BGC0000078: incednine biosynthetic gene cluster from Streptomyces sp. ML694-90F3
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Location: 1 - 137,957 nt. (total: 137,957 nt).
This entry is originally from NCBI GenBank AB767280.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000078
Short description incednine biosynthetic gene cluster from Streptomyces sp. ML694-90F3
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AB767280.1
via
Compounds
  • incednine
Species Streptomyces sp. ML694-90F3 [taxonomy]
References
Chemical products information
incednine Evidence:
Copy SMILES
C42H63N3O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAP34699.1
 <5 - 2069 (+) superfamily I DNA and RNA helicase-like protein
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    • BAP34700.1
    		 2126 - 2521 (-) hypothetical protein
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      • BAP34701.1
      		 2644 - 3135 (-) hypothetical protein
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        • BAP34702.1
        • idnA
        		 3362 - 3583 (-) MbtH-like protein
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          • BAP34703.1
          • idnS1
          		 4554 - 5216 (+) LmbE family protein
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            • BAP34704.1
            • idnS2
            		 5408 - 6820 (+) UDP-glucose/GDP-mannose dehydrogenase
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              • BAP34705.1
              • idnS3
              		 6885 - 7841 (+) NAD-dependent epimerase/dehydratase
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                • BAP34706.1
                • idnR1
                		 8085 - 10994 (+) LuxR-family transcriptional regulator
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                  • BAP34707.1
                  • idnL1
                  		 11307 - 12905 (+) AMP-dependent synthetase and ligase
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                    • BAP34708.1
                    • idnL2
                    		 13073 - 14182 (-) malonyl-CoA-ACP transacylase
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                      • BAP34709.1
                      • idnL3
                      		 14197 - 15483 (-) (PLP)-dependent aspartate aminotransferase superfamily
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                        • BAP34710.1
                        • idnL4
                        		 15517 - 16878 (-) radical-SAM L-lysine 2,3-aminomutase
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                          • BAP34711.1
                          • idnL5
                          		 17000 - 17929 (-) proline iminopeptidase
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                            • BAP34712.1
                            • idnS4
                            		 18316 - 19644 (+) glycosyltransferase
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                              • BAP34713.1
                              • idnS5
                              		 19828 - 21036 (-) methyltransferase
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                                • BAP34714.1
                                • idnS6
                                		 21287 - 22261 (-) dTDP-glucose 4,6-dehydratase
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                                  • BAP34715.1
                                  • idnS7
                                  		 22258 - 23325 (-) glucose-1-phosphate thymidylyltransferase
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                                    • BAP34716.1
                                    • idnS8
                                    		 23395 - 24132 (-) N-methyltransferase
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                                      • BAP34717.1
                                      • idnL6
                                      		 24577 - 24816 (-) acyl carrier protein
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                                        • BAP34718.1
                                        • idnL7
                                        		 24954 - 26522 (+) AMP-dependent synthetase and ligase
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                                          • BAP34719.1
                                          • idnO1
                                          		 26677 - 27882 (+) cytochrome P450
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                                            • BAP34720.1
                                            		 28673 - 29308 (+) transcriptional regulator
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                                              • BAP34721.1
                                              		 29779 - 30123 (+) hypothetical protein
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                                                • BAP34722.1
                                                		 30120 - 31583 (+) hypothetical protein
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                                                  • BAP34723.1
                                                  		 31628 - 32032 (+) hypothetical protein
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                                                    • BAP34724.1
                                                    		 32138 - 32599 (+) Putative hydrolase
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                                                      • BAP34725.1
                                                      		 32596 - 32952 (+) hypothetical protein
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                                                        • BAP34726.1
                                                        		 32960 - 33982 (+) thymidylate synthase
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                                                          • BAP34727.1
                                                          		 33979 - 35007 (+) nucleoside diphosphate kinase
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                                                            • BAP34728.1
                                                            		 34997 - 36175 (+) hypothetical protein
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                                                              • BAP34729.1
                                                              		 36172 - 36774 (+) DNA polymerase III
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                                                                • BAP34730.1
                                                                		 36768 - 37376 (+) hypothetical protein
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                                                                  • BAP34731.1
                                                                  		 37373 - 38023 (+) oxidoreductase
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                                                                    • BAP34732.1
                                                                    		 38154 - 38669 (+) hypothetical protein
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                                                                      • BAP34733.1
                                                                      • idnP1
                                                                      		 39077 - 50023 (-) type I polyketide synthase
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                                                                        • BAP34734.1
                                                                        • idnP2
                                                                        		 50108 - 66139 (-) type I polyketide synthase
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                                                                          • BAP34735.1
                                                                          • idnB
                                                                          		 66380 - 67210 (+) thioesterase involved in non-ribosomal peptide biosynthesis
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                                                                            • BAP34736.1
                                                                            • idnT1
                                                                            		 67450 - 68247 (-) ABC-type multidrug transport system
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                                                                              • BAP34737.1
                                                                              • idnT2
                                                                              		 68244 - 69200 (-) ABC-type multidrug transport system
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                                                                                • BAP34738.1
                                                                                • idnR2
                                                                                		 69310 - 70158 (+) regulatory protein TetR
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                                                                                  • BAP34739.1
                                                                                  • idnP3
                                                                                  		 70616 - 82201 (-) type I polyketide synthase
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                                                                                    • BAP34740.1
                                                                                    • idnP4
                                                                                    		 82241 - 87412 (-) type I polyketide synthase
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                                                                                      • BAP34741.1
                                                                                      • idnS9
                                                                                      		 88093 - 89280 (-) glycosyltransferase
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                                                                                        • BAP34742.1
                                                                                        • idnS10
                                                                                        		 89781 - 91136 (+) NDP-hexose 2,3-dehydratase
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                                                                                          • BAP34743.1
                                                                                          • idnS11
                                                                                          		 91214 - 92230 (+) NDP-hexose-3-ketoreductase
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                                                                                            • BAP34744.1
                                                                                            • idnS12
                                                                                            		 92233 - 93567 (+) NDP-hexose-3,4-dehydratase
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                                                                                              • BAP34745.1
                                                                                              • idnS13
                                                                                              		 93557 - 94852 (+) aminotransferase
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                                                                                                • BAP34746.1
                                                                                                • idnS14
                                                                                                		 94907 - 96184 (-) glycosyltransferase
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                                                                                                  • BAP34747.1
                                                                                                  • idnO2
                                                                                                  		 96199 - 97470 (-) cytochrome P450
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                                                                                                    • BAP34748.1
                                                                                                    • idnS15
                                                                                                    		 97467 - 98396 (-) glycosyltransferase
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                                                                                                      • BAP34749.1
                                                                                                      		 100768 - 102102 (-) glutamate-1-semialdehyde aminotransferase
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                                                                                                        • BAP34750.1
                                                                                                        		 102204 - 102950 (+) dehydrogenase
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                                                                                                          • BAP34751.1
                                                                                                          		 102813 - 103463 (-) hypothetical protein
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                                                                                                            • BAP34752.1
                                                                                                            		 103460 - 104269 (-) phytanoyl-CoA dioxygenase
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                                                                                                              • BAP34753.1
                                                                                                              		 106414 - 107517 (-) hypothetical protein
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                                                                                                                • BAP34754.1
                                                                                                                		 107471 - 108973 (-) hypothetical protein
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                                                                                                                  • BAP34755.1
                                                                                                                  		 109004 - 109738 (+) hypothetical protein
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                                                                                                                    • BAP34756.1
                                                                                                                    		 109890 - 110147 (-) hypothetical protein
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                                                                                                                      • BAP34757.1
                                                                                                                      		 112262 - 112504 (-) hypothetical protein
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                                                                                                                        • BAP34758.1
                                                                                                                        		 112454 - 112819 (+) hypothetical protein
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                                                                                                                          • BAP34759.1
                                                                                                                          		 113029 - 113415 (+) hypothetical protein
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                                                                                                                            • BAP34760.1
                                                                                                                            		 113419 - 114375 (+) hypothetical protein
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                                                                                                                              • BAP34761.1
                                                                                                                              		 114372 - 115568 (+) O-methyltransferase
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                                                                                                                                • BAP34762.1
                                                                                                                                		 116103 - 116555 (-) secreted protein
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                                                                                                                                  • BAP34763.1
                                                                                                                                  • idnP5
                                                                                                                                  		 116795 - 128485 (-) type I polyketide synthase
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                                                                                                                                    • BAP34764.1
                                                                                                                                    • idnM1
                                                                                                                                    		 129343 - 130209 (+) glyceryl-ACP oxidoreductase
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                                                                                                                                      • BAP34765.1
                                                                                                                                      • idnM2
                                                                                                                                      		 130206 - 130502 (+) acyl carrier protein
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                                                                                                                                        • BAP34766.1
                                                                                                                                        • idnM3
                                                                                                                                        		 130495 - 131727 (+) acyl-CoA dehydrogenase
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                                                                                                                                          • BAP34767.1
                                                                                                                                          • idnM4
                                                                                                                                          		 131744 - 132865 (+) FkbH-like protein
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                                                                                                                                            • BAP34768.1
                                                                                                                                            • idnM5
                                                                                                                                            		 133147 - 133809 (-) O-methyltransferase
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                                                                                                                                              • BAP34769.1
                                                                                                                                              		 134104 - 134511 (+) hypothetical protein
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                                                                                                                                                • BAP34770.1
                                                                                                                                                		 134598 - 136205 (-) spermidine synthase
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                                                                                                                                                  • BAP34771.1
                                                                                                                                                  		 136213 - 136650 (-) hypothetical protein
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                                                                                                                                                    • BAP34772.1
                                                                                                                                                    		 136709 - 137125 (-) hypothetical protein
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                                                                                                                                                      • BAP34773.1
                                                                                                                                                      		 137122 - 137706 (-) hypothetical protein
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                                                                                                                                                        Biosynthesis information

                                                                                                                                                        No biosynthesis information available for this record.

                                                                                                                                                        Annotation changelog

                                                                                                                                                        Entry version: 5

                                                                                                                                                        Date
                                                                                                                                                        Changes
                                                                                                                                                        Submitters
                                                                                                                                                        Reviewers
                                                                                                                                                        2024-03-19
                                                                                                                                                        MIBiG v4 annotathon
                                                                                                                                                        • (ID: A7MF26CMS75H6APVYNE75JID)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                        Entry version: 4

                                                                                                                                                        Date
                                                                                                                                                        Changes
                                                                                                                                                        Submitters
                                                                                                                                                        Reviewers
                                                                                                                                                        2022-10-07
                                                                                                                                                        Update chemical activity to schema version 2.11
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                        Entry version: 3

                                                                                                                                                        Date
                                                                                                                                                        Changes
                                                                                                                                                        Submitters
                                                                                                                                                        Reviewers
                                                                                                                                                        2022-09-15
                                                                                                                                                        Updated bioactivity data
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                        Entry version: 2

                                                                                                                                                        Date
                                                                                                                                                        Changes
                                                                                                                                                        Submitters
                                                                                                                                                        Reviewers
                                                                                                                                                        2019-10-16
                                                                                                                                                        Migrated from v1.4
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        2019-10-16
                                                                                                                                                        Updated compound(s) information (NPAtlas curation)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                                        Entry version: 1

                                                                                                                                                        Date
                                                                                                                                                        Changes
                                                                                                                                                        Submitters
                                                                                                                                                        Reviewers
                                                                                                                                                        2015-06-12
                                                                                                                                                        Submitted
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                                                                                        Detailed domain annotation
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