BGC0000073 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000073 (Streptomyces halstedii)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	107,687	Medium	meridamycin	NRPS:Type I+PKS

BGC0000073 - Region 1 - T1PKS

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Location: 1 - 107,687 nt. (total: 107,687 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 107,688
Label		BGC0000073

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

hlsG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

hlsH: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

hlsI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Ligases: synthase

hlsA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hlsB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hlsC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hlsD: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hlsE: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

hlsF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000073.5	1.00	PKS	halstoctacosanolide A	Streptomyces halstedii
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.66	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000073.5	1.00	PKS	halstoctacosanolide A	Streptomyces halstedii
BGC0001273.3	0.76	PKS	asperlactone	Aspergillus ochraceus
BGC0001275.3	0.76	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.76	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.75	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0000041.3	0.68	PKS	oronofacic acid	Pseudomonas syringae
BGC0000067.5	0.66	PKS	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 107687:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ohmal - ohmal) + (ohmal - Me-ccmal - Me-redmal - ohmal) + (Me-ohmal - ccmal - ccmal) + (Me-redmal - ohmal - ohmal) + (Me-redmal - ohmal) + (Me-ccmal - Me-ccmal - ohmal) + (Me-ccmal)
Non-colinear ordering:: hlsA + hlsB + hlsC + hlsD + hlsE + hlsF + hlsG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

hlsA: mmal - mmal - mal

PKS_AT (538..832): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.6
Ethylmalonyl-CoA: 202.2
Methoxymalonyl-CoA: 166.4
2-Methylbutyryl-CoA: 124.5
trans-1,2-CPDA: 114.4
Malonyl-CoA: 110.4
Propionyl-CoA: 105.5
CHC-CoA: 90.6
Isobutyryl-CoA: 67.5
Acetyl-CoA: 53.8
Benzoyl-CoA: 49.7
inactive: 44.7
3-Methylbutyryl-CoA: 29.5
fatty_acid: 26.8

PKS_AT (1554..1848): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.1
Ethylmalonyl-CoA: 203.0
Methoxymalonyl-CoA: 168.9
trans-1,2-CPDA: 120.4
2-Methylbutyryl-CoA: 118.5
Malonyl-CoA: 116.0
Propionyl-CoA: 102.0
CHC-CoA: 86.0
Isobutyryl-CoA: 69.9
Benzoyl-CoA: 52.8
Acetyl-CoA: 50.9
inactive: 44.2
3-Methylbutyryl-CoA: 32.8
fatty_acid: 26.5

PKS_AT (3114..3407): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 212.5
inactive: 101.6
Methoxymalonyl-CoA: 66.0
Methylmalonyl-CoA: 59.6
Ethylmalonyl-CoA: 31.4
Propionyl-CoA: 27.1
Benzoyl-CoA: 25.6
Isobutyryl-CoA: 25.5
Acetyl-CoA: 25.3
2-Methylbutyryl-CoA: 18.9
CHC-CoA: 15.5
trans-1,2-CPDA: 11.2
fatty_acid: 10.7
3-Methylbutyryl-CoA: 0.0

hlsB: mal - mmal - mmal - mal

PKS_AT (569..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.5
inactive: 96.9
Methoxymalonyl-CoA: 61.4
Methylmalonyl-CoA: 53.9
Ethylmalonyl-CoA: 30.6
Acetyl-CoA: 25.5
Propionyl-CoA: 25.4
Benzoyl-CoA: 24.8
Isobutyryl-CoA: 24.3
2-Methylbutyryl-CoA: 19.2
CHC-CoA: 18.5
trans-1,2-CPDA: 10.8
fatty_acid: 9.9
3-Methylbutyryl-CoA: 0.0

PKS_AT (2116..2410): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 201.4
Ethylmalonyl-CoA: 191.8
Methoxymalonyl-CoA: 163.3
2-Methylbutyryl-CoA: 118.8
trans-1,2-CPDA: 110.3
Malonyl-CoA: 106.3
Propionyl-CoA: 100.8
CHC-CoA: 90.7
Isobutyryl-CoA: 63.9
Benzoyl-CoA: 49.0
Acetyl-CoA: 48.4
inactive: 44.1
3-Methylbutyryl-CoA: 28.2
fatty_acid: 24.8

PKS_AT (3889..4183): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.7
Ethylmalonyl-CoA: 201.0
Methoxymalonyl-CoA: 165.9
2-Methylbutyryl-CoA: 123.6
trans-1,2-CPDA: 119.1
Malonyl-CoA: 115.2
Propionyl-CoA: 105.2
CHC-CoA: 94.5
Isobutyryl-CoA: 73.7
Acetyl-CoA: 54.1
Benzoyl-CoA: 52.7
inactive: 48.0
3-Methylbutyryl-CoA: 35.2
fatty_acid: 28.4

PKS_AT (6023..6320): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.2
inactive: 95.5
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 55.5
Ethylmalonyl-CoA: 29.1
Isobutyryl-CoA: 27.9
Acetyl-CoA: 26.9
Benzoyl-CoA: 26.4
Propionyl-CoA: 25.4
CHC-CoA: 17.5
2-Methylbutyryl-CoA: 16.8
fatty_acid: 11.7
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0

hlsC: mmal - mal - mal

PKS_AT (567..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.4
Ethylmalonyl-CoA: 201.0
Methoxymalonyl-CoA: 167.1
2-Methylbutyryl-CoA: 123.5
trans-1,2-CPDA: 119.2
Malonyl-CoA: 111.9
Propionyl-CoA: 105.3
CHC-CoA: 91.5
Isobutyryl-CoA: 71.0
Acetyl-CoA: 54.2
Benzoyl-CoA: 52.8
inactive: 44.9
3-Methylbutyryl-CoA: 31.8
fatty_acid: 28.1

PKS_AT (2126..2419): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 94.8
Methoxymalonyl-CoA: 59.9
Methylmalonyl-CoA: 53.9
Ethylmalonyl-CoA: 29.1
Isobutyryl-CoA: 27.2
Acetyl-CoA: 26.5
Benzoyl-CoA: 26.2
Propionyl-CoA: 24.1
2-Methylbutyryl-CoA: 15.8
fatty_acid: 12.3
CHC-CoA: 12.3
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3907..4203): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.6
inactive: 98.2
Methoxymalonyl-CoA: 61.7
Methylmalonyl-CoA: 55.1
Ethylmalonyl-CoA: 28.9
Propionyl-CoA: 27.7
Isobutyryl-CoA: 26.6
Acetyl-CoA: 24.6
Benzoyl-CoA: 22.2
2-Methylbutyryl-CoA: 19.7
CHC-CoA: 12.8
trans-1,2-CPDA: 9.5
fatty_acid: 9.4
3-Methylbutyryl-CoA: 0.0

hlsD: mmal - mal - mal

PKS_AT (568..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.8
Ethylmalonyl-CoA: 202.1
Methoxymalonyl-CoA: 168.4
2-Methylbutyryl-CoA: 123.7
trans-1,2-CPDA: 116.2
Malonyl-CoA: 112.3
Propionyl-CoA: 104.9
CHC-CoA: 94.3
Isobutyryl-CoA: 70.8
Acetyl-CoA: 54.0
Benzoyl-CoA: 52.8
inactive: 44.9
3-Methylbutyryl-CoA: 32.3
fatty_acid: 28.6

