: 95.0
Malonyl-CoA: 86.7
Benzoyl-CoA: 71.1
Acetyl-CoA: 63.5
Propionyl-CoA: 61.8
trans-1,2-CPDA: 61.6
2-Methylbutyryl-CoA: 55.1
CHC-CoA: 54.3
fatty_acid: 44.5
inactive: 27.2
3-Methylbutyryl-CoA: 26.6

PKS_AT (1051..1340): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 138.1
Methoxymalonyl-CoA: 134.1
Malonyl-CoA: 98.0
Propionyl-CoA: 91.9
2-Methylbutyryl-CoA: 87.7
Isobutyryl-CoA: 85.6
trans-1,2-CPDA: 80.2
Acetyl-CoA: 79.6
Benzoyl-CoA: 77.2
CHC-CoA: 51.2
fatty_acid: 45.9
3-Methylbutyryl-CoA: 45.4
inactive: 31.0

Link to PARAS substrate predictor