BGC0000080 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000080 (Sorangium cellulosum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	67,323	jerangolid A/jerangolid D	PKS	100%

BGC0000080 - Region 1 - T1PKS

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Location: 1 - 67,323 nt. (total: 67,323 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 67,324
Label		BGC0000080

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000080	1.00	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000122	0.33	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.31	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.31	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001163	0.30	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000067	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164	0.29	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000050	0.29	Polyketide	E-837	Streptomyces aculeolatus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000080	1.00	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000122	0.67	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0000041	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001163	0.63	Polyketide	1-heptadecene	Moorea producens 3L
BGC0000067	0.63	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000050	0.62	Polyketide	E-837	Streptomyces aculeolatus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 67323:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal) + (Me-ohmal - redmal) + (Me-ccmal - ccmal) + (ccmal) + (ohmal - pk)
Non-colinear ordering:: jerA + jerB + jerC + jerD + jerE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

jerA

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.2
Ethylmalonyl-CoA: 180.8
Methoxymalonyl-CoA: 156.6
2-Methylbutyryl-CoA: 121.9
Isobutyryl-CoA: 105.4
Malonyl-CoA: 101.2
Propionyl-CoA: 100.2
trans-1,2-CPDA: 87.4
CHC-CoA: 78.1
Benzoyl-CoA: 58.3
fatty_acid: 54.5
Acetyl-CoA: 51.5
3-Methylbutyryl-CoA: 25.9
inactive: 19.6

jerB

PKS_AT (564..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.9
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 161.2
2-Methylbutyryl-CoA: 129.6
Malonyl-CoA: 106.5
Propionyl-CoA: 99.1
trans-1,2-CPDA: 97.5
Isobutyryl-CoA: 96.5
CHC-CoA: 86.0
Acetyl-CoA: 62.9
Benzoyl-CoA: 57.4
fatty_acid: 49.0
3-Methylbutyryl-CoA: 33.1
inactive: 30.3

PKS_AT (2048..2349): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.8
inactive: 104.0
Methoxymalonyl-CoA: 67.7
Methylmalonyl-CoA: 61.1
Propionyl-CoA: 42.8
Isobutyryl-CoA: 37.4
2-Methylbutyryl-CoA: 33.5
Benzoyl-CoA: 27.9
Acetyl-CoA: 24.7
Ethylmalonyl-CoA: 23.3
trans-1,2-CPDA: 16.3
fatty_acid: 10.6
CHC-CoA: 9.2
3-Methylbutyryl-CoA: 8.5

jerC

PKS_AT (571..868): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.4
Ethylmalonyl-CoA: 196.5
Methoxymalonyl-CoA: 169.2
2-Methylbutyryl-CoA: 132.7
Isobutyryl-CoA: 113.6
Malonyl-CoA: 110.5
Propionyl-CoA: 109.9
trans-1,2-CPDA: 98.0
CHC-CoA: 92.8
Benzoyl-CoA: 69.0
Acetyl-CoA: 65.7
fatty_acid: 46.0
3-Methylbutyryl-CoA: 35.6
inactive: 30.9

PKS_AT (2352..2653): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.4
inactive: 104.8
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 60.7
Propionyl-CoA: 41.7
Isobutyryl-CoA: 36.3
2-Methylbutyryl-CoA: 31.5
Benzoyl-CoA: 26.8
Acetyl-CoA: 24.7
Ethylmalonyl-CoA: 22.1
trans-1,2-CPDA: 15.4
fatty_acid: 9.9
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 7.9

jerD

PKS_AT (571..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.8
inactive: 130.6
Methoxymalonyl-CoA: 72.4
Methylmalonyl-CoA: 60.6
Propionyl-CoA: 33.4
Isobutyryl-CoA: 29.7
Ethylmalonyl-CoA: 27.9
Acetyl-CoA: 24.6
2-Methylbutyryl-CoA: 24.3
Benzoyl-CoA: 23.0
trans-1,2-CPDA: 14.5
CHC-CoA: 10.8
fatty_acid: 6.5
3-Methylbutyryl-CoA: 0.0

jerE

PKS_AT (574..875): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.6
inactive: 128.4
Methoxymalonyl-CoA: 69.8
Methylmalonyl-CoA: 58.8
Propionyl-CoA: 35.6
Isobutyryl-CoA: 28.4
Ethylmalonyl-CoA: 26.5
2-Methylbutyryl-CoA: 25.8
Acetyl-CoA: 23.4
Benzoyl-CoA: 21.8
CHC-CoA: 14.8
trans-1,2-CPDA: 13.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2131..2428): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.6
Methylmalonyl-CoA: 217.3
Methoxymalonyl-CoA: 187.3
trans-1,2-CPDA: 144.6
2-Methylbutyryl-CoA: 144.4
CHC-CoA: 109.5
Propionyl-CoA: 108.6
Malonyl-CoA: 101.4
Isobutyryl-CoA: 92.9
Benzoyl-CoA: 74.3
Acetyl-CoA: 64.1
fatty_acid: 45.4
3-Methylbutyryl-CoA: 38.5
inactive: 33.1