PKS_AT (2677..2973): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 98.4
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 56.1
Ethylmalonyl-CoA: 30.5
Benzoyl-CoA: 24.9
Propionyl-CoA: 24.4
Isobutyryl-CoA: 24.4
Acetyl-CoA: 24.4
2-Methylbutyryl-CoA: 16.3
CHC-CoA: 13.7
trans-1,2-CPDA: 11.6
fatty_acid: 10.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (4226..4517): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.9
inactive: 104.2
Methoxymalonyl-CoA: 61.3
Methylmalonyl-CoA: 52.1
Acetyl-CoA: 29.3
Propionyl-CoA: 26.6
Ethylmalonyl-CoA: 26.3
Benzoyl-CoA: 18.8
2-Methylbutyryl-CoA: 18.2
Isobutyryl-CoA: 15.8
CHC-CoA: 12.5
trans-1,2-CPDA: 10.0
fatty_acid: 6.9
3-Methylbutyryl-CoA: 0.0

hlsE: mmal - mal

PKS_AT (565..859): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.6
Ethylmalonyl-CoA: 203.0
Methoxymalonyl-CoA: 167.8
2-Methylbutyryl-CoA: 120.5
Malonyl-CoA: 117.8
trans-1,2-CPDA: 113.4
Propionyl-CoA: 104.4
CHC-CoA: 83.6
Isobutyryl-CoA: 68.4
Acetyl-CoA: 53.6
Benzoyl-CoA: 50.5
inactive: 48.1
fatty_acid: 33.9
3-Methylbutyryl-CoA: 28.1

PKS_AT (2666..2969): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.3
inactive: 87.2
Methoxymalonyl-CoA: 60.2
Methylmalonyl-CoA: 52.7
Acetyl-CoA: 29.4
Propionyl-CoA: 23.3
Ethylmalonyl-CoA: 21.5
Benzoyl-CoA: 18.7
Isobutyryl-CoA: 16.0
CHC-CoA: 12.1
trans-1,2-CPDA: 9.5
fatty_acid: 9.5
2-Methylbutyryl-CoA: 8.9
3-Methylbutyryl-CoA: 0.0

hlsF: mmal - mmal - mal

PKS_AT (572..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.4
Ethylmalonyl-CoA: 201.6
Methoxymalonyl-CoA: 169.3
2-Methylbutyryl-CoA: 121.5
Malonyl-CoA: 115.7
trans-1,2-CPDA: 110.4
Propionyl-CoA: 104.0
CHC-CoA: 84.4
Isobutyryl-CoA: 69.2
Acetyl-CoA: 54.1
Benzoyl-CoA: 51.6
inactive: 48.1
fatty_acid: 34.2
3-Methylbutyryl-CoA: 29.1

PKS_AT (2359..2653): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.1
Ethylmalonyl-CoA: 205.1
Methoxymalonyl-CoA: 170.5
2-Methylbutyryl-CoA: 125.8
Malonyl-CoA: 117.8
trans-1,2-CPDA: 113.1
Propionyl-CoA: 107.3
CHC-CoA: 87.2
Isobutyryl-CoA: 71.0
Acetyl-CoA: 56.5
Benzoyl-CoA: 54.3
inactive: 48.8
fatty_acid: 37.2
3-Methylbutyryl-CoA: 28.8

PKS_AT (4151..4451): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 206.5
inactive: 89.2
Methoxymalonyl-CoA: 73.7
Methylmalonyl-CoA: 66.4
Ethylmalonyl-CoA: 34.8
Isobutyryl-CoA: 32.3
Acetyl-CoA: 30.3
Propionyl-CoA: 27.4
Benzoyl-CoA: 25.9
CHC-CoA: 23.9
fatty_acid: 21.8
trans-1,2-CPDA: 18.9
2-Methylbutyryl-CoA: 17.2
3-Methylbutyryl-CoA: 0.0

hlsG: mmal

PKS_AT (593..887): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.8
Ethylmalonyl-CoA: 204.7
Methoxymalonyl-CoA: 172.3
2-Methylbutyryl-CoA: 122.0
Malonyl-CoA: 114.2
trans-1,2-CPDA: 114.0
Propionyl-CoA: 102.2
CHC-CoA: 95.7
Isobutyryl-CoA: 72.4
Benzoyl-CoA: 54.7
Acetyl-CoA: 48.1
inactive: 43.9
3-Methylbutyryl-CoA: 35.0
fatty_acid: 26.1

Link to PARAS substrate predictor