BGC0000079: X-14547 biosynthetic gene cluster from Streptomyces antibioticus
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Location: 1 - 79,604 nt. (total: 79,604 nt).
This entry is originally from NCBI GenBank FJ545274.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000079
Short description X-14547 biosynthetic gene cluster from Streptomyces antibioticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
FJ545274.1
via Knock-out studies
Compounds
  • X-14547
Species Streptomyces antibioticus [taxonomy]
References
Chemical products information
X-14547 Evidence:
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C31H43N1O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN69973.1
 190 - 954 (+) metallo beta lactamase family protein
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    • ACN69974.1
    		 1616 - 1861 (+) hypothetical protein
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      • ACN69975.1
      		 1951 - 3240 (-) putative penicillin binding protein
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        • ACN69976.1
        		 3383 - 4144 (+) hypothetical protein
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          • ACN69977.1
          • idmA
          		 4402 - 5160 (+) type II thioesterase
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            • ACN69978.1
            • idmB
            		 5170 - 6759 (+) acyl-CoA carboxylase
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              • ACN69979.1
              • idmC
              		 6894 - 8444 (-) efflux transporter
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                • ACN69980.1
                • idmD
                		 8437 - 9033 (-) MarR regulatory protein
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                  • ACN69981.1
                  • idmE
                  		 9131 - 10840 (-) hydroxybutyryl-CoA dehydrogenase
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                    • ACN69982.1
                    • idmF
                    		 10837 - 12213 (-) crotonyl-CoA reductase/carboxylase
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                      • ACN69983.1
                      • idmG
                      		 13164 - 15890 (+) LuxR family transcriptional regulator
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                        • ACN69984.1
                        • idmH
                        		 16017 - 16454 (-) hypothetical protein
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                          • ACN69985.1
                          • idmI
                          		 16756 - 17889 (+) prolyl carrier protein dehydrogenase
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                            • ACN69986.1
                            • idmJ
                            		 17886 - 19376 (+) proline adenyltransferase
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                              • ACN69987.1
                              • idmK
                              		 19428 - 19703 (+) proline carrier protein
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                                • ACN69988.1
                                • idmL
                                		 19774 - 34113 (+) polyketide synthase
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                                  • ACN69989.1
                                  • idmM
                                  		 34110 - 44900 (+) polyketide synthase
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                                    • ACN69990.1
                                    • idmN
                                    		 44903 - 60547 (+) polyketide synthase
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                                      • ACN69991.1
                                      • idmO
                                      		 60601 - 67128 (+) polyketide synthase
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                                        • ACN69992.1
                                        • idmP
                                        		 67125 - 74768 (+) polyketide synthase
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                                          • ACN69993.1
                                          		 75583 - 77058 (+) hypothetical protein
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                                            • ACN69994.1
                                            		 77084 - 77524 (-) hypothetical protein
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                                              • ACN69995.1
                                              		 79100 - 79501 (+) putative replication initiation protein
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                                                Biosynthesis information

                                                No biosynthesis information available for this record.

                                                Annotation changelog

                                                Entry version: 4

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Update chemical activity to schema version 2.11
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 3

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Updated bioactivity data
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Added AMP-binding domain substrate specificities
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Migrated from v1.4
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (MIBiG Annotathon)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2019-10-16
                                                Updated compound(s) information (NPAtlas curation)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2015-06-12
                                                Submitted
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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