BGC0000072: gulmirecin A biosynthetic gene cluster from Pyxidicoccus fallax
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Location: 1 - 34,905 nt. (total: 34,905 nt).
This entry is originally from NCBI GenBank KM361622.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000072
Short description gulmirecin A biosynthetic gene cluster from Pyxidicoccus fallax
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: KM361622.1
Compounds
  • gulmirecin A
Species Pyxidicoccus fallax [taxonomy]
References
Chemical products information
gulmirecin A
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C27H42O11
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIT55258.1
  • gulG
 63 - 1247 (-) cytochrome P450
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AIT55259.1
  • gulB
 2050 - 6762 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AIT55260.1
  • gulC
 6790 - 12360 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AIT55261.1
  • gulD
 12404 - 17089 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AIT55262.1
  • gulE
 17104 - 20418 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AIT55263.1
  • gulF
 20420 - 27670 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AIT55264.1
  • gulA
 27712 - 34869 (+) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Macrolide
Starter unit Acetyl-CoA
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
gulD
+
gulB
+
gulE
+
gulA
+
gulC
+
gulF 		Synthase subclass: Modular type I
Module 0
Specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulA
Core domains: Thiolation (ACP/PCP), Ketosynthase, Acyltransferase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 1
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulA
Core domains: Thiolation (ACP/PCP), Ketosynthase, Acyltransferase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulC
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulE
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 6
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: gulF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: L-OH
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: YETYK72PRB3MT456E3R3XHBM, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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