BGC0000075: hygrocin A biosynthetic gene cluster from Streptomyces sp. LZ35
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Location: 1 - 76,600 nt. (total: 76,600 nt).
This entry is originally from NCBI GenBank JX504844.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000075
Short description hygrocin A biosynthetic gene cluster from Streptomyces sp. LZ35
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
JX504844.1
via
Compounds
  • hygrocin A
  • hygrocin B
Species Streptomyces sp. LZ35 [taxonomy]
References
Chemical products information
hygrocin A Evidence:
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C28H31N1O8
Chemical database entries
NPAtlas
PubCHEM
hygrocin B Evidence:
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C28H29N1O8
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFV30240.1
 1 - 582 (-) TetR family transcriptional regulator
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    • AFV30241.1
    		 762 - 2588 (+) fumarate reductase/succinate dehydrogenase flavoprotein domain protein
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      • AFV30242.1
      		 2612 - 4306 (+) NHL repeat containing protein
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        • AFV30243.1
        		 4327 - 5301 (-) alcohol dehydrogenas
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          • AFV30244.1
          		 5520 - 6149 (+) nitroreductase
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            • AFV30245.1
            • hgc1
            		 6685 - 9609 (+) LuxR family transcriptional regulator
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              • AFV30246.1
              • hgc2
              		 9642 - 11234 (-) FAD-binding monooxygenase
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                • AFV30247.1
                • hgcA
                		 11393 - 27940 (+) polyketide synthase
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                  • AFV30248.1
                  • hgcB
                  		 27967 - 34623 (+) polyketide synthase
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                    • AFV30249.1
                    • hgcC
                    		 34708 - 40260 (+) polyketide synthase
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                      • AFV30250.1
                      • hgcD
                      		 40281 - 46865 (+) polyketide synthase
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                        • AFV30251.1
                        • hgcE
                        		 46865 - 55399 (+) polyketide synthase
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                          • AFV30252.1
                          • hgcF
                          		 55396 - 56280 (+) amide synthase
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                            • AFV30253.1
                            • hgc3
                            		 56293 - 57519 (+) putative FMN-binding monoxygenase
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                              • AFV30254.1
                              • hgc4
                              		 57570 - 58769 (+) cytochrome P450
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                                • AFV30255.1
                                • hgc5
                                		 58770 - 59450 (-) 2OG-Fe(II) oxygenase
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                                  • AFV30256.1
                                  • hgc6
                                  		 59539 - 60267 (-) hypothetical protein
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                                    • AFV30257.1
                                    • hgc7
                                    		 60335 - 60841 (-) putative methylated-DNA-protein-cysteine S-methyltransferase
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                                      • AFV30258.1
                                      • hgc8
                                      		 60954 - 61580 (-) hypothetical protein
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                                        • AFV30259.1
                                        • hgc9
                                        		 61710 - 64433 (-) putative integral membrane sensor protein
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                                          • AFV30260.1
                                          • hgc10
                                          		 64613 - 65563 (+) putative protease B precursor
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                                            • AFV30261.1
                                            • hgc11
                                            		 65868 - 66923 (-) FAD-dependent pyridine nucleotide-disulfide oxidoreductase
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                                              • AFV30262.1
                                              • hgc12
                                              		 67301 - 68119 (+) putative integral-membrane protein
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                                                • AFV30263.1
                                                • hgc13
                                                		 68304 - 68936 (+) putative ECF-family sigma factor
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                                                  • AFV30270.1
                                                  • hgcM
                                                  		 69067 - 69762 (-) phosphatase
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                                                    • AFV30264.1
                                                    • hgcL
                                                    		 69958 - 71046 (-) oxidoreductase
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                                                      • AFV30265.1
                                                      • hgcK
                                                      		 71088 - 72254 (-) AHBA synthase
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                                                        • AFV30266.1
                                                        • hgcJ
                                                        		 72469 - 72915 (+) aDHQ dehydratase
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                                                          • AFV30267.1
                                                          • hgcN
                                                          		 73021 - 73899 (+) kinase
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                                                            • AFV30268.1
                                                            • hgc14
                                                            		 74058 - 74909 (+) MerR family transcriptional regulator
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                                                              • AFV30269.1
                                                              • hgcR1
                                                              		 75063 - 76475 (-) hypothetical protein
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                                                                Biosynthesis information
                                                                Annotation changelog

                                                                Entry version: 4

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-10-07
                                                                Update chemical activity to schema version 2.11
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Updated bioactivity data
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2019-10-16
                                                                Updated compound(s) information (NPAtlas curation)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2015-06-12
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                Detailed domain annotation
